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41.
Ricky K. Taira PhD David B. Johnson Vikas Bhushan Monica Rivera Clement Wong Lujia Huang Denise R. Aberle Melanie Greaves Jonathan G. Goldin 《Journal of digital imaging》1996,9(1):25-36
Current digital information systems in radiology are insufficient to accommodate the retrieval needs of academicians. Significant efforts are required in retrieving clinical cases for teaching and research. We describe a prototype system that supports intelligent case retrieval based on a combined specification of patient demographics, radiologic findings, and pathologic diagnoses. The documents for these cases can be distributed among multiple heterogeneous data bases. The system features automatic indexing of radiology and pathology reports, a comprehensive lexicon for thoracic radiology, an interface to a hospital information system, radiology information system, and picture archiving and communication systems, and a graphical user interface for query formulation and results visualization. The prototype system was developed within the domain of thoracic radiology involving patients with lung cancer. 相似文献
42.
Predictors of low CD4 count in resource-limited settings: based on an antiretroviral-naive heterosexual thai population 总被引:1,自引:0,他引:1
Costello C Nelson KE Jamieson DJ Spacek L Sennun S Tovanabutra S Rungruengthanakit K Suriyanon V Duerr A 《Journal of acquired immune deficiency syndromes (1999)》2005,39(2):242-248
A barrier to the appropriate provision of antiretroviral therapy to treat immunosuppressed HIV-infected persons in resource-poor countries is identifying who requires treatment. The World Health Organization (WHO) has suggested using a clinical algorithm combined with a total lymphocyte count (TLC) < 1200 cells/mm as a surrogate for a CD4 count less than 200 cells/mm when it is not possible to measure the CD4 count. We evaluated various TLC levels, anemia, and body mass index and compared our data with the WHO criteria to develop a more sensitive algorithm to predict CD4 counts of < 200 cells/mm and < 350 cells/mm in 839 men and women from Thailand infected with HIV-1 subtype E (CRF01_AE). The December 2003 WHO guidelines had a sensitivity of 34.1% in men and 31.8% in women to detect persons with a CD4 count < 200 cells/mm in this HIV-infected population from Thailand. The use of a TLC < 1500 cells/mm or TLC < 2000 cells/mm combined with anemia or WHO stage II infection doubled the sensitivity to detect persons with a CD4 count < 200 (63.0% in men, 68.2% in women) with less than a 6% decrease in specificity. 相似文献
43.
Fadare O Hileeto D Gruddin YL Mariappan MR 《Archives of pathology & laboratory medicine》2004,128(9):1046-1049
Although mucoepidermoid carcinoma is the most common primary malignancy of the salivary glands, the sclerosing morphologic variant of this tumor is extremely rare, with only 6 reported cases. As its name suggests, sclerosing mucoepidermoid carcinoma is characterized by an intense central sclerosis that occupies the entirety of an otherwise typical tumor, frequently with an inflammatory infiltrate of plasma cells, eosinophils, and/or lymphocytes at its peripheral regions. The sclerosis associated with these tumors may obscure their typical morphologic features and result in diagnostic difficulties. Tumor infarction and extravasation of mucin eventuating in reactive fibrosis are 2 mechanisms of formation that have been suggested as underlying this morphologic variant. We describe herein another case of sclerosing mucoepidermoid carcinoma that was diagnosed in a 44-year-old woman and review the relevant literature. Morphologic evidence in support of the mucin extravasation hypothesis was identified, as small pools of mucin were present throughout the tumor. However, there was no concentration of the mucin pools near the areas with the most viable tumor cells, which would have provided evidence for a temporal sequence that eventuates in lack of mucin in the most sclerotic regions. 相似文献
44.
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination 下载免费PDF全文
Wong SJ Boyle RH Demarest VL Woodmansee AN Kramer LD Li H Drebot M Koski RA Fikrig E Martin DA Shi PY 《Journal of clinical microbiology》2003,41(9):4217-4223
West Nile virus (WNV) is an emerging flavivirus that has caused frequent epidemics since 1996. Besides natural transmission by mosquitoes, WNV can also be transmitted through blood transfusion and organ transplantation, thus heightening the urgency of development of a specific and rapid serologic assay of WNV infection. The current immunoassays lack specificity because they are based on detection of antibodies against WNV structural proteins and immune responses to structural proteins among flaviviruses cross-react to each other. Here, we describe microsphere immunoassays that detect antibodies to nonstructural proteins 3 and 5 (NS3 and NS5). In contrast to immunoassays based on viral envelope and NS3 proteins, the NS5-based assay (i) reliably discriminates between WNV infections and dengue virus or St. Louis encephalitis virus infections, (ii) differentiates between flavivirus vaccination and natural WNV infection, and (iii) indicates recent infections. These unique features of the NS5-based immunoassay will be very useful for both clinical and veterinary diagnosis of WNV infection. 相似文献
45.
