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Bone erosion in synovial chondromatosis 总被引:7,自引:0,他引:7
Of 30 patients with synovial chondromatosis, nine had prominent pressure defects at the articular margins of the hip and shoulder. Erosions of bone may be extensive, and the patient can be at risk for developing a pathologic fracture. Synovial chondromatosis should be considered in the differential diagnosis of lesions causing erosions of the articular ends of the bones; it is not as uncommon as has been previously suggested. 相似文献
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Curhan GC Willett WC Speizer FE Stampfer MJ 《Journal of the American Society of Nephrology : JASN》1999,10(4):840-845
Urinary oxalate is an important determinant of calcium oxalate kidney stone formation. High doses of vitamin B6 may decrease oxalate production, whereas vitamin C can be metabolized to oxalate. This study was conducted to examine the association between the intakes of vitamins B6 and C and risk of kidney stone formation in women. The relation between the intake of vitamins B6 and C and the risk of symptomatic kidney stones were prospectively studied in a cohort of 85,557 women with no history of kidney stones. Semiquantitative food-frequency questionnaires were used to assess vitamin consumption from both foods and supplements. A total of 1078 incident cases of kidney stones was documented during the 14-yr follow-up period. A high intake of vitamin B6 was inversely associated with risk of stone formation. After adjusting for other dietary factors, the relative risk of incident stone formation for women in the highest category of B6 intake (> or =40 mg/d) compared with the lowest category (<3 mg/d) was 0.66 (95% confidence interval, 0.44 to 0.98). In contrast, vitamin C intake was not associated with risk. The multivariate relative risk for women in the highest category of vitamin C intake (> or =1500 mg/d) compared with the lowest category (<250 mg/d) was 1.06 (95% confidence interval, 0.69 to 1.64). Large doses of vitamin B6 may reduce the risk of kidney stone formation in women. Routine restriction of vitamin C to prevent stone formation appears unwarranted. 相似文献
388.
SB HEBBANDI JR BOWEN GC HIPWELL PJ MA GI LESLIE JD ARNOLD 《Journal of paediatrics and child health》1997,33(4):339-342
Objective To report long-term ophthalmological sequelae in extremely premature infants at 5 years and to determine the relationship between neonatal variables (including retinopathy of prematurity; ROP) and the 5 year ophthalmological outcome of these infants.
Methodology The study cohort comprised 84 surviving infants born with a birthweight <1000 g or gestational age <28 weeks from June 1985 to December 1989. All infants had an ophthalmological assessment between 34 and 40 weeks post conceptional age to document grade of ROP and were assessed at 5 years of age for fundoscopy, visual acuity, refractive error and ocular mobility.
Results Of the 84 long-term survivors 69 (82%) were formally assessed at 5 years. Overall, 30 (43%) had some form of ocular disorder. Nineteen (27%) had reduced visual acuity of <6/6 and three of these were blind. Myopia > −0.5 dioptre was noted in eight (12%), hypermetropia ≥2.0 dioptre in five (8%), astigmatism in seven (11%) and strabismus was present in nine (14%) of the cohort. There was a significant relationship ( P <0.0001) between the incidence of ocular disorders and ROP. However, even those premature children without ROP had a 31% incidence of ocular disorder at 5 years.
Conclusion Long-term ophthalmological follow-up is recommended in all extremely premature infants regardless of the presence of ROP in the neonatal period. 相似文献
Methodology The study cohort comprised 84 surviving infants born with a birthweight <1000 g or gestational age <28 weeks from June 1985 to December 1989. All infants had an ophthalmological assessment between 34 and 40 weeks post conceptional age to document grade of ROP and were assessed at 5 years of age for fundoscopy, visual acuity, refractive error and ocular mobility.
Results Of the 84 long-term survivors 69 (82%) were formally assessed at 5 years. Overall, 30 (43%) had some form of ocular disorder. Nineteen (27%) had reduced visual acuity of <6/6 and three of these were blind. Myopia > −0.5 dioptre was noted in eight (12%), hypermetropia ≥2.0 dioptre in five (8%), astigmatism in seven (11%) and strabismus was present in nine (14%) of the cohort. There was a significant relationship ( P <0.0001) between the incidence of ocular disorders and ROP. However, even those premature children without ROP had a 31% incidence of ocular disorder at 5 years.
Conclusion Long-term ophthalmological follow-up is recommended in all extremely premature infants regardless of the presence of ROP in the neonatal period. 相似文献
389.
SK Sharma S Mukhopadhyay R Arora K Varma JN Pande GC Khilnani 《Journal of Medical Imaging and Radiation Oncology》1996,40(2):113-118
Computed tomography (CT) of the chest, pulmonary function tests, bronchoalveolar lavage (BAL) and arterial blood gas analysis were performed in 26 patients with non-HIV miliary tuberculosis (MTB). CT was repeated after treatment in 11 patients. Nodular lesions were characteristically seen on CT. CT showed discrete and fine nodules in five patients in whom the lesions appeared to be larger than miliary on chest X-rays. Coalescing nodular lesions were noted on chest X-rays (n= 7) and CT (n= 18). Consolidation (n= 6), cavitation (n= 4), fibrosis (n= 9) and air trapping (n= 14) were detected on CT only. During follow up, air trapping increased h = 14) and in some patients it appeared for the first time (n= 2). Lymph node enlargement and calcification were seen on both chest X-rays (n= 9 and (n= 3, respectively) and CT (n= 12 and n= 7, respectively). Pleural involvement was also seen in chest X-rays (n= 4) and CT (n= 5). Total lung capacity was higher in patients with a chest X-ray score > 10. Similarly a higher total cell count in BAL fluid was observed in patients with a CT score > 10. It is concluded from this study that CT is superior to chest X-rays in detecting nodular lesions, lymphadenopathy and air trapping in patients with MTB. 相似文献
390.
Bizzaro D; Manicardi GC; Bianchi PG; Bianchi U; Mariethoz E; Sakkas D 《Molecular human reproduction》1998,4(2):127-132
In this study we investigated the relationship between the presence of
bound protamine on mouse and human sperm DNA and the level of chromomycin
A3 (CMA3) and 4'6-diamidino-2-phenylindole (DAPI) fluorescence. This was
accomplished by performing a competition assay between salmon protamine and
fluorochromes on decondensed spermatozoa that had their nuclear proteins
extracted and were fixed on slides. Various concentrations (0, 0.005,
0.0225, 0.05, 0.225, 0.5 and 5 mg/ml) of salmon protamine were added to
either the CMA3 or DAPI staining solutions. Fluorescence emission
measurements of stained sperm nuclei were then performed using a
microfluorometer. When the treated decondensed sperm heads were stained
with either CMA3 or DAPI all spermatozoa were found to fluoresce intensely.
The addition of protamines to the spermatozoa led to an elimination of CMA3
fluorescence, while the intensity of DAPI staining was decreased to
approximately 50% at the highest concentrations of protamine. The addition
of increasing amounts of salmon protamine also induced the sperm nuclei to
regain their initial condensed appearance. This study shows that protamine
retains a strong affinity for sperm DNA in situ and that CMA3 fluorescence
is a strong indicator of the protamination state of spermatozoa.
相似文献