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121.
122.
The haemodynamic and respiratory effects of intravenous nimodipine used in the treatment of eclampsia 总被引:3,自引:0,他引:3
J. Anthony Senior Consultant G. Mantel Consultant R. Johanson Consultant J. Dommisse Head of Department 《BJOG : an international journal of obstetrics and gynaecology》1996,103(6):518-522
Objective To establish the antihypertensive properties of intravenous nimodipine used to treat eclamptic patients. To assess the effects of intravenous nimodipine on oxygen delivery and consumption.
Design A prospective observational study.
Setting The Maternity Centre Obstetric Intensive Care Unit, Groote Schuur Hospital.
Participants Four unselected patients presenting with proteinuric hypertension and seizures.
Methods Haemodynamic observations were obtained by a radial artery catheter and right heart catheterisation with a pulmonary artery flow directed thermodilution catheter. Observations were obtained prior to and after the administration of nimodipine.
Resuts A significant reduction in mean arterial pressure occurred in all patients after administration of nimodipine. This was due to a significant reduction in systemic vascular resistance. Neither oxygen delivery to the tissues nor peripheral oxygen consumption changed significantly during nimodipine infusion. No adverse effects related to the use of nimodipine were documented.
Conclusions Nimodipine is an effective vasodilator. There may be a role for nimodipine as a single agent for the management of eclampsia. 相似文献
Design A prospective observational study.
Setting The Maternity Centre Obstetric Intensive Care Unit, Groote Schuur Hospital.
Participants Four unselected patients presenting with proteinuric hypertension and seizures.
Methods Haemodynamic observations were obtained by a radial artery catheter and right heart catheterisation with a pulmonary artery flow directed thermodilution catheter. Observations were obtained prior to and after the administration of nimodipine.
Resuts A significant reduction in mean arterial pressure occurred in all patients after administration of nimodipine. This was due to a significant reduction in systemic vascular resistance. Neither oxygen delivery to the tissues nor peripheral oxygen consumption changed significantly during nimodipine infusion. No adverse effects related to the use of nimodipine were documented.
Conclusions Nimodipine is an effective vasodilator. There may be a role for nimodipine as a single agent for the management of eclampsia. 相似文献
123.
Double-blind evaluation of ritodrine sustained release for oral maintenance of tocolysis after active preterm labour 总被引:1,自引:0,他引:1
C. A. G. Holleboom Consultant J. M. W. M. Merkus Professor L. W. M. van Elferen Scientific Oficer‡ M. J. N. C. Keirse Professor ‡ 《BJOG : an international journal of obstetrics and gynaecology》1996,103(7):702-705
Objective To evaluate the effect of ritodrine sustained release capsules for maintaining uterine quiescence after successful treatment of active preterm labour.
Design Multicentre placebo-controlled trial. Setting Five teaching hospitals in the Netherlands.
Participants Women ( n = 95 ) at less than 35 weeks of gestation in whom active preterm labour had been stopped with intravenous ritodrine.
Interventions Women received either two 40 mg ritodrine sustained release capsules ( n = 50 ) or identical placebo capsules ( n = 45 ) three times a day for seven days.
Results The proportion of women who received another course of active treatment was significantly smaller with the sustained release than with placebo (1 of 50 versus 11 of 45: P = 0.003 ) as was the number delivering because of preterm labour during treatment (0 of 50 versus 4 of 45: P = 0.04 ). There were no other significant differences between the two groups.
Conclusions Maintenance treatment with ritodrine sustained release capsules after arrest of preterm labour reduces the risk of recurrences of preterm labour that necessitate treatment or precipitate delivery. 相似文献
Design Multicentre placebo-controlled trial. Setting Five teaching hospitals in the Netherlands.
Participants Women ( n = 95 ) at less than 35 weeks of gestation in whom active preterm labour had been stopped with intravenous ritodrine.
Interventions Women received either two 40 mg ritodrine sustained release capsules ( n = 50 ) or identical placebo capsules ( n = 45 ) three times a day for seven days.
Results The proportion of women who received another course of active treatment was significantly smaller with the sustained release than with placebo (1 of 50 versus 11 of 45: P = 0.003 ) as was the number delivering because of preterm labour during treatment (0 of 50 versus 4 of 45: P = 0.04 ). There were no other significant differences between the two groups.
Conclusions Maintenance treatment with ritodrine sustained release capsules after arrest of preterm labour reduces the risk of recurrences of preterm labour that necessitate treatment or precipitate delivery. 相似文献
124.
A comparison of bladder and ovarian function two years following hysterectomy or endometrial ablation 总被引:3,自引:0,他引:3
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A longitudinal study of bacterial vaginosis during pregnancy 总被引:7,自引:0,他引:7
P. E. Hay Honorary Senior Registrar D. J. Morgan Research Fellow C. A. Ison Lecturer S. A. Bhide Clinical Assistant M. Romney Research Sister P. McKenzie Research Assistant J. Pearson Statistician R. F. Lamont Consultant D. Taylor-Robinson Professor 《BJOG : an international journal of obstetrics and gynaecology》1994,101(12):1048-1053