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排序方式: 共有1599条查询结果,搜索用时 15 毫秒
61.
Chiara Mazzarelli Debora Angrisani Raffaella Viganò 《Clinical gastroenterology and hepatology》2021,19(6):1299-1300
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Debora Bevilaqua-Grossi Marilia Zanin Camila Benedetti Lidiane Florencio Anamaria Oliveira 《Physiotherapy theory and practice》2019,35(2):139-147
Objective: The aim was to assess sensitization using quantitative sensory testing in mechanical and thermal modes in individuals with and without osteoarthritis (OA) of the knee. Pain thresholds were correlated with functionality, symptoms of depression and intensity of pain. Methods: Thirty control volunteers and 30 patients with OA of the knee were assessed. Punctate pain thresholds using Von Frey filaments and thermal pain thresholds using a Thermal Sensory Analyzer were evaluated in the periarticular region of the knee and forearm. Using a digital pressure algometer, pressure pain thresholds were assessed in the periarticular region of the knee and on the root exit zone on the lumbar and sacral spine. Results: Punctate, pressure, and thermal pain thresholds differed significantly between participants with and without OA (p < 0.05). Values in those with OA were consistent with pain sensitization. Pressure pain thresholds also showed moderate and negative correlations with data on functionality, symptoms of depression and intensity of pain (?0.36 < r > ?0.56), contributing up to 30% of their variability. Conclusions: Allodynia and hyperalgesia were demonstrated in the OA group, suggesting central sensitization in patients with mild to moderate severity of joint damage. Correlation between mechanical hypersensitivity and psychosocial factors seems to be small, despite of its significance. 相似文献
63.
Langenbacher AD Dong Y Shu X Choi J Nicoll DA Goldhaber JI Philipson KD Chen JN 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(49):17699-17704
Cardiac fibrillation, a form of cardiac arrhythmia, is the most common cause of embolic stroke and death associated with heart failure. The molecular mechanisms underlying cardiac fibrillation are largely unknown. Here we report a zebrafish model for cardiac fibrillation. The hearts of zebrafish tremblor (tre) mutants exhibit chaotic movements and fail to develop synchronized contractions. Calcium imaging showed that normal calcium transients are absent in tre cardiomyocytes, and molecular cloning of the tre mutation revealed that the tre locus encodes the zebrafish cardiac-specific sodium-calcium exchanger (NCX) 1, NCX1h. Forced expression of NCX1h or other calcium-handling molecules restored synchronized heartbeats in tre mutant embryos in a dosage-dependent manner, demonstrating the critical role of calcium homeostasis in maintaining embryonic cardiac function. By creating mosaic zebrafish embryos, we showed that sporadic NCX1h-null cells were not sufficient to disrupt normal cardiac function, but clustered wild-type cardiomyocytes contract in unison in tre mutant hearts. These data signify the essential role of calcium homeostasis and NCX1h in establishing rhythmic contraction in the embryonic zebrafish heart. 相似文献
64.
Daniela Laricchiuta Laura Petrosini Fabrizio Piras Enrica Macci Debora Cutuli Chiara Chiapponi Antonio Cerasa Eleonora Picerni Carlo Caltagirone Paolo Girardi Stefano Maria Tamorri Gianfranco Spalletta 《Human brain mapping》2014,35(1):285-296
Personality traits are multidimensional traits comprising cognitive, emotional, and behavioral characteristics, and a wide array of cerebral structures mediate individual variability. Differences in personality traits covary with brain morphometry in specific brain regions, and neuroimaging studies showed structural or functional abnormalities of cerebellum in subjects with personality disorders, suggesting a cerebellar role in affective processing and an effect on personality characteristics. To test the hypothesis that cerebellar [white matter (WM) and cortex] volumes are correlated with scores obtained in the four temperamental scales of the Temperament and Character Inventory (TCI) by Cloninger, a total of 125 healthy participants aged 18–67 years of both genders (males = 52) completed the TCI and underwent magnetic resonance imaging. The scores obtained in each temperamental scale were associated with the volumes of cerebellar WM and cortex of right and left hemispheres separately by using linear regression analyses. In line with our hypothesis, novelty seeking (NS) scores were positively associated with WM and cortex cerebellar volumes. Harm avoidance (HA) scores were negatively associated with WM and cortex cerebellar volumes. The range of individual differences in NS and HA scores reflects the range of variances of cerebellar volumes. The present data indicating a cerebellar substrate for some personality traits extend the relationship between personality and brain areas to a structure up to now thought to be involved mainly in motor and cognitive functions, much less in emotional processes and even less in personality individual differences. Hum Brain Mapp 35:285–296, 2014. © 2012 Wiley Periodicals, Inc. 相似文献
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Mucopolysaccharidosis type IVA: Evidence of primary and secondary central nervous system involvement 下载免费PDF全文
68.
Daniela Laricchiuta Laura Petrosini Fabrizio Piras Debora Cutuli Enrica Macci Eleonora Picerni Chiara Chiapponi Carlo Caltagirone Gianfranco Spalletta 《Brain structure & function》2014,219(3):793-803
Novelty Seeking (NS) and Harm Avoidance (HA) temperamental traits are related to approaching or avoiding motivational circuits relying on the integrity and functionality of distributed brain areas implicated in arousal and action. The present study verified whether and how macro- and micro-structural variations of basal ganglia are correlated with scores obtained in the NS and HA temperamental scales of the Temperament and Character Inventory by Cloninger. To this aim, 125 healthy adults aged 18–67 years of both sexes completed the Temperament and Character Inventory and underwent a high-resolution T1-weighted magnetic resonance imaging and a diffusion tensor imaging using a 3T scanner. The scores obtained in the temperamental scales were associated with volumes, mean diffusivity and fractional anisotropy measures of basal ganglia of both hemispheres separately, by using linear regression analyses. We found increased bilateral caudate and pallidum volumes associated with higher NS scores, as well as increased mean diffusivity in the bilateral putamen associated with higher HA scores. Macro- and micro-structural variations of basal ganglia regions contribute to explain the biological variance associated with NS or HA personality phenotype. The present findings evidencing some brain-temperament relationships highlight the importance of obtaining macro- and micro-structural measures in relation to individual differences. 相似文献
69.
Betina Santos Tomaz Gabriela Carvalho Gomes Juliana Arcanjo Lino David Guabiraba Abitbol de Menezes Jorge Barbosa Soares Vasco Furtado Luiz Soares Júnior Maria do Socorro Quintino Farias Debora Lilian Nascimento Lima Eanes Delgado Barros Pereira Marcelo Alcantara Holanda 《Jornal brasileiro de pneumologia》2022,48(1)
70.
Formánek Martin Walderová Radana Baníková Šárka Chmelová Irina Formánková Debora Zeleník Karol Komínek Pavel 《European archives of oto-rhino-laryngology》2020,277(3):933-938
European Archives of Oto-Rhino-Laryngology - Electrical stimulation-supported therapy is an often used modality. However, it still belongs to experimental methods in the human larynx. Data are... 相似文献