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排序方式: 共有1053条查询结果,搜索用时 15 毫秒
201.
202.
Widawski L. Fabacher T. Spielmann L. Gottenberg JE. Sibilia J. Duret PM. Messer L. Felten R. 《Clinical rheumatology》2022,41(5):1421-1429
Clinical Rheumatology - To study the impact of hyperuricemia on clinical presentation, severity, and associated comorbidities of psoriatic arthritis (PsA). Retrospective bicentric... 相似文献
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SC Gandevia GM Allen JE Butler RB Gorman DK McKenzie 《Clinical and experimental pharmacology & physiology》1998,25(10):757-763
1. Given the importance of the ventilatory ‘pump’ muscles, it would not be surprising if they were endowed with both sensory and motor specializations. The present review focuses on some unexpected properties of the respiratory muscle system in human subjects. 2. Although changes in blood gas tension were long held not to influence sensation directly, studies in subjects who are completely paralysed show that increases in arterial CO2 levels elicit strong sensations of respiratory discomfort. 3. Stretch reflexes in human limb muscles contain a monosynaptic spinal excitation and a long-latency excitation. However, inspiratory muscles show an initial inhibition when tested with brief airway occlusions during inspiration. This inhibition does not depend critically on input from pulmonary or upper airway receptors. 4. Human inspiratory muscles (including the diaphragm) have been considered to fatigue during inspiratory resistive loading. However, recent studies using phrenic nerve stimulation to test the force produced by the diaphragm show that carbon dioxide retention (hypoventilation) and voluntary cessation of loading occur before the muscles become overtly fatigued. 相似文献
206.
Modulation of liver tumor blood flow with hepatic arterial epinephrine: a SPECT study 总被引:3,自引:0,他引:3
Changes in the relative arterial flow to hepatic tumors and adjacent normal liver, in response to varied doses of hepatic arterial epinephrine, were studied with single photon emission computed tomography. In 18 patients with known hepatic tumors, hepatic artery perfusion scans were obtained with the concurrent infusion of technetium-99m-labeled macroaggregated albumin and escalating doses of epinephrine (0-10 micrograms/min). Regions of interest were drawn around tumor and adjacent normal liver in three planes, and the average tumor-to-liver ratio (T:L) was calculated. In all 18 patients, there was a measurable baseline T:L perfusion advantage (range, 1.7-18.7; mean, 4.8). In 12 of 18 patients, this ratio increased with epinephrine (range, 1.1-53.6 times the baseline value; mean, 7.1). In six patients, no improvement in T:L could be demonstrated. In 14 patients the lung shunt index, a measurement of arteriovenous shunting, increased with escalating doses of epinephrine. This pilot study suggests that the infusion of epinephrine may improve the therapeutic index of certain regional therapies such as bolus drug infusions, hepatic arterial embolization, and radioactive microsphere therapy. 相似文献
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Lee FT Jr; Chosy SG; Naidu SG; Goldfarb S; Weichert JP; Bakan DA; Kuhlman JE; Tambeaux RH; Sproat IA 《Radiology》1997,203(2):465
209.
JE Osborne PE Hutchinson 《Journal of the European Academy of Dermatology and Venereology》2002,16(4):367-373
Little attention is given to accurate dosage of topical medication which is a potential source of side-effects and treatment failure. There are studies on the dosage for 'sparing' application relevant to topical steroids but not for 'liberal' application. Though calcipotriol is a first line topical treatment for psoriasis, approximately one-third of patients do not respond adequately. The aims of the present study were to define liberal dosage, to develop a method of calculation of area of involved skin and to evaluate the efficacy of calcipotriol in optimized liberal dosages, based on preliminary studies, in calcipotriol treatment failures. Weight/unit area of ointment and cream base, constituting liberal application, was determined in six normal volunteers. The area of psoriatic involvement in 24 calcipotriol non-responders was estimated by a 'fill-up' method and a modified 'hand' method. The results of the two methods were similar (Pearson correlation coefficient 0.68, P < 0.0001) but the 'hand' method proved easier in use and was the preferred method for the rest of the study. The patients applied calcipotriol at their accustomed rates for at least 2 weeks and then at the calculated liberal rates, using cream in the morning and ointment at night, for 4 weeks. The efficacy measures were Psoriasis Area and Severity Index (PASI) (primary measure), a four-point efficacy score and a visual analogue scale. As a result of the preliminary study and the actual amounts used by the patients in the psoriasis treatment study reported below, liberal application has been defined as 50 g/m2 per application for ointment base and 40 g/m2 per application for cream. At this dosage, an average individual would use approximately 100 g of medication/week to treat 10% of the body surface. During the 4-week treatment study, the psoriasis patients used an average of 39 g (SD 17 g)/m2 per application of cream and 52 g (SD 13 g)/m2 per application of ointment. All efficacy measures showed marked improvement (P < 0.0001). The frequency distribution of the PASI reduction defined responsive (70% of patients) and poorly responsive groups (30%), with mean PASI reduction of 60% and 17%, respectively. 相似文献
210.
The relation between women's age and fertility, and the factors that
influence the age at which couples desire to have their first child, were
analysed in a national sample of women aged 25-49 years. A random sample of
8050 households in the Netherlands was approached. In these households,
3295 women between the ages of 25 and 49 years answered a short
questionnaire about planning their first pregnancy and about fertility.
Furthermore, sociodemographic data were gathered. There appeared to be
almost no variation in cumulative pregnancy rate between age 20 and 28:
between 65 and 70% at 6 months, just below 90% at 12 months and
approximately 93% at 24 months. After the age of 33 years, the cumulative
pregnancy rate at 6 months decreased. From the age of 28 years the
cumulative pregnancy rate at 12 months and at 24 months decreased
gradually, reaching 75 and 80% respectively, by the age of 35 years. The
year of birth of the woman (the 'time' factor) was the most important
factor influencing the age at which couples desired to have their first
child. In addition, demographic factors, particularly a high level of
education, a high professional level and a high level of family income,
were associated with the desire to have the first child at a relatively
late age.
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