全文获取类型
收费全文 | 62669篇 |
免费 | 3369篇 |
国内免费 | 196篇 |
专业分类
耳鼻咽喉 | 852篇 |
儿科学 | 4368篇 |
妇产科学 | 1244篇 |
基础医学 | 7441篇 |
口腔科学 | 1501篇 |
临床医学 | 4098篇 |
内科学 | 11475篇 |
皮肤病学 | 1978篇 |
神经病学 | 3352篇 |
特种医学 | 1996篇 |
外科学 | 9332篇 |
综合类 | 2095篇 |
一般理论 | 26篇 |
预防医学 | 3172篇 |
眼科学 | 2612篇 |
药学 | 5895篇 |
1篇 | |
中国医学 | 458篇 |
肿瘤学 | 4338篇 |
出版年
2023年 | 380篇 |
2022年 | 1168篇 |
2021年 | 2213篇 |
2020年 | 1217篇 |
2019年 | 1388篇 |
2018年 | 1951篇 |
2017年 | 1379篇 |
2016年 | 1854篇 |
2015年 | 1838篇 |
2014年 | 2694篇 |
2013年 | 3133篇 |
2012年 | 4454篇 |
2011年 | 4439篇 |
2010年 | 2577篇 |
2009年 | 2059篇 |
2008年 | 3106篇 |
2007年 | 3216篇 |
2006年 | 2888篇 |
2005年 | 2628篇 |
2004年 | 2444篇 |
2003年 | 2147篇 |
2002年 | 1863篇 |
2001年 | 1464篇 |
2000年 | 1335篇 |
1999年 | 1156篇 |
1998年 | 506篇 |
1997年 | 383篇 |
1996年 | 348篇 |
1995年 | 317篇 |
1994年 | 265篇 |
1993年 | 253篇 |
1992年 | 690篇 |
1991年 | 708篇 |
1990年 | 688篇 |
1989年 | 671篇 |
1988年 | 579篇 |
1987年 | 512篇 |
1986年 | 492篇 |
1985年 | 498篇 |
1984年 | 383篇 |
1983年 | 297篇 |
1979年 | 343篇 |
1978年 | 225篇 |
1977年 | 231篇 |
1976年 | 198篇 |
1975年 | 217篇 |
1974年 | 204篇 |
1973年 | 234篇 |
1972年 | 184篇 |
1971年 | 180篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
63.
Use of fMRI to predict psychiatric adverse effects of interferon treatment for Hepatitis C – preliminary report
下载免费PDF全文
![点击此处可从《Neuropsychiatric Disease and Treatment》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Donald H Marks Mehdi Adineh Binquan Wang Sudeepa Gupta 《Neuropsychiatric Disease and Treatment》2007,3(5):655-667
Interferon alfa2 (IFN-α2) is a parenterally administered cytokine used to treat patients with Hepatitis C and B, and malignancy. Interferon (INF) has a relatively high rate of central nervous system (CNS) adverse effects, including agitation, depression, fatigue, cognitive dysfunction, suicidal thought and drug craving. Using functional magnetic resonance imaging (fMRI) we studied patients with Hepatitis C virus (HCV) infection who were not more than mildly clinically depressed at baseline for their CNS reaction to IFN-α2. During fMRI, patients underwent visual stimulation with pictures designed to induce feelings of depression. In the two patients who became clinically depressed or markedly anxious while on treatment with interferon, but not in patients who did not experience these effects, there was a significant activation in specific areas of the brain known to be involved with depression, along with an increase above baseline in the Beck Depression Scale for the patient who developed INF-induced depression. The activation pattern differed from that previously observed for endogenous depression, indicating that INF-induced depression may differ in its underlying neuropathology. Functional magnetic resonance imaging can be an important tool in understanding and monitoring for (INF and other) medication-induced CNS effects, and response to treatment. 相似文献
64.
