全文获取类型
收费全文 | 15400篇 |
免费 | 1103篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 102篇 |
儿科学 | 360篇 |
妇产科学 | 207篇 |
基础医学 | 2237篇 |
口腔科学 | 152篇 |
临床医学 | 1553篇 |
内科学 | 3963篇 |
皮肤病学 | 236篇 |
神经病学 | 1325篇 |
特种医学 | 624篇 |
外国民族医学 | 1篇 |
外科学 | 2404篇 |
综合类 | 58篇 |
一般理论 | 4篇 |
预防医学 | 868篇 |
眼科学 | 220篇 |
药学 | 1137篇 |
中国医学 | 24篇 |
肿瘤学 | 1085篇 |
出版年
2023年 | 79篇 |
2022年 | 161篇 |
2021年 | 396篇 |
2020年 | 207篇 |
2019年 | 352篇 |
2018年 | 429篇 |
2017年 | 297篇 |
2016年 | 327篇 |
2015年 | 409篇 |
2014年 | 563篇 |
2013年 | 756篇 |
2012年 | 1211篇 |
2011年 | 1249篇 |
2010年 | 719篇 |
2009年 | 618篇 |
2008年 | 1031篇 |
2007年 | 1068篇 |
2006年 | 1006篇 |
2005年 | 1015篇 |
2004年 | 943篇 |
2003年 | 907篇 |
2002年 | 779篇 |
2001年 | 148篇 |
2000年 | 116篇 |
1999年 | 163篇 |
1998年 | 166篇 |
1997年 | 132篇 |
1996年 | 97篇 |
1995年 | 78篇 |
1994年 | 75篇 |
1993年 | 73篇 |
1992年 | 82篇 |
1991年 | 47篇 |
1990年 | 66篇 |
1989年 | 53篇 |
1988年 | 45篇 |
1987年 | 35篇 |
1986年 | 37篇 |
1985年 | 35篇 |
1984年 | 33篇 |
1983年 | 38篇 |
1982年 | 29篇 |
1981年 | 21篇 |
1980年 | 30篇 |
1979年 | 18篇 |
1978年 | 29篇 |
1974年 | 20篇 |
1973年 | 21篇 |
1932年 | 19篇 |
1931年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Sequential 99mTc-hydrazinonicotinamide-annexin V imaging for predicting response to chemotherapy. 总被引:1,自引:0,他引:1
Sylvie Rottey Guido Slegers Simon Van Belle Ingeborg Goethals Christophe Van de Wiele 《Journal of nuclear medicine》2006,47(11):1813-1818
This study was undertaken to evaluate changes in relative (99m)Tc-hydrazinonicotinamide (HYNIC)-annexin V tumor uptake over time in patients undergoing chemotherapeutic treatment at baseline and at 5-7 h and 40-44 h after treatment initiation. Imaging results are related to clinical outcomes, as assessed with response evaluation criteria in solid tumors (RECIST). METHODS: We prospectively included 20 patients (11 men and 9 women; mean age, 59.8 y; range, 22-75 y) scheduled for chemotherapy (n = 19) or bisphosphonate treatment (n = 1). Curable disease was present in 5 patients. The other patients had metastatic disease and were treated in a palliative setting. Three of the 20 enrolled patients were excluded from analysis: 1 patient ultimately refused the proposed chemotherapy treatment; because of difficulties with the labeling procedure, 1 patient did not receive a pretreatment scan; and 1 patient presented with an allergic reaction (rash and nausea) to the (99m)Tc-HYNIC-annexin V formulation. The remaining 17 patients underwent 3 scintigraphic scans with (99m)Tc-HYNIC-annexin V: before treatment and 5-7 h and 40-44 h after treatment initiation. The tumor response was evaluated with RECIST and related to observed changes in the ratios of tumor activity to background activity for the largest known lesion; values exceeding 25% the baseline value on either the 5- to 7-h scan or the 40- to 44-h scan were considered significant. RESULTS: With the proposed sequential imaging protocol and a 25% change threshold, responders to treatment could be separated from nonresponders with a 94% accuracy (16/17 patients). CONCLUSION: Sequential (99m)Tc-HYNIC-annexin V imaging may allow for assessment of the response to chemotherapy within 3 d after treatment initiation. 相似文献
22.
Emmanuel Lansac Isabelle Di Centa Nicolas Bonnet Pascal Leprince Akthar Rama Christophe Acar Alain Pavie Iradj Gandjbakhch 《European journal of cardio-thoracic surgery》2006,29(4):537-544
OBJECTIVE: Dilation of aortic annulus, sinuses of Valsalva, and sinotubular junction (STJ) diameters are the characteristic lesions of aortic root aneurysm. The remodeling technique reduces STJ diameter and creates three neosinuses of Valsalva. Alternatively, the reimplantation technique reduces both annulus and STJ diameters to the detriment of aortic root dynamics. Although the remodeling technique is recognized as the most physiological valve-sparing procedure, aortic annulus dilation may jeopardize its results. A standardized approach that combines an external subvalvular aortic prosthetic ring annuloplasty with the remodeling technique is suggested. METHODS: Eighty-three patients underwent an elective aortic root remodeling procedure, either isolated (group 1, n=34) or combined with an external subvalvular aortic prosthetic ring annuloplasty (group 2, n=49). Preoperative aortic regurgitation was 1.59+/-1.1 (group 1) and 1.97+/-1.3 (group 2) (NS). The aortic annulus was more dilated in group 2 than in group 1 (27+/-2.77 mm vs 26.4+/-2.3 mm, p<0.01). Residual aortic regurgitation > or =grade II was the conversion criteria for aortic valve replacement. RESULTS: Operative mortality was 3.6% (n=3). Intraoperative conversion for valve replacement was 32.7% in group 1 (n=11) versus 4.2% in group 2 (n=2) (p<0.001). In group 1, preoperative annulus diameter was larger for converted than for valve-spared patients (27.6+/-1.7 mm vs 25.2+/-1.5 mm, p<0.02). In group 2, implanted aortic ring significantly reduced annulus diameter (20.6+/-1.8 mm) without significant aortic valve gradient (8.3+/-3 mmHg). Follow-up was 17.2+/-13.4 months (group 1) and 10.41+/-7.95 months (group 2). Reoperation for recurrent aortic regurgitation was 13% in group 1 (n=3) versus 4.2% in group 2 (n=2). Echocardiographic follow-up found residual aortic regurgitation < or =grade I in 17 patients in group 1 (90%) versus 43 patients in group 2 (95.5%) and of grade II in two patients in group 1 (10%) and two patients in group 2 (4.5%). CONCLUSION: The addition of external aortic prosthetic ring annuloplasty improves the remodeling technique's operative reproducibility and short-term results. Therefore, its use as a systematical adjunct to the remodeling procedure is suggested. However, further long-term evaluation comparing this valve-sparing procedure to composite graft replacement should define the best surgical strategy for aortic root aneurysm. 相似文献
23.
24.
Stroke-induced hemiballismus (HB) has been reported to improve motor function in people with Parkinson's disease (PD). We report on a patient who developed HB from a parietal infarct. The HB was improved by very low-dose clozapine but the HB did not improve the parkinsonism. This suggests that HB itself, whether from a lesion in the subthalamic nucleus or elsewhere, is not what improves motor function in PD; instead, the physiological function of the damaged structure is the determining factor. 相似文献
25.
Louis Bernard Christophe Sadowski Daniel Monin Richard Stern Blaise Wyssa Peter Rohner Daniel Lew Pierre Hoffmeyer 《Infection control and hospital epidemiology》2004,25(6):512-514
OBJECTIVE: To determine whether bacterial cultures of the wounds of patients undergoing clean orthopedic surgery would help predict infection. METHODS: During 1 year, 1,256 cultures were performed for 1,102 patients who underwent clean orthopedic surgery. Results were analyzed to evaluate their ability to predict postoperative infection. RESULTS: The sensitivity, specificity, positive predictive value, and negative predictive value of the cultures were 38%, 92%, 7%, and 99%, respectively. CONCLUSIONS: Cultures performed during clean orthopedic surgery were not useful for predicting postoperative infection. 相似文献
26.
This study investigated the temporal evolution in the discrimination of the newborn's crying by the mother, from the first to the eighth day after birth. The sample included twenty human mothers who had had an uneventful pregnancy, labour and delivery. They were asked to identify the spontaneous cries of their newborn babies from tape-recorded cries containing cries from their own newborn and from three other newborns. On the first day, the percentage of correct answers was 48#pc, then 81 #pc on the eighth day. Two acoustic features that may underlie this discrimination were analyzed: the maximum Fo values and the average number of cry bursts per second. On the seventh day, these two acoustic variables and the discrimination abilities significantly correlate. 相似文献
27.
Claude Clément MD Roberto Ruiz MD Bogdan Costa-Foru MD Hubert Nicaise MD 《Annals of vascular surgery》1990,4(3):305-308
Extrinsic compression of the renal artery due to a fibromuscular band originating from the diaphragm was encountered in a 26-year-old patient who had systemic hypertension associated with stenosis and kinking of one of her renal arteries. After surgical decompression, the renal artery assumed a normal expansion with disappearance of hypertension. Six other cases of extrinsic compression of the renal artery have been found in the literature. Surgical treatment is mandatory in all cases because the mechanism that causes the lesion makes percutaneous transluminal angioplasty illusory. 相似文献
28.
29.
Kimberly M Miller Michael S Okun Hubert F Fernandez Charles E Jacobson Ramon L Rodriguez Dawn Bowers 《Movement disorders》2007,22(5):666-672
Depression is common in Parkinson's disease (PD) and affects 30 to 50% of all patients. In contrast to the wealth of research on depression in PD, little is known about the occurrence of depression in other movement disorders. The primary objective of the current study was to determine whether the high prevalence of depression symptoms seen in PD is also found in other movement disorders, by directly comparing rates of specific depression symptoms and depression severity across PD, dystonia, and essential tremor (ET). Three hundred and fifty-four patients with PD, 83 patients with dystonia, and 53 patients with ET completed the Beck Depression Inventory (BDI). We found no significant between-groups differences for depression severity, frequency, or endorsement of specific depression symptoms. Forty-eight percent of PD patients, 37.3% of dystonia patients, and 34% of ET patients were found to be at least mildly depressed (BDI score of 10 or higher). The most commonly endorsed symptoms were fatigability, difficulty with work, anhedonia, and sleep disturbance. Clinicians should be aware that depression is a frequent problem in dystonia and ET, in addition to PD, and inquire about depression symptoms in these patients so that they can be appropriately treated. 相似文献
30.
A Küster P Jouvet D Bonnet C Flandin R Lenclein P Hubert D Jan 《Zeitschrift für Kinderchirurgie》2003,13(5):294-297
Twenty-two premature neonates underwent surgical haemoclip closure of patent ductus arteriosus in a neonatal intensive care unit (NICU). Surgery was performed in the NICU in order to prevent hypothermia and interruption of care, and to avoid accidental vascular access removal and extubation. The results suggest that morbidity can be limited by performing the surgery in an NICU, and by switching from conventional to high-frequency mechanical ventilation in case of severe respiratory failure. 相似文献