全文获取类型
收费全文 | 5541篇 |
免费 | 544篇 |
国内免费 | 87篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 125篇 |
妇产科学 | 249篇 |
基础医学 | 701篇 |
口腔科学 | 65篇 |
临床医学 | 570篇 |
内科学 | 1146篇 |
皮肤病学 | 92篇 |
神经病学 | 429篇 |
特种医学 | 350篇 |
外科学 | 778篇 |
综合类 | 124篇 |
预防医学 | 320篇 |
眼科学 | 101篇 |
药学 | 401篇 |
中国医学 | 26篇 |
肿瘤学 | 653篇 |
出版年
2023年 | 31篇 |
2022年 | 54篇 |
2021年 | 126篇 |
2020年 | 98篇 |
2019年 | 179篇 |
2018年 | 181篇 |
2017年 | 123篇 |
2016年 | 141篇 |
2015年 | 182篇 |
2014年 | 216篇 |
2013年 | 328篇 |
2012年 | 385篇 |
2011年 | 384篇 |
2010年 | 268篇 |
2009年 | 215篇 |
2008年 | 298篇 |
2007年 | 312篇 |
2006年 | 268篇 |
2005年 | 286篇 |
2004年 | 259篇 |
2003年 | 231篇 |
2002年 | 222篇 |
2001年 | 175篇 |
2000年 | 148篇 |
1999年 | 150篇 |
1998年 | 50篇 |
1997年 | 42篇 |
1996年 | 36篇 |
1995年 | 32篇 |
1994年 | 21篇 |
1993年 | 28篇 |
1992年 | 83篇 |
1991年 | 81篇 |
1990年 | 55篇 |
1989年 | 52篇 |
1988年 | 54篇 |
1987年 | 51篇 |
1986年 | 44篇 |
1985年 | 48篇 |
1984年 | 41篇 |
1983年 | 23篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 12篇 |
1978年 | 16篇 |
1977年 | 12篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1969年 | 9篇 |
排序方式: 共有6172条查询结果,搜索用时 31 毫秒
111.
112.
Chi‐Yuan Chen Shih‐Hwa Chiou Chih‐Yang Huang Chia‐Ing Jan Shu‐Chun Lin Wen‐Yuan Hu Shiu‐Huey Chou Chung‐Ji Liu Jeng‐Fan Lo 《The Journal of pathology》2009,219(3):347-355
Human tumourous imaginal disc (Tid1), a human homologue of the Drosophila tumour suppressor protein Tid56, is involved in multiple intracellular signalling pathways such as apoptosis, cell proliferation, and cell survival. Here, we investigated the anti‐tumourigenic activity of Tid1 in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. Firstly, the clinical association between Tid1 expression and progression of HNSCC was explored. It was found that expression of Tid1 was negatively associated with tumour status, recurrence, and survival prognosis using immunohistochemical analysis of primary HNSCC patient tumour tissue. Secondly, ectopic expression of Tid1 in HNSCC cells was shown to significantly inhibit cell proliferation, migration, invasion, anchorage‐independent growth, and xenotransplantation tumourigenicity. Thirdly, we showed that overexpression of Tid1 attenuated EGFR activity and blocked the activation of AKT in HNSCC cells, which are known to be involved in the regulation of survival in HNSCC cells. On the other hand, ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression. Together, these findings suggest that Tid1 functions as a tumour suppressor in HNSCC tumourigenesis. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
113.
Chang NC Shih CM Bi WF Lai ZY Lin MS Wang TC 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2002,16(2):141-147
To clarify whether fosinopril monotherapy can improve left ventricular diastolic function (LVDF) in young mildly hypertensives without hypertrophy, we studied 66 patients (pts) with diastolic blood pressure 90–100 mmHg, aged <45 years, with normal 2-dimensional echocardiography (2-D echo), and impaired DF. Impaired DF was defined as a Doppler transmitral early (E) to atrial (A) filling velocity ratio (E/A ratio) <1. Thirty-eight pts were selected for fosinopril monotherapy. Mean age was 36 years. Duration of documented hypertension was 5.4 years. Mean daily dose of fosinopril was 20 mg. Twenty-eight controls were treated with hydrochlorothiazide and hydralazine combination. Sixty-six age- and sex-matched healthy subjects served to establish normal reference values of 2-D and Doppler echo measurements. All hypertensives were treated for 30 months and re-examined 4 weeks after cessation of treatment. The fosinopril-treated group showed improvements in transmitral E (52 ± 8 cm/s, vs. 61 ± 9 cm/s, p < 0.01), A (56 ± 9 cm/s, vs. 47 ± 6 cm/s, p < 0.05), and E/A ratio (0.93 ± 0.16, vs. 1.29 ± 0.18, p < 0.01). Moreover, the early to atrial velocity-time integral ratio (1.31 ± 0.10, vs. 2.24 ± 0.10, p < 0.001) improved. The pulmonary venous flow pattern normalized after fosinopril therapy. LV mass index, relative wall thickness, LV dimension, left atrial dimension, fractional shortening, heart rate, and body mass index did not change. The hydrochlorothiazide-hydralazine combination-treated group did not show an improved diastolic function. It is concluded that long-term fosinopril monotherapy leads to an improvement of impaired LVDF in young mildly hypertensives without hypertrophy. 相似文献
114.
