Causes of death in the extremely low birth weight infant

OBJECTIVE: To present primary and secondary causes of death confirmed by autopsy for the extremely low birth weight infant. METHODS: A total of 111 infants weighing between 300 and 1000 g at birth who died and were autopsied at our hospital during the 4-year period 1990-1993 were retrospectively reviewed. Clinical, pathologic, and laboratory data were retrieved including results of placental examinations and autopsy cultures. Primary and secondary causes of death were assigned by the authors. RESULTS: Infection was the most common primary cause (56/111) followed by respiratory distress syndrome/bronchopulmonary dysplasia (24/111) and congenital defect (15/111). Immaturity as an only cause appeared almost exclusively in infants weighing <500 g at birth. Infection was significantly underdiagnosed clinically with most of these deaths attributed to immaturity or respiratory distress syndrome. In only 1 case was intraventricular hemorrhage considered the primary cause of death although it was present as a secondary cause in 19/111. Infections were divided into congenital (30/56) and acquired (26/56) by time of death. The congenital infections (相似文献   

盐酸洛美沙星片的工艺改进

目的：为了进一步提高盐酸洛美沙星片溶出与吸收性能。方法：采用微粉化及新型片剂辅料。结果：制备了高效盐酸洛美沙星薄膜衣片。结论：经对照检验,结果溶出度较市售品显著加速。