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991.
992.
Byung-Taek Choi Dae-Young Hwang Gye-Hyeong Lee Da-Nal Moon Kyung-Min Lee 《The Angle orthodontist》2019,89(6):924
Objectives:To evaluate condylar movement during lateral excursion in individuals with internal derangement of the temporomandibular joint (TMJ) using ultrasonic axiography.Materials and Methods:A total of 34 patients with internal derangement of the TMJ and 34 participants in the control group were examined. Mandibular functional movement was recorded by ultrasonic axiography. Three-dimensional condylar movement was measured in the working and balancing condyles.Results:Significant differences in condylar movement were found between the two groups. In the group with internal derangement of the TMJ, the three-dimensional linear distances of the condylar path in a working condyle were greater than in the control group during lateral excursion. The speed of the balancing condyle in the returning path of lateral excursion was significantly greater in the group with internal derangement than in the control group.Conclusions:The results of the present study indicate that internal derangement of TMJ may affect the working and balancing condylar movements during lateral excursion. 相似文献
993.
994.
Nirpesh Adhikari Sanjiv Neupane Yam Prasad Aryal Mi Choi Wern‐Joo Sohn Youngkyun Lee Jae‐Kwang Jung Jung‐Hong Ha So‐Young Choi Jo‐Young Suh Ji‐Youn Kim Mun‐Chual Rho Tae‐Hoon Lee Hitoshi Yamamoto Chang‐Hyeon An Sang‐Hyun Kim Seo‐Young An Jae‐Young Kim 《Journal of periodontal research》2019,54(5):533-545
995.
Carol B. Ware Angelique M. Nelson Brigham Mecham Jennifer Hesson Wenyu Zhou Erica C. Jonlin Antonio J. Jimenez-Caliani Xinxian Deng Christopher Cavanaugh Savannah Cook Paul J. Tesar Jeffrey Okada Lilyana Margaretha Henrik Sperber Michael Choi C. Anthony Blau Piper M. Treuting R. David Hawkins Vincenzo Cirulli Hannele Ruohola-Baker 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(12):4484-4489
The naïve pluripotent state has been shown in mice to lead to broad and more robust developmental potential relative to primed mouse epiblast cells. The human naïve ES cell state has eluded derivation without the use of transgenes, and forced expression of OCT4, KLF4, and KLF2 allows maintenance of human cells in a naïve state [Hanna J, et al. (2010) Proc Natl Acad Sci USA 107(20):9222–9227]. We describe two routes to generate nontransgenic naïve human ES cells (hESCs). The first is by reverse toggling of preexisting primed hESC lines by preculture in the histone deacetylase inhibitors butyrate and suberoylanilide hydroxamic acid, followed by culture in MEK/ERK and GSK3 inhibitors (2i) with FGF2. The second route is by direct derivation from a human embryo in 2i with FGF2. We show that human naïve cells meet mouse criteria for the naïve state by growth characteristics, antibody labeling profile, gene expression, X-inactivation profile, mitochondrial morphology, microRNA profile and development in the context of teratomas. hESCs can exist in a naïve state without the need for transgenes. Direct derivation is an elusive, but attainable, process, leading to cells at the earliest stage of in vitro pluripotency described for humans. Reverse toggling of primed cells to naïve is efficient and reproducible.It has become clear with the derivation of mouse epiblast stem cells (mEpiSCs) that pluripotency encompasses more than one stage of development (1, 2). The earlier “naïve” stage represents the preimplantation inner cell mass, typified by mouse ES cells (mESCs), and the “primed,” the postimplantation epiblast, typified by mEpiSCs and human ES cells (hESCs). The challenge in naïve cell maintenance has been protecting cells from differentiation stimuli. This has been achieved in mESCs through exposure to leukemia inhibitory factor (LIF), whereas addition of extracellular signal-regulated kinase (MEK) and glycogen synthase kinase 3 (GSK3) inhibitors (2i) in defined medium allows the cells to attain a homogeneous ground state (3). Defining characteristics of the naïve/ground vs. primed states are shown in Fig. S1A. In humans, the naïve stage has been difficult to capture as a stable in vitro state.There are practical advantages that come with a human naïve state. Among them is ease of trypsin passage and developmental capacity. Whole animals can be generated from good naïve mESCs through tetraploid complementation (4), and mEpiSCs cannot contribute to chimerism. Being more comparable to mESCs, naïve hESCs will likely allow increased developmental potential and a more accurate correlation to mESC data.It has been reported that human induced pluripotent cells (h-iPSCs) can be maintained in the naïve state if the pluripotency-inducing transgenes are not silenced (5). Only recently have hESCs been maintained in a naïve state without transgenes (6). Our primary aim was to generate naïve hESCs not dependent upon transgenes for stable culture. We toggled existing human ESC and mouse mEpiSC lines back from the primed state to grow under the influence of 2i without the need for Activin A. This helped us to define appropriate culture conditions for human naïve cells and allowed the de novo derivation of a naïve hESC line, Elf1. We report on the naïve state of human ESCs capable of unlimited culture in 2i. 相似文献
996.