Shira H. Fischer MD PhD Regina A. Shih PhD Tara L. McMullen PhD Maria O. Edelen PhD Sangeeta C. Ahluwalia PhD Emily K. Chen PhD Sarah E. Dalton MA Susan Paddock PhD Anthony Rodriguez PhD Debra Saliba MD MPH AGSF Stella Mandl BSW BSN RN Teresa Mota BSN RN Advisory Group on Medication Reconciliation in PAC 《Journal of the American Geriatrics Society》2022,70(4):1047-1056
115.
Chin-Han Lin Shao-Hua Yu Chih-Yu Chen Fen-Wei Huang Wei-Kung Chen Hong-Mo Shih 《Medicine》2021,100(17)
Metabolic acidosis is observed in 98% of patients with out-of-hospital cardiac arrest (OHCA). The longer the no-flow or low-flow duration, the more severe is the acidosis in these patients. This study explored whether blood pH in early stages of advanced life support (ALS) was an independent predictor of neurological prognosis in patients with OHCA.We retrospectively enrolled patients with OHCA from January 2012 to June 2018 in a single-medical tertiary hospital in Taiwan. Patients with OHCA whose blood gas analyses within 5 minutes after receiving ALS at the emergency department (ED) were enrolled. Patients younger than 20 years old, with cardiac arrest resulting from traumatic or circumstantial causes, with return of spontaneous circulation (ROSC) before ED arrival, lacking record of initial blood gas analysis, and with do-not-resuscitate orders were excluded. The primary outcome of this study was neurological status at hospital discharge.In total, 2034 patients with OHCA were enrolled. The majority were male (61.89%), and the average age was 67.8 ± 17.0 years. Witnessed OHCA was noted in 571 cases, cardiopulmonary resuscitation was performed before paramedic arrival in 512 (25.2%) cases, and a shockable rhythm was observed in 269 (13.2%). Blood pH from initial blood gas analysis remained an independent predictor of neurological outcome after multivariate regression.Blood pH at early stages of ALS was an independent prognostic factor of post-OHCA neurological outcome. Blood gas analysis on arrival at the ED may provide additional information about the prognosis of patients with OHCA. 相似文献
116.
Alpha‐phellandrene‐induced DNA damage and affect DNA repair protein expression in WEHI‐3 murine leukemia cells in vitro
下载免费PDF全文
![点击此处可从《Environmental toxicology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jen‐Jyh Lin Chih‐Chung Wu Shu‐Chun Hsu Shu‐Wen Weng Yi‐Shih Ma Yi‐Ping Huang Jaung‐Geng Lin Jing‐Gung Chung 《Environmental toxicology》2015,30(11):1322-1330
Although there are few reports regarding α‐phellandrene (α‐PA), a natural compound from Schinus molle L. essential oil, there is no report to show that α‐PA induced DNA damage and affected DNA repair associated protein expression. Herein, we investigated the effects of α‐PA on DNA damage and repair associated protein expression in murine leukemia cells. Flow cytometric assay was used to measure the effects of α‐PA on total cell viability and the results indicated that α‐PA induced cell death. Comet assay and 4,6‐diamidino‐2‐phenylindole dihydrochloride staining were used for measuring DNA damage and condensation, respectively, and the results indicated that α‐PA induced DNA damage and condensation in a concentration‐dependent manner. DNA gel electrophoresis was used to examine the DNA damage and the results showed that α‐PA induced DNA damage in WEHI‐3 cells. Western blotting assay was used to measure the changes of DNA damage and repair associated protein expression and the results indicated that α‐PA increased p‐p53, p‐H2A.X, 14‐3‐3‐σ, and MDC1 protein expression but inhibited the protein of p53, MGMT, DNA‐PK, and BRCA‐1. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 1322–1330, 2015. 相似文献
117.
118.
119.
Molecular basis of weak D in Taiwanese 总被引:4,自引:0,他引:4
Two genes, RHD and RHCE, encode the antigens of the RH blood group system. The weak D phenotype is caused by many different RHD alleles encoding aberrant RhD proteins, resulting in distinct serologic phenotypes and anti-D immunization. We analyzed seven weak D phenotypes excluding Del, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing methods to detect the changes of all ten RHD exons. The results show that there are four types of weak D in Taiwanese: one case each for CGG to CAG mutation at codon 10, GTG to ATG mutation at codon 174, and GTG to GAG mutation at codon 270, and four cases for GGT to GAT mutation at codon 282. In conclusion, we present the first data of a molecular basis of weak D in Taiwanese, which suggest a clinically relevant potential for anti-D immunization and may improve transfusion strategy in weak D Taiwanese patients. 相似文献
120.
Angiotensin 1‐7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway
下载免费PDF全文
![点击此处可从《European journal of clinical investigation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Yen‐Yu Lu Wen‐Shiann Wu Yung‐Kuo Lin Chen‐Chuan Cheng Yao‐Chang Chen Shih‐Ann Chen Yi‐Jen Chen 《European journal of clinical investigation》2018,48(1)