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排序方式: 共有569条查询结果,搜索用时 15 毫秒
561.
PA Arunkumar GL Viswanatha N Radheshyam H Mukund MS Belliyappa 《Asian Pacific Journal of Tropical Biomedicine》2012,2(8):640-644
Objective
To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.Methods
We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes, creatinine, blood urea nitrogen (BUN) and urine potassium, sodium and pH levels before and after the cisplatin chemotherapy. All the patients had cancer and were treated with 40-50 mg/day cisplatin. Renal injury was assessed by measuring serum electrolytes, creatinine, BUN levels and urine potassium, sodium and pH levels.Results
The five cycles of cisplatin based chemotherapy resulted in hypomagnesia (P=0.029), hypocalcaemia (P=0.001*), hypophosphatemia (P=0.003*), hypokalemia (P=0.001*) and increased serum creatinine (P=0.001*) and BUN (P=0.292*) levels. In urine analysis, decrease in potassium (P=0.024*) was found, except potassium there was no significant changes in sodium and urine pH.Conclusions
The present study demonstrates that, acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances, when no corrective measures were initiated. 相似文献562.
The present paper deals with Proctophantastes nettastomatis (Digenea: Zoogonidae; Lepidophyllinae) found in the intestine of three species of deep-sea fish, Dicrolene longimana (Ophidiidae, Ophidiiformes), Bathyuroconger sp. (Congridae, Anguilliformes), and Venefica tentaculata (Nettastomatidae, Anguilliformes). The fish were collected near the islands of Espiritu Santo, Erromango, and Epi, respectively,
in the archipelago of Vanuatu (Southern Pacific Ocean) at depths ranging from 561 to 990 m. Morphological and histological
analyses showed that the Vanuatu specimens differ from Proctophantastes abyssorum, Proctophantastes gillissi, Proctophantastes glandulosum, Proctophantastes infundibulum, and Proctophantastes brayi but are close to P. nettastomatis discovered in Suruga Bay, Japan. P. nettastomatis is redescribed based both on the observations of our specimens and of the Japanese holotype and paratype. The morphological
variability of the species is described. Morphometric data allowed the identification of positive allometric growth for the
hindbody, negative allometric growth for the ventral sucker, and a growth phenotypic plasticity between Ophidiiformes and
Anguilliformes definitive hosts. 相似文献
563.
VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar 《Asian Pacific Journal of Tropical Biomedicine》2011,1(2):142-146
Objective
To evaluate the hepatoprotective potential of Hepax, a polyherbal formulation, against three experimentally induced hepatotoxicity models in rats.Methods
Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models, namely, carbon tetrachloride (CCl4), paracetamol and thiocetamide induced hepatotoxicity in rats.Results
Administration of hepatotoxins (CCl4, paracetamol and thiocetamide) showed significant morphological, biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters (liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters (SGPT, SGOT, ALP and total bilirubin), which were evidently showed in histopathological study.Conclusions
The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg, p.o. on the liver of all the three experimental animal models. 相似文献564.
Erik F Hensen Jeroen C Jansen Maaike D Siemers Jan C Oosterwijk Annette HJT Vriends Eleonora PM Corssmit Jean-Pierre Bayley Andel GL van der Mey Cees J Cornelisse Peter Devilee 《European journal of human genetics : EJHG》2010,18(1):62-66
Germline mutations in SDHD predispose to the development of head and neck paragangliomas, and phaeochromocytomas. The risk of developing a tumor depends on the sex of the parent who transmits the mutation: paragangliomas only arise upon paternal transmission. In this study, both the risk of paraganglioma and phaeochromocytoma formation, and the risk of developing associated symptoms were investigated in 243 family members with the SDHD.D92Y founder mutation. By using the Kaplan–Meier method, age-specific penetrance was calculated separately for paraganglioma formation as defined by magnetic resonance imaging (MRI) and for paraganglioma-related signs and symptoms. Evaluating clinical signs and symptoms alone, the penetrance reached a maximum of 57% by the age of 47 years. When MRI detection of occult paragangliomas was included, penetrance was estimated to be 54% by the age of 40 years, 68% by the age of 60 years and 87% by the age of 70 years. Multiple tumors were found in 65% and phaeochromocytomas were diagnosed in 8% of paraganglioma patients. Malignant paraganglioma was diagnosed in one patient (3%). Although the majority of carriers of a paternally inherited SDHD mutation will eventually develop head and neck paragangliomas, we find a lower penetrance than previous estimates from studies based on predominantly index cases. The family-based study described here emphasizes the importance of the identification and inclusion of clinically unaffected mutation carriers in all estimates of penetrance. This finding will allow a more accurate genetic counseling and warrants a ‘wait and scan'' policy for asymptomatic paragangliomas, combined with biochemical screening for catecholamine excess in SDHD-linked patients. 相似文献
565.
566.
567.
高效液相色谱法对四种双氯灭痛软膏剂透皮效果的研究 总被引:2,自引:0,他引:2
目的:本实验采用高效液相色谱法,以离体小白鼠腹部皮肤为透皮屏障,比较了四种双氯灭痛软膏剂的透皮效果,方法:实验用法国Gilson公司的HPLC仪,以C18为固定相,甲醇-水(含HAc 0.36%)=80:20为流动相,紫外检测波长280nm。平均回收率为99.59%,RSD<3.28%,检测限为1.0ug/ml。结果:1号样品透皮率最高,3号与1号相比较透皮吸收无显著性差异(P>0.05),2号或4号分别与1号相比,其透皮吸收均有显著性差异(P<0.05),结论:1号品值得进一步开发。 相似文献
568.
569.
Benjamin I. Cribb MBChB FRACS Joseph C. Kong MBChB FRACS MS PhD James S. Kay MBBS GradDipSc Teng H. Tan MBSS MMed MIPH FRANZCR Geertje D. Noe MD FRANZCR Bibiche Gest FRANZCR MD Allan B. Lee MBBS BMed Sci FRANZCR Sheng F. Oon MBBCh FFRRCSI MD Satish K. Warrier MBBS MS FRACS Alexander G. Heriot MBA FRACS MD 《ANZ journal of surgery》2023,93(1-2):196-205