全文获取类型
收费全文 | 58篇 |
免费 | 6篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 1篇 |
基础医学 | 3篇 |
口腔科学 | 2篇 |
临床医学 | 7篇 |
内科学 | 14篇 |
神经病学 | 4篇 |
特种医学 | 4篇 |
外科学 | 17篇 |
综合类 | 1篇 |
预防医学 | 3篇 |
肿瘤学 | 1篇 |
出版年
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 1篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2010年 | 4篇 |
2009年 | 4篇 |
2008年 | 2篇 |
2007年 | 1篇 |
2006年 | 3篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有64条查询结果,搜索用时 473 毫秒
21.
重度卵巢过度刺激综合征1 3例临床分析 总被引:3,自引:0,他引:3
目的:总结重度卵巢过度刺激综合征(ovarian hy-perstimulation syndrome,OHSS)临床表现、发病机制及相应的治疗方法。方法:回顾性分析13例重度OHSS的临床资料。结果:重度OHSS发生在超排卵治疗后,临床表现为腹胀、恶心、腹水、胸水、少尿、血液浓缩、水电解质及酸碱平衡紊乱、氮质血症。经严密观察、输白蛋白、扩容及放胸腹水等治疗后治愈。移植日已出现OHSS者将胚胎冷冻保存。结论:防治重度OHSS的关键在于预防,一旦发生OHSS,经严密观察和及时治疗可治愈;迟发OHSS与妊娠有关。 相似文献
22.
Mosaicism in sporadic neurofibromatosis 2 patients 总被引:5,自引:1,他引:4
More than half of neurofibromatosis 2 (NF2) patients represent de novo
mutations which could have occurred at either pre-zygotic or post- zygotic
stages. A post-zygotic mutation can result in mosaicism. In four sporadic
NF2 patients, we found NF2 mutations in only a portion of corresponding
leukocytes. In two other sporadic patients, no mutations were found in
leukocytes but constitutional NF2 mutations were suggested by identical
mutations in different tumors from each patient. We screened leukocyte DNA
from a total of 16 inherited and 91 sporadic NF2 patients, and found NF2
mutations in 13 (81%) of the former and in 46 (51%) of the latter cases.
The 30% difference in the rate of detection of mutations ( P = 0.051) might
be partially explained by mosaicism in a portion of sporadic NF2 patients
who carry the mutations in such a fashion that their leukocytes are
unaffected. Among sporadic cases, we found mutations more frequently in
patients with severe phenotypes (59%) than in patients with mild phenotypes
(23%) (difference of 36%, P = 0.007). Mosaicism might be more common in the
latter patient group since small populations of mutation-bearing cells can
in some cases result in mild phenotypes and can also lead to difficulties
in identifying mutations. No mutations were found in eight patients
suspected of having NF2. Mosaicism with an extremely small population of
affected cells may explain the incomplete phenotypes in some of these
patients and the lack of mutations in their leukocytes. These findings
suggest that mosaicism is relatively common in NF2 and may have important
implications for diagnosis, prognosis and genetic counseling.
相似文献
23.
24.
Investigation of Compressible Electromagnetic Flute Mode Instability in Finite Beta Plasma in Support of Z-Pinch and Laboratory Astrophysics Experiments
下载免费PDF全文
![点击此处可从《Communications In Computational Physics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
V. I. Sotnikov V. V. Ivanov R. Presura J. N. Leboeuf O. G. Onishchenko B. V. Oliver B. Jones T. A. Mehlhorn & C. Deeney 《Communications In Computational Physics》2008,4(3):611-623
Flute mode turbulence plays an important role in numerous applications,
such as tokamak, Z-pinch, space and astrophysical plasmas. In a low beta plasma
flute oscillations are electrostatic and in the nonlinear stage they produce large scale
density structures co-mingling with short scale oscillations. Large scale structures are
responsible for the enhanced transport across the magnetic field and appearance of
short scales leads to ion heating, associated with the ion viscosity. In the present paper
nonlinear equations which describe the nonlinear evolution of the flute modes treated
as compressible electromagnetic oscillations in a finite beta inhomogeneous plasma
with nonuniform magnetic field are derived and solved numerically. For this purpose
the 2D numerical code FLUTE was developed. Numerical results show that even in
a finite beta plasma flute mode instability can develop along with formation of large
scale structures co-existing with short scale perturbations in the nonlinear stage. 相似文献
25.
GT Clark S Sakai R Merrill VF Flack C McCreary 《Cephalalgia : an international journal of headache》1995,15(6):511-518
Thirty-six tension-type headache subjects and 36 non-headache matched controls recorded their temporalis muscle electromyographic (EMG) activity and their pain intensity, stress and physical activity levels in a daily diary. Measurements were performed every 30 min for 6 days (EMG 3 days only). A time-lagged cross-correlational analysis between pain, stress, physical activity, and EMG shows that the highest correlation coefficient values occurred between pain and stress at the same ( r =0.33) and at the two preceding 0.5 h time points ( r =0.21 and r =0.26) in the headache group. Virtually no correlation was found between pain, stress, or physical activity with EMG for either group. These data show that temporalis muscle activity levels were not related to the rise and fall of the subjects' pain or stress levels. Conversely, elevated stress appeared to be highly related to pain; it occurs as both an antecedent and simultaneous event with elevated headache pain. 相似文献
26.