46.
Supernatants obtained from non-stimulated lymphocytes, lymphocytes stimulated with phytohaemagglutinin and lymphocytes from patients with schistosomiasis that were stimulated with Schistosomiasis haematobium ova were shown to enhance a number of eosinophil functions. Eosinophil chemotaxis, phagocytosis, microbicidal activity, Nitro blue tetrazolium reduction, hexose monophosphate shunt activity and glycolysis were increased. Eosinophil iodination was not affected. Only those supernatants obtained from phytohaemagglutinin stimulated lymphocytes and lymphocytes from patients with schistosomiasis that were stimulated with S. haematobium ova showed eosinophil chemotactic activity. The active factor was found to be heat stable, and had no effect on cAMP and cGMP metabolism. The most likely mechanism of enhanced eosinophil function is through the increased activity of the hexose monophosphate shunt activity and glycolysis. 相似文献
47.
Carol A Mathews Caroline M Nievergelt Amin Azzam Helena Garrido Denise A Chavira Jennifer Wessel Monica Bagnarello Victor I Reus Nicholas J Schork 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2007,(2):174-182
To date, only one complete genome screen for obsessive-compulsive disorder (OCD) has been published. That study identified a region of suggestive linkage (maximum lod score of 2.25) with a relatively small sample size (N = 56; 27 with OCD). Additional complete genome screens are needed to confirm this finding and identify other regions of linkage. We present the clinical characteristics and power to detect linkage of 11 multigenerational families with OCD and hoarding (N = 92; 44 with OCD), as well as heritability estimates for several quantitative traits. Families with at least two individuals with OCD were identified through probands with childhood-onset OCD. Expected lod scores were calculated for simulated genetic marker data under an additive and two dominant models assuming a dense SNP marker map. All affected individuals had an early age of onset (18 or younger). Hoarding was present in 46% of subjects. Obsessive-compulsive symptoms and hoarding were highly heritable. The maximum mean expected lod score was 3.31 for OCD and 1.39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding. 相似文献
48.
Rocha-Rodrigues DB Paschoini G Pereira SA dos Reis MA Teixeira Vde P Rodrigues Júnior V 《Clinical and diagnostic laboratory immunology》2003,10(5):741-743
Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response. 相似文献
49.
Paul?D.?WatersEmail author Margaret?L.?Delbridge Janine?E.?Deakin Nisrine?El-Mogharbel Patrick?J.?Kirby Denise?R.?Carvalho-Silva Jennifer?A.?Marshall?Graves 《Chromosome research》2005,13(4):401-410
Mammalian sex chromosomes evolved from an ancient autosomal pair. Mapping of human X- and Y-borne genes in distantly related mammals and non-mammalian vertebrates has proved valuable to help deduce the evolution of this unique part of the genome. The platypus, a monotreme mammal distantly related to eutherians and marsupials, has an extraordinary sex chromosome system comprising five X and five Y chromosomes that form a translocation chain at male meiosis. The largest X chromosome (X1), which lies at one end of the chain, has considerable homology to the human X. Using comparative mapping and the emerging chicken database, we demonstrate that part of the therian X chromosome, previously thought to be conserved across all mammals, was lost from the platypus X1 to an autosome. This region included genes flanking the XIST locus, and also genes with Y-linked homologues that are important to male reproduction in therians. Since these genes lie on the X in marsupials and eutherians, and also on the homologous region of chicken chromosome 4, this represents a loss from the monotreme X rather than an additional evolutionary stratum of the human X. 相似文献
50.
Kamya MR Semitala FC Quinn TC Ronald A Njama-Meya D Mayanja-Kizza H Katabira ET Spacek LA 《African health sciences》2004,4(2):94-101