全文获取类型
收费全文 | 1023篇 |
免费 | 57篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 99篇 |
妇产科学 | 9篇 |
基础医学 | 95篇 |
口腔科学 | 19篇 |
临床医学 | 117篇 |
内科学 | 212篇 |
皮肤病学 | 32篇 |
神经病学 | 33篇 |
特种医学 | 128篇 |
外科学 | 121篇 |
综合类 | 39篇 |
预防医学 | 89篇 |
眼科学 | 30篇 |
药学 | 29篇 |
1篇 | |
肿瘤学 | 29篇 |
出版年
2023年 | 6篇 |
2022年 | 6篇 |
2021年 | 18篇 |
2020年 | 11篇 |
2019年 | 13篇 |
2018年 | 15篇 |
2017年 | 8篇 |
2016年 | 14篇 |
2015年 | 20篇 |
2014年 | 24篇 |
2013年 | 28篇 |
2012年 | 18篇 |
2011年 | 24篇 |
2010年 | 45篇 |
2009年 | 36篇 |
2008年 | 34篇 |
2007年 | 55篇 |
2006年 | 46篇 |
2005年 | 41篇 |
2004年 | 46篇 |
2003年 | 37篇 |
2002年 | 33篇 |
2001年 | 27篇 |
2000年 | 25篇 |
1999年 | 27篇 |
1998年 | 44篇 |
1997年 | 53篇 |
1996年 | 41篇 |
1995年 | 22篇 |
1994年 | 35篇 |
1993年 | 24篇 |
1992年 | 17篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 30篇 |
1988年 | 21篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 6篇 |
1984年 | 16篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 11篇 |
1980年 | 8篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1969年 | 2篇 |
1946年 | 2篇 |
1921年 | 1篇 |
排序方式: 共有1085条查询结果,搜索用时 15 毫秒
111.
Development of the Manchester framework for the evaluation of emergency department pharmacy services
Greenwood D Tully MP Martin S Steinke D 《International journal of clinical pharmacy》2022,44(4):930-938
International Journal of Clinical Pharmacy - Many countries, including the United Kingdom, have established Emergency Department (ED) pharmacy services where some ED pharmacists now work as... 相似文献
112.
Treatment of vitiligo with topical imiquimod 总被引:1,自引:0,他引:1
113.
F Gallardo MP García-Muret O Servitje T Estrach I Bielsa A Salar E Abella C Barranco RM Pujol 《Journal of the European Academy of Dermatology and Venereology》2009,23(6):639-647
Background The presence of a prominent granulomatous tissue reaction in skin biopsies from primary cutaneous or systemic malignant lymphomas with secondary cutaneous involvement is a rare but well-known phenomenon.
Objective This paper aims to characterize and study a series of cutaneous lymphomas showing a prominent granulomatous component.
Patients and methods The clinical, histopathological and evolutive features of granulomatous variants of mycosis fungoides (5 patients, 2 of them associating 'granulomatous slack skin' features), Sézary syndrome (1 patient), CD30+ cutaneous T-cell lymphoma (2 patients), CD4+ small/medium pleomorphic cutaneous T-cell lymphoma (1 patient), primary cutaneous B-cell lymphoma (3 patients) and peripheral T-cell lymphoma with secondary epithelioid granulomatous cutaneous involvement (4 patients) were reviewed.
Results The observed features were clinically non-distinctive. Only those cases presenting with granulomatous slack skin features were clinically suspected (2 patients). Non-necrotizing granulomata (11 patients) and granuloma annulare-like (4 patients) were the most frequently observed histopathological patterns. In five cases, no diagnostic lymphomatous involvement was initially observed. From our series, no definite conclusions regarding prognosis could be established.
Conclusion The diagnosis of cutaneous lymphoma may be difficult when a prominent cutaneous granulomatous inflammatory infiltrate obscures the true neoplastic nature of the condition. However, the presence of concomitant lymphoid atypia may help to suspect the diagnosis. In doubtful cases, the clinical evolution and the demonstration of a monoclonal lymphoid B- or T-cell population may lead to a definite diagnosis.
