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Fa‐Po Chung