Sandeep Mahajan Suresh C Tiwari Vikram Kalra Dipankar M Bhowmik Sanjay K Agarwal Suresh C Dash Parveen Kumar 《Peritoneal dialysis international》2005,25(5):473-477
BACKGROUND: Staphylococcus aureus-associated peritonitis and catheter exit-site infections (ESIs) are important causes of hospitalization and catheter loss in patients undergoing chronic peritoneal dialysis. Intranasal and topical use of mupirocin has been found to be an effective strategy in decreasing S. aureus-related infectious complications in persons who are carriers of S. aureus; however, there is no consensus regarding the prophylactic use of mupirocin irrespective of carrier status. We aimed to determine the potential effectiveness of application of mupirocin cream at the catheter exit site in preventing ESI and peritonitis irrespective of carrier status in a tropical country such as India. METHODS: This prospective historically controlled study was done in a total of 40 patients. From August 2003, all patients, incident and prevalent, were instructed to apply 2% mupirocin cream daily to the exit site instead of the older practice of povidone-iodine and gauze dressing. Patients were not screened to determine whether they were S. aureus carriers. The infection-related data for 1 year, until July 2004, were compared with the historical control, which was infection-related data for the year preceding the year of mupirocin application. RESULTS: Mean age of the study population was 62 years, with 61.8% being male and 64.3% being diabetic. Local application of mupirocin led to a significant reduction in the incidence density per patient-month of both ESI and peritonitis compared to controls (0.15 vs 0.37 and 0.37 vs 0.67, p = 0.01 for both). This amounted to a relative reduction of 60.5% and 55% respectively. ESI and peritonitis due to S. aureus were also significantly lower in the study group compared to controls (incidence density per patient-month 0.05 vs 0.13 and zero vs 0.17 respectively, p < 0.01 for both). There occurred no catheter removal due to infection-related complications during the study period compared to two during the control period. None of the patients reported a mupirocin-related adverse effect. CONCLUSIONS: Daily application of mupirocin at the exit site is a well-tolerated and effective strategy in reducing the incidence of ESI and peritonitis in a tropical country such as India. It can thus significantly reduce morbidity, catheter loss, and transfer to hemodialysis in peritoneal dialysis patients. 相似文献
65.
66.
Since the first transurethral resection of the prostate (TURP) was performed by Guyon at the Necker Hospital in Paris in 1901,
this treatment modality has replaced open prostatectomy as the procedure of choice for more than 95% of patients. TURP has
been used in surgical treatment of benign prostatic hyperplasia (BPH) and remains the gold standard treatment. Transurethral
vapor resection of the prostate (TUVRP) and holmium laser enucleation of the prostate (HoLEP) are new treatment modalities
for the treatment of BPH. Each procedure has its own advantages and disadvantages. Availability of instruments, surgical expertise,
and specific indications for a particular procedure are of utmost importance for successful outcome, with minimal morbidity.
TURP can be either monopolar or bipolar, using thin or thick loop. Bipolar TURP is associated with less bleeding and less
chances of dilutional hyponatremia. TUVRP, using a thick wedge loop, causes vaporization and resection of the prostate, and
is associated with less bleeding and short operative time. HoLEP is another effective alternative for the surgical treatment
of BPH. The holmium laser possesses the ideal combination of cutting and coagulation; however, it has a learning curve. 相似文献
67.
Samir Kumar Praharaj mbbs md dpm Nishant Goyal mbbs md dpm Sukanto Sarkar mbbs md dpm Dhruv Bagati mbbs Prakriti Sinha mp hil Vinod Kumar Sinha mbbs md dpm 《Psychiatry and clinical neurosciences》2009,63(2):230-234
Reported herein is a case of obsessive–compulsive disorder with persistent and distressing musical obsessions along with other symptoms. Advanced source analysis of electroencephalographic data indicated high spectral power over the bifrontal region. The musical symptoms were resistant to pharmacotherapy but there was some reduction in frequency and duration of musical obsessions with thought-stopping technique. 相似文献
68.
Nand L. Sharma Vikram K. Mahajan Neelam Gupta Nitin Ranjan and Anju Lath 《Journal of cutaneous pathology》2009,36(4):486-492
Ehlers-Danlos syndrome – vascular type, the only lethal form, is rarely reported in dermatology literature. It is characterized by translucent, atrophic skin, easy bruising, arterial, intestinal and/or uterine fragility manifesting as varicose veins, aneurysms and vascular/visceral/uterine rupture. As its dermatopathologic features are not well elucidated, diagnosis is often made after a catastrophic complication or at autopsy. This 36 year-old non-consanguineous male had brown-black plaques with atrophy and frequent ulceration over legs and dorsal feet and tortuous varicose veins around ankles for the past 15 years. Perivenous skin was translucent and hypopigmented. He had multiple and ecchymotic keloids and small atrophic, pityriasis versicolor-like lesions over trunk. He did not have hypermobile/hyperextensible skin and joints and showed no systemic or investigative abnormality. Histopathologic features of atrophic lesion included blood extravasation in atrophic epidermis/dermis, focal clustering and dilatation of blood vessels, malformed vessel walls, abundant hemosiderin in the dermis and homogenously stained/whorled patterned collagen especially around blood vessels. Pathology of keloidal lesion showed new collagen and vascular fragility. These histopathologic features appear of diagnostic value especially in patients who have compatible clinical findings but cannot afford confirmation by biochemical testing for abnormal synthesis of type III procollagen or identification of mutations in the COL3A1 gene. 相似文献
69.
70.
A case of odontoameloblastoma affecting the left mandible is reported. Initially treated by conservative excision due to its small size, the lesion recurred after 18 months and was treated by radical excision and subsequent reconstruction by a rib graft. 相似文献