None declared. 相似文献
Objective This paper aims to characterize and study a series of cutaneous lymphomas showing a prominent granulomatous component.
Patients and methods The clinical, histopathological and evolutive features of granulomatous variants of mycosis fungoides (5 patients, 2 of them associating 'granulomatous slack skin' features), Sézary syndrome (1 patient), CD30
Results The observed features were clinically non-distinctive. Only those cases presenting with granulomatous slack skin features were clinically suspected (2 patients). Non-necrotizing granulomata (11 patients) and granuloma annulare-like (4 patients) were the most frequently observed histopathological patterns. In five cases, no diagnostic lymphomatous involvement was initially observed. From our series, no definite conclusions regarding prognosis could be established.
Conclusion The diagnosis of cutaneous lymphoma may be difficult when a prominent cutaneous granulomatous inflammatory infiltrate obscures the true neoplastic nature of the condition. However, the presence of concomitant lymphoid atypia may help to suspect the diagnosis. In doubtful cases, the clinical evolution and the demonstration of a monoclonal lymphoid B- or T-cell population may lead to a definite diagnosis.
Conflicts of interest
None declared. 相似文献
114.
115.
116.
REMATCH Investigators William L. Holman MD Soon J. Park MD James W. Long MD PhD Alan Weinberg MS Lopa Gupta RD MPH Anita R. Tierney MPH Robert M. Adamson MD John D. Watson MD Edward P. Raines MD JD Gregory S. Couper MD Francis D. Pagani MD PhD Nelson A. Burton MD Leslie W. Miller MD Yoshifumi Naka MD PhD 《The Journal of heart and lung transplantation》2004,23(12):E84-1365
117.
ST O'Sullivan MD FRCSI GT McGreal FRCS CM Reardon FRCSI DJ Hehir MCH FRCSI WO Kirwan MCH FRCSI MP Brady MCH FRCSI 《International journal of clinical practice》1997,51(5):289-292
During a four-year period, 308 patients presented following ingestion of foreign bodies. Ingestion was accidental in 272 cases (88.3%) and deliberate in the remainder. Symptoms at presentation included dysphagia, odynophagia, nausea and vomiting, chest pain and pharyngeal discomfort. Sixty-eight patients were asymptomatic. A policy of expectant management and selective endoscopy was employed. Following initial assessment 202 patients (65.6%) were discharged without treatment, 30 (9.7%) of whom were later reviewed as outpatients and did not require admission. Forty-nine patients (16%) were admitted for treatment; 27 had oesophagoscopy, five bronchoscopy and two had foreign body extraction with direct laryngoscopy. In nine patients who were endoscoped, no foreign body was identified. Twenty-seven others were referred to the otorhinolaryngology service in another hospital. There were no deaths in the group and morbidity was 1.2%. We conclude that a policy of selective endoscopy is safe and effective in the management of patients following ingestion of foreign bodies. 相似文献
118.
