High lead exposure and auditory sensory-neural function in Andean children.

We investigated blood lead (B-Pb) and mercury (B-Hg) levels and auditory sensory-neural function in 62 Andean school children living in a Pb-contaminated area of Ecuador and 14 children in a neighboring gold mining area with no known Pb exposure. The median B-Pb level for 62 children in the Pb-exposed group was 52.6 micrograms/dl (range 9.9-110.0 micrograms/dl) compared with 6.4 micrograms/dl (range 3.9-12.0 micrograms/dl) for the children in the non-Pb exposed group; the differences were statistically significant (p < 0.001). Auditory thresholds for the Pb-exposed group were normal at the pure tone frequencies of 0.25-8 kHz over the entire range of B-Pb levels, Auditory brain stem response tests in seven children with high B-Pb levels showed normal absolute peak and interpeak latencies. The median B-Hg levels were 0.16 micrograms/dl (range 0.04-0.58 micrograms/dl) for children in the Pb-exposed group and 0.22 micrograms/dl (range 0.1-0.44 micrograms/dl) for children in the non-Pb exposed gold mining area, and showed no significant relationship to auditory function.     

Evidence of udder excretion of Campylobacter jejuni as the cause of milk-borne campylobacter outbreak.

We describe a community outbreak of campylobacter enteritis associated with the consumption of untreated milk, apparently contaminated by two cows with campylobacter mastitis. The outbreak occurred in two phases. Strains of Campylobacter jejuni of the Penner serogroup complex 4, 13, 16, 50 and Preston biotype code 6100 were isolated from patients in both episodes and from the faeces of the cattle, milk filters, bulk milk and retail milk. Milk samples from two of 40 milking cows were found to contain C. jejuni, and the wheys from these two cows had high titres of antibody to C. jejuni detected by ELISA techniques.     

Pinealectomy affects the diurnal variations in 2－［~（125）I］ iodomelatonin binding sites in chicken bursa of Fabricius

Ｐｉｎｅａｌｅｃｔｏｍｙａｆｆｅｃｔｓｔｈｅｄｉｕｒｎａｌｖａｒｉａｔｉｏｎｓｉｎ２－［~（１２５）Ｉ］ｉｏｄｏｍｅｌａｔｏｎｉｎｂｉｎｄｉｎｇｓｉｔｅｓｉｎｃｈｉｃｋｅｎｂｕｒｓａｏｆＦａｂｒｉｃｉｕｓＺｈａｏＹｉｎｇ（赵瑛）；ＰｏｏｎＡＭＳ，Ｐａ?..     

3H-1,2-二氢-1-吡里酮衍生物的合成

发现3 H-1,2-二氢-1-吡咯里嗪酮具有明显的抗炎镇痛作用。用Friedel-Crafts酰化和Dieckmann缩合等反应制备了该酮的一些衍生物,其中五个未见于文献报道。药理实验证明,这些化合物均有不同程度的抗炎镇痛作用。     

PREVALENCE OF MITRAL VALVE PROLAPSE IN HONG KONG CHINESE A CLINICAL AND AUTOPSY STUDY

The prevalence of mitral valve pro.lapse in Chinese was determined by screening 156 heal- thy subjects and by patholobic examination of 86 adult autopsies. Mitral valve prolapse was found in 7.7% in the clinical study and 5.8% in the autopsy study. A slight female preponderance was noted.     

Gallbladder and bile duct stones: percutaneous therapy with primary MTBE dissolution and mechanical methods

The authors describe percutaneous treatment of gallbladder or bile duct stones in 18 patients who were poor surgical candidates or in whom conventional therapy failed. Dissolution was performed in most cases with methyl tert-butyl ether (MTBE) because of its potent dissolution properties; other solvents used included monooctanoin or chelating solutions. Gallbladder stones were eliminated in 11 of 13 patients (six of seven with dissolution alone, four of four with dissolution and basket extraction, one with basket removal alone). In five patients with stones in the common bile duct (n = 3), cystic duct remnant (n = 1), and intrahepatic bile ducts (n = 1), stones were eliminated with dissolution alone in two and with dissolution plus basket extraction in one. In two patients percutaneous therapy failed due to complications (vagal hypotension with bile peritonitis and transient respiratory arrest) that occurred during catheter placement. Preliminary results suggest that MTBE is effective for dissolution of many gallbladder stones and some bile duct stones. Noncholesterol solvents and adjuvant mechanical maneuvers are valuable adjuncts to achieve complete stone elimination.     

脑益嗪对实验性脑血栓形成及血小板聚集的抑制作用

本文报道脑益嗪对大鼠实验性脑血栓形成及兔血小板聚集的抑制作用。经大鼠颈动脉顺行注射复合血栓诱导剂造成脑血栓模型,测定伊文思兰通过血脑屏障渗入脑实质的量以反映脑血栓的严重程度。结果表明脑益嗪(67 mg/kg,灌胃)有抗脑血栓形成的作用。半体内实验表明脑益嗪(34 mg/kg,灌胃)可抑制兔血小板聚集。