27.
Parthasarathy D. Thirumala Lance Bodily Derrick Tint W. Timothy Ward Vincent F. Deeney Donald J. Crammond Miguel E. Habeych Jeffrey R. Balzer 《The spine journal》2014,14(8):1572-1580
BackgroundIntraoperative monitoring (IOM) using somatosensory-evoked potentials (SSEPs) plays an important role in reducing iatrogenic neurologic deficits during corrective pediatric idiopathic procedures for scoliosis. However, for unknown reasons, recent reports have cited that the sensitivity of SSEPs to detect neurologic deficits has decreased, in some to be less than 50%. This current trend, which is coincident with the addition of transcranial motor-evoked potentials, is surprising given that SSEPs are robust, reproducible responses that were previously shown to have sensitivity and specificity of >90%.PurposeOur primary aim was to assess whether SSEPs alone can detect impending neurologic deficits with similar sensitivity and specificity as originally reported. Our secondary aim was to estimate the potential predictive value of adding transcranial motor-evoked potentials to SSEP monitoring in idiopathic scoliosis procedures.DesignThis was a retrospective review to analyze the efficacy of SSEP monitoring in the group of pediatric instrumented scoliosis fusion cases.Patient sampleWe retrospectively reviewed all consecutive cases of patients who underwent idiopathic scoliosis surgery between 1999 and 2009 at Children’s Hospital of Pittsburgh. We identified 477 patients who had the surgery with SSEP monitoring alone. Exclusion criteria included any patients with neuromuscular disorders or unreliable SSEP monitoring. Patients who had incomplete neurophysiology data or incomplete postoperative records were also excluded.Outcome measuresMajor outcomes measured were clinically significant postoperative sensory or motor deficits, as well as significant intraoperative SSEP changes.MethodsContinuous interleaved upper- and lower-extremity SSEPs were obtained throughout the duration of all procedures. We considered a persistent 50% reduction in primary somatosensory cortical amplitude or a prolongation of response latency by >10% from baseline to be significant. Persistent changes represent significant deviation in SSEP amplitude or latency in more than two consecutive averaged trials. Patients were classified into one of four categories with respect to SSEP monitoring: true positive, false positive, true negative, and false negative. The sensitivity, specificity, positive predictive value, and negative predictive value were then calculated accordingly.ResultsOur review of 477 idiopathic scoliosis surgeries monitored using SSEPs alone revealed a new deficit rate of 0.63% with no cases of permanent injury. Sensitivity = 95.0%, specificity = 99.8%, positive predictive value = 95%, negative predictive value = 99.8%. Using evidence-based epidemiologic measures, we calculated that the number needed to treat was 1,587 patients for one intervention to be performed that would have been missed by SSEP monitoring alone. In addition, the number needed to harm, which represents the increase in false positives with the addition of transcranial electrical motor-evoked potentials, was 200.ConclusionSSEP monitoring alone during idiopathic scoliosis continues to be a highly reliable method for the detection and prevention of iatrogenic injury. Our results confirm the high sensitivity and specificity of SSEP monitoring alone published in earlier literature. As such, we suggest the continued use of SSEP alone in idiopathic scoliosis surgeries. At this time we do not believe there are sufficient data to support the addition of MEP monitoring, although more studies and revised criteria for the use of MEP may provide added value for its use in the future. 相似文献
28.
We report two cases of primary ilio-psoas abscess in neonates diagnose by CT and sonography. Iliopsoas abscess is extremely uncommon in this age group. 相似文献
29.
30.
Quesniaux VF; Wehrli S; Steiner C; Joergensen J; Schuurman HJ; Herrman P; Schreier MH; Schuler W 《Blood》1994,84(5):1543-1552
The immunosuppressive drug rapamycin suppresses T-cell activation by impairing the T-cell response to lymphokines such as interleukin-2 (IL- 2) and interleukin-4 (IL-4). In addition, rapamycin blocks the proliferative response of cell lines to a variety of hematopoietic growth factors, including interleukin-3 (IL-3), interleukin-6 (IL-6), granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage- colony stimulating factor (GM-CSF), and kit ligand (KL), suggesting that it should be a strong inhibitor of hematopoiesis. In this report, we studied the effects of rapamycin on different hematopoietic cell populations in vitro and in vivo. In vitro, rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL. In vivo, treatment for 10 to 28 days with high doses of rapamycin (50 mg/kg/d, orally) had no effect on myelopoiesis in normal mice, as measured by bone marrow cellularity, proliferative capacity, and number of colony-forming progenitors. In contrast, the same treatment strongly suppressed the hematopoietic recovery normally seen 10 days after an injection of 5-fluorouracil (5- FU; 150 mg/kg, intravenously [i.v.]). Thus, rapamycin may be detrimental in myelocompromised individuals. In addition, the results suggest that the rapamycin-sensitive cytokine-driven pathways are essential for hematopoietic recovery after myelodepression, but not for steady-state hematopoiesis. 相似文献