SANMIGUEL CP HAGIIKE M MINTCHEV MP DELA CRUZ R PHILLIPS E CUNNEEN SA CONKLIN JL SOFFER EE 《Neurogastroenterology and motility》2006,18(6):484-485
Background: Electrical stimulation (ES) of the stomach has been shown to modulate LESP. Electrical stimulation, using neural high frequency stimulation (NGES) can induce contractions of the smooth muscle of the gut. The purpose of this study was to determine if electrical stimulation of the LES can affect LESP. Methods: Four female hound dogs, weight: 20–25 kg, underwent an esophagostomy that allowed the introduction of a sleeve manometry catheter into the esophagus. They were also implanted with a pair of electrodes along the longitudinal axis of the LES. After 3 weeks of recovery, they underwent esophageal manometry recording during control and ES, performed randomly on separate days, using 4 different stimulations: 1‐Low frequency: freq: 6 cycles/min, pulse: 350 milisec, amp: 5 mAmp; 2 High‐frequency: freq: 50 Hz, pulse: 1 milisec, amp: 5 mAmp; 3‐ NGES: freq: 50 Hz, pulse:20 milisec, amp:10 volts; 4‐ High‐frequency, circular: freq: 20 Hz, pulse:1 milisec, amp:5 mAmp. All recordings were performed 1 hour after consumption of 3 ounces of canned dog food, to prevent fluctuations in LESP and under mild sedation (acepromazine 0.5 mg kg1). Tests consisted, during ES days, of 3 periods of 20 minutes each: control , stimulation and post stimulation. The effect of NGES was also tested under anesthesia and following administration of L‐NAME 50 mg kg1 IV. and also atropine 0.05 mg kg1 IV. Analysis: area under the curve (AUC) and pressure were compared among the 3 periods. Data shown as mean ± SD, ANOVA and t‐test, p < 0.05. Results: Sustained increase in LESP was observed during low frequency stimulation, 32.1 ± 12.8 vs. 42.4 ± 18.0 vs. 50.1 ± 23.6, control vs. stimulation vs. post stimulation respectively, p = 0.013. AUC also significantly increased during and after stimulation, 39,320.3 ± 15,722 vs. 51,294 ± 21,826 vs. 59,823.6 ± 28,198.4 mmHgxsec, control vs. stimulation vs. post stimulation respectively, p = 0.01. There was no significant change with other types of ES. NGES induced an initial rise in LESP followed within few seconds by relaxation with slow resumption of pressure over a 1 minute period. L‐NAME increased LESP and augmented the initial rise in LESP following NGES but markedly diminished or abolished the relaxation phase. Atropine lowered LESP and abolished the initial rise in LESP induced by NGES. Conclusions: Low frequency ES of the LES increases LESP in conscious dogs. NGES has dual effect on LESP: an initial stimulation, cholinergically mediated, followed by relaxation mediated by nitric oxide. 相似文献
119.
We examined the incidence and spectrum of pancreatic disease in pediatric systemic lupus erythematosus (SLE). We measured serum immunoreactive cationic trypsinogen (IRT) in 185 samples obtained from 35 patients with SLE. Fifteen patients (43%) had elevated IRT levels on at least one occasion. Serum samples were obtained in 20 of 35 patients before start of treatment. Seven of these 20 patients (35%) had elevated IRT levels at diagnosis, which slowly returned to normal as their disease was controlled with treatment. A further 3 of these 20 patients in whom we had sera at diagnosis had elevated levels at some course during their illness. Of the remaining 15 patients in whom sera was not available at diagnosis, 5 patients had increased IRT levels on at least one occasion. We show that elevated IRT levels are common in pediatric SLE, but there was no apparent association with drugs such as prednisone and azathioprine. However, high levels of IRT at the time of diagnosis may be related to an underlying disease component such as vasculitis. 相似文献
120.
Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study 总被引:5,自引:0,他引:5
Pankow JS Kwan DK Duncan BB Schmidt MI Couper DJ Golden S Ballantyne CM 《Diabetes care》2007,30(2):325-331
OBJECTIVE: We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals. RESEARCH DESIGN AND METHODS: The study included 6,888 participants aged 52-75 years who had no history of diabetes or CVD. All-cause mortality and incident CHD were ascertained over a median of 6.3 years of follow-up. RESULTS: Agreement between fasting and postchallenge glucose impairment was poor: 3,048 subjects (44%) had neither impaired fasting glucose (IFG) nor impaired glucose tolerance (IGT), 1,690 (25%) had isolated IFG, 1,000 (14%) had isolated IGT, and 1,149 (17%) had both IFG and IGT. After adjustment for age, sex, race, and center, subjects with isolated IFG were more likely to smoke, consume alcohol, and had higher mean BMI, waist circumference, LDL cholesterol, and fasting insulin and lower HDL cholesterol than those with isolated IGT, while subjects with isolated IGT had higher mean triglycerides, systolic blood pressure, and white cell counts. Measures of subclinical CVD and rates of all-cause mortality and incident CHD were similar in isolated IFG and isolated IGT. CONCLUSIONS: Neither isolated IFG nor isolated IGT was associated with a more adverse CVD risk profile. 相似文献