全文获取类型
收费全文 | 497篇 |
免费 | 17篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 7篇 |
妇产科学 | 4篇 |
基础医学 | 42篇 |
口腔科学 | 2篇 |
临床医学 | 80篇 |
内科学 | 106篇 |
神经病学 | 94篇 |
特种医学 | 21篇 |
外科学 | 102篇 |
综合类 | 3篇 |
预防医学 | 33篇 |
药学 | 18篇 |
肿瘤学 | 13篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 11篇 |
2021年 | 23篇 |
2020年 | 7篇 |
2019年 | 8篇 |
2018年 | 20篇 |
2017年 | 12篇 |
2016年 | 16篇 |
2015年 | 13篇 |
2014年 | 24篇 |
2013年 | 24篇 |
2012年 | 39篇 |
2011年 | 43篇 |
2010年 | 22篇 |
2009年 | 29篇 |
2008年 | 30篇 |
2007年 | 37篇 |
2006年 | 37篇 |
2005年 | 14篇 |
2004年 | 19篇 |
2003年 | 20篇 |
2002年 | 25篇 |
2001年 | 5篇 |
2000年 | 6篇 |
1999年 | 8篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1971年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有526条查询结果,搜索用时 0 毫秒
101.
102.
103.
Myrella Vlenterie Melissa H.S. Hillebrandt-Roeffen Uta E. Flucke Patricia J.T.A. Groenen Bastiaan B.J. Tops Eveline J. Kamping Rolph Pfundt Diederik R.H. de Bruijn Ad H.M. Geurts van Kessel Han J.H.J.M. van Krieken Winette T.A. van der Graaf Yvonne M.H. Versleijen-Jonkers 《Oncotarget》2015,6(33):34680-34690
Over 95% of all synovial sarcomas (SS) share a unique translocation, t(X;18), however, they show heterogeneous clinical behavior. We analyzed multiple SS to reveal additional genetic alterations besides the translocation. Twenty-six SS from 22 patients were sequenced for 409 cancer-related genes using the Comprehensive Cancer Panel (Life Technologies, USA) on an Ion Torrent platform. The detected variants were verified by Sanger sequencing and compared to matched normal DNAs. Copy number variation was assessed in six tumors using the Oncoscan array (Affymetrix, USA). In total, eight somatic mutations were detected in eight samples. These mutations have not been reported previously in SS. Two of these, in KRAS and CCND1, represent known oncogenic mutations in other malignancies. Additional mutations were detected in RNF213, SEPT9, KDR, CSMD3, MLH1 and ERBB4. DNA alterations occurred more often in adult tumors. A distinctive loss of 6q was found in a metastatic lesion progressing under pazopanib, but not in the responding lesion. Our results emphasize t(X;18) as a single initiating event in SS and as the main oncogenic driver. Our results also show the occurrence of additional genetic events, mutations or chromosomal aberrations, occurring more frequently in SS with an onset in adults. 相似文献
104.
Unraveling Patient‐Preferred Health and Treatment Outcomes in Early Rheumatoid Arthritis: A Longitudinal Qualitative Study
下载免费PDF全文
![点击此处可从《Arthritis care & research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
105.
106.
107.
Scohy TV Lecomte PV McGhie J Meijer R Gommers D Hofland J Ten Cate FJ 《Echocardiography (Mount Kisco, N.Y.)》2008,25(6):646-649
Right atrial myxomas are uncommon heart tumors that can simulate nonspecific symptoms, such as fever, paroxysmal palpitations, chronic anemia, weight loss, and may escape timely diagnosis until the development of severe complications due to embolism. We present a patient with a history of palpitations. In search for the source of palpitations, a 2D transthoracic echocardiography was performed, showing a right atrial mass. Real time three-dimensional transesophageal echocardiography (RT3DTEE) was performed intraoperative and demonstrated very accurate information about the size and the morphology of the tumor. This is the first case report of a right atrial myxoma visualized intraoperatively by RT3DTEE . 相似文献
108.
G. F. Vazquez de Anda A. Hartog S. J. C. Verbrugge D. Gommers B. Lachmann 《Intensive care medicine》1999,25(9):990-996
Objective: To demonstrate in experimental animals with respiratory insufficiency that under well-defined conditions, commercially available
ventilators allow settings which are as effective as high frequency oscillatory ventilators (HFOV), with respect to the levels
of gas exchange, protein infiltration, and lung stability. Design: Prospective, randomized, animal study. Setting: Experimental laboratory of a university. Subjects: 18 adult male Sprague-Dawley rats. Interventions: Lung injury was induced by repeated whole-lung lavage. Thereafter, the animals were assigned to pressure-controlled ventilation
(PCV) plus The Open Lung Concept (OLC) or HFOV plus OLC (HFOOLC). In both groups, an opening maneuver was performed by increasing airway pressures to improve the arterial oxygen tension/fractional
inspired oxygen (PaO2/FIO2) ratio to L 500 mm Hg; thereafter, airway pressures were reduced to minimal values, which kept PaO2/FIO2 L 500 mm Hg. Pressure amplitude was adjusted to keep CO2 as close as possible in the normal range. Measurements and results: Airway pressure, blood gas tension, and arterial blood pressure were recorded every 30 min. At the end of the 3-h study period,
a pressure-volume curve was recorded and bronchoalveolar lavage was performed to determine protein content. After the recruitment
maneuver, the resulting mean airway pressure to keep a PaO2/FIO2 L 500 mm Hg was 25 ± 1.3 cm H2O during PCVOLC and 25 ± 0.5 cm H2O during HFOVOLC. Arterial oxygenation in both groups was above L 500 mm Hg and arterial carbon dioxide tension was kept close to the normal
range. No differences in mean arterial pressure, lung mechanics and protein influx were found between the two groups. Conclusions: This study shows that in surfactant-deficient animals, PCV, in combination with a recruitment maneuver, opens atelectatic
lung areas and keeps them open as effectively as HFOV.
Received: 14 October 1998 Final revision received: 11 April 1999 Accepted: 25 June 1999 相似文献
109.
110.
El Hachioui H van de Sandt-Koenderman MW Dippel DW Koudstaal PJ Visch-Brink EG 《International journal of rehabilitation research. Internationale Zeitschrift für Rehabilitationsforschung. Revue internationale de recherches de réadaptation》2011,34(3):215-221
Aphasia recovery after stroke has been the subject of several studies, but in none the deficits on the various linguistic levels were examined, even though in the diagnosis and treatment of aphasia the emphasis lays more and more on these linguistic level disorders. In this observational prospective follow-up study, we explored whether it is meaningful to investigate the recovery of semantics, phonology, and syntax separately. Fifteen patients with aphasia poststroke were assessed at 3 and 10 days, 7 weeks, 4 and 7 months, and 3 years postonset with the ScreeLing, a linguistic level test, the Aphasia Severity Rating Scale (spontaneous speech) and the Token Test. Group results showed improvement for the overall ScreeLing (P<0.01) and its subparts semantics (P<0.01) and syntax (P<0.01) up to 7 weeks, just as the Token Test (P<0.01). Phonology improved up to 4 months (P<0.05) and spontaneous speech up to 7 months (P<0.05). The recovery pattern of the three linguistic levels did not follow a parallel course, with a great deal of variability in linguistic recovery curves between and within patients. These results suggest that it is meaningful to assess the recovery of the linguistic levels separately, starting from the acute stage poststroke. 相似文献