全文获取类型
收费全文 | 417篇 |
免费 | 17篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 10篇 |
妇产科学 | 7篇 |
基础医学 | 16篇 |
口腔科学 | 6篇 |
临床医学 | 27篇 |
内科学 | 169篇 |
皮肤病学 | 3篇 |
神经病学 | 10篇 |
特种医学 | 15篇 |
外科学 | 92篇 |
综合类 | 6篇 |
预防医学 | 17篇 |
眼科学 | 7篇 |
药学 | 10篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 22篇 |
2020年 | 7篇 |
2019年 | 17篇 |
2018年 | 8篇 |
2017年 | 9篇 |
2016年 | 9篇 |
2015年 | 7篇 |
2014年 | 14篇 |
2013年 | 19篇 |
2012年 | 34篇 |
2011年 | 31篇 |
2010年 | 13篇 |
2009年 | 20篇 |
2008年 | 28篇 |
2007年 | 18篇 |
2006年 | 16篇 |
2005年 | 15篇 |
2004年 | 18篇 |
2003年 | 13篇 |
2002年 | 22篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 7篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 13篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1954年 | 1篇 |
1930年 | 1篇 |
1909年 | 1篇 |
1906年 | 1篇 |
排序方式: 共有434条查询结果,搜索用时 15 毫秒
101.
102.
103.
Observational study of corrected count increments after transfusion of platelets treated with riboflavin pathogen reduction technology in additive solutions 下载免费PDF全文
104.
105.
Alan S Go Chirag R Parikh T Alp Ikizler Steven Coca Edward D Siew Vernon M Chinchilli Chi-yuan Hsu Amit X Garg Michael Zappitelli Kathleen D Liu W Brian Reeves Nasrollah Ghahramani Prasad Devarajan Georgia Brown Faulkner Thida C Tan Paul L Kimmel Paul Eggers John B Stokes 《BMC nephrology》2010,11(1):1-13
Background
The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors.Methods
The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardiovascular events, death, and other important patient-centered outcomes. This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers. Participants will be followed for up to four years, and will undergo serial evaluation during the index hospitalization, at three months post-hospitalization, and at annual clinic visits, with telephone interviews occurring during the intervening six-month intervals. Biospecimens will be collected at each visit, along with information on lifestyle behaviors, quality of life and functional status, cognitive function, receipt of therapies, interim renal and cardiovascular events, electrocardiography and urinalysis.Conclusions
ASSESS-AKI will characterize the short-term and long-term natural history of AKI, evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI, and identify a subset of high-risk patients who could be targeted for future clinical trials to improve outcomes after AKI. 相似文献106.
107.
Pérez-Persona E Vidriales MB Mateo G García-Sanz R Mateos MV de Coca AG Galende J Martín-Nuñez G Alonso JM de Las Heras N Hernández JM Martín A López-Berges C Orfao A San Miguel JF 《Blood》2007,110(7):2586-2592
Monoclonal gammopathy of uncertain significance (MGUS) and smoldering multiple myeloma (SMM) are plasma cell disorders with a risk of progression of approximately 1% and 10% per year, respectively. We have previously shown that the proportion of bone marrow (BM) aberrant plasma cells (aPCs) within the BMPC compartment (aPC/BMPC) as assessed by flow cytometry (FC) contributes to differential diagnosis between MGUS and multiple myloma (MM). The goal of the present study was to investigate this parameter as a marker for risk of progression in MGUS (n = 407) and SMM (n = 93). Patients with a marked predominance of aPCs/BMPC (> or = 95%) at diagnosis displayed a significantly higher risk of progression both in MGUS and SMM (P< .001). Multivariate analysis for progression-free survival (PFS) selected the percentage aPC/BMPC (> or = 95%) as the most important independent variable, together with DNA aneuploidy and immunoparesis, for MGUS and SMM, respectively. Using these independent variables, we have identified 3 risk categories in MGUS (PFS at 5 years of 2%, 10%, and 46%, respectively; P< .001) and SMM patients (PFS at 5 years of 4%, 46%, and 72%, respectively; P < .001). Our results show that multiparameter FC evaluation of BMPC at diagnosis is a valuable tool that could help to individualize the follow-up strategy for MGUS and SMM patients. 相似文献
108.
We describe a 34-year-old man who presented with headaches for about 3 months. Magnetic Resonance Imaging (MRI) revealed a
large cystic tumor, involving the right frontoparietal lobe region. Pathological study revealed a papillary glioneuronal tumor
(PGNT) with mitotic activity and a Ki-67 labeling index of approximately 15%. Five years after radical surgery and radiotherapy,
the patient is symptom-free, without tumor recurrence or residual tumor. This case supports the existence of an atypical variant
of PGNT, with mitotic activity and high proliferative index, and suggests that in these tumors, histological findings of malignity
not necessarily indicate a short-term unfavorable behavior. 相似文献
109.
Gorostidi M Sobrino J Segura J Sierra C de la Sierra A Hernández del Rey R Vinyoles E Galcerán JM López-Eady MD Marín R Banegas JR Sarría A Coca A Ruilope LM;Spanish Society of Hypertension ABPM Registry investigators 《Journal of hypertension》2007,25(5):977-984
OBJECTIVE: To evaluate ambulatory blood pressure monitoring (ABPM) parameters in a broad sample of high-risk hypertensive patients. METHODS: The Spanish Society of Hypertension is developing a nationwide project in which more than 900 physicians send ABPM registries and corresponding clinical records to a central database via www.cardiorisc.com. Between June 2004 and July 2005 a 20 000-patient database was obtained; 17 219 were valid for analysis. RESULTS: We identified 6534 patients with high cardiovascular risk according to the 2003 European Society of Hypertension/European Society of Cardiology guidelines stratification score. Office blood pressure (BP) was 158.8/89.9 mmHg and 24-h BP was 135.8/77.0 mmHg. Patients with grade 3 BP in the office showed ambulatory systolic BP values less than 160 mmHg in more than 80%. A non-dipping pattern was observed in 3836 cases (58.7%), whereas this abnormality was present in 47.9% of patients with low-to-moderate risk [odds ratio (OR) 1.54; 95% confidence interval (CI) 1.45-1.64]. The prevalence of non-dippers was higher as ambulatory BP increased ( approximately 70% when 24-h systolic BP > 155 mmHg) and was similar in both groups. At the lowest levels of BP (24-h systolic BP < 135 mmHg) a non-dipping pattern was more prevalent in high-risk cases (56.6 versus 45.7%; OR 1.51; 95% CI 1.40-1.64). CONCLUSION: There was a remarkable discrepancy between office and ambulatory BP in high-risk hypertensive patients. The prevalence of a non-dipper BP pattern was almost 60%. In the lowest levels of ambulatory BP, high-risk patients showed a higher prevalence of non-dipping BP than lower-risk cases. These observations support the recommendation of a wider use of ABPM in high-risk hypertensive patients. 相似文献
110.