Solid polymer electrolytes (SPEs) for Li-metal polymer batteries are prepared, in which poly(ethylene oxide) (PEO), lithium bis(trifluoromethylsulfonyl)imide (LiTFSI), and copper-oxide fillers are formulated. Their structural and electrochemical properties are analyzed when the morphology of the copper-oxide fillers has been modulated to spherical or dendritic structure. The ionic conductivity obtained by electrochemical impedance spectroscopy (EIS) has been increased to 1.007 × 10−4 S cm−1 at 30 °C and 1.368 × 10−3 S cm−1 at 60 °C, as the 5 wt% dendritic fillers have been added to the SPEs. This ionic conductivity value is 1.3 times higher than that of 5 wt% spherical filler-contained SPEs. The analyses of differential scanning calorimetry (DSC) and X-ray diffraction (XRD) indicate that the increase of ionic conductivity is due to the remarkable decrease of crystallinity upon the addition of copper-oxide filler into PEO matrix of SPEs. The fabricated SPEs with the dendritic copper-oxide fillers present a total ionic transference number of 0.99 and a lithium-ion transference number of 0.38. More importantly, it presents a stable potential window of 2.0–4.8 V at 25 °C and high thermal stability up to 300 °C. The specific discharge capacity of the prepared cell with the dendritic filler-contained SPEs is measured to be 51 mA h g−1 and 125 mA h g−1 under 0.1 current-rate (C-rate) at 25 °C and 60 °C, respectively. In this study, the ionic conductivity and the electrochemical performance of the PEO-based polymer electrolyte have been evaluated when morphologically different copper-oxide fillers have been incorporated into the PEO matrix. We have also confirmed the safety and the flexibility of the prepared solid polymer electrolytes when they are used in flexible lithium-metal polymer batteries (LMPBs).Solid polymer electrolytes (SPEs) for Li-metal polymer batteries are prepared, in which poly(ethylene oxide) (PEO), lithium bis(trifluoromethylsulfonyl)imide (LiTFSI), and copper-oxide fillers are formulated. 相似文献
997.
998.
Pyoeng Gyun Choe Hyung Jin Choi Nak-Hyun Kim Wan Beom Park Kyoung-Ho Song Ji Hwan Bang Eu Suk Kim Sang Won Park Hong Bin Kim Myoung-don Oh Nam Joong Kim 《Journal of the International AIDS Society》2014,17(1)
Introduction
Low bone mass is prevalent in HIV-positive patients. However, compared to Western countries, less is known about HIV-associated osteopenia in Asian populations.Methods
We performed a cross-sectional survey in Seoul National University Hospital from December 2011 to May 2012. We measured bone mineral density using central dual energy X-ray absorptiometry, with consent, in male HIV-positive patients, aged 40 years and older. Diagnosis of low bone mass was made using International Society for Clinical Densitometry Z-score criteria in the 40–49 years age group and World Health Organization T-score criteria in the >50-year age group. The data were compared with those of a community-based cohort in Korea.Results
Eighty-four HIV-positive male patients were included in this study. Median age was 49 (interquartile range [IQR], 45–56) years, and median body mass index (BMI) was 22.6 (IQR, 20.9–24.4). Viral suppression was achieved in 75 (89.3%) patients and median duration of antiretroviral therapy was 71 (IQR, 36–120) months. The overall prevalence of low bone mass was 16.7% in the 40–49 years age group and 54.8% in the>50 years age group. Our cohort had significantly lower bone mass at the femur neck and total hip than HIV-negative Koreans in the 40–49 years age group. Low bone mass was significantly associated with low BMI, and a high level of serum carboxy-terminal collagen crosslinks, but was not associated with antiretroviral regimen or duration of antiretroviral therapy.Conclusions
Low bone mass is prevalent in Korean HIV-positive males undergoing antiretroviral therapy, and may be associated with increased bone resorption. 相似文献999.
Jin-Young Park Kyung-Soo Oh Seung-Chul Bahng Seok-Won Chung Jin-Ho Choi 《Clinics in Orthopedic Surgery》2014,6(2):190-195
Background
Several studies have reported the clinical outcomes of medial ulnar collateral ligament (MUCL) reconstruction of the elbow joint in throwing athletes, including the rate of return to sports. However, little has been known about the imaging outcomes after MUCL reconstruction. The aim of this study is to report the clinical and imaging outcomes after MUCL reconstruction using figure of eight fashion in the elite and professional baseball players.Methods
This study included 17 baseball players, who underwent MUCL reconstruction between July 2007 and May 2010. The average follow-up period was 48.6 months. Imaging assessment consisted of preoperative plain and stress radiographs, magnetic resonance imaging, and postoperative serial ultrasonography. The clinical assessments were composed of visual analogue scale (VAS) for pain, range of motion, and the Conway scale.Results
The mean VAS score was 6.4 (range, 3 to 8) preoperatively and 2.2 (range, 0 to 4) postoperatively (p < 0.05). There were nine players (53%) classified as excellent who returned to sports at the same or higher level compared to preinjury. Serial ultrasonography revealed well-maintained grafts at 3 and 12 months in all of the players. Five out of 17 players showed decreased echogenecity in the common flexor tendon at 3 months, which was considered as remaining tissue swelling and resolved completely at 12 months.Conclusions
All grafts are well-maintained until 12-months based on the ultrasonographic findings, although only 53% of the players returned to preinjury level. 相似文献1000.
Young Choi Jae Man Kwak So Hak Chung Gu Hee Jung Jae Do Kim 《Clinics in Orthopedic Surgery》2014,6(1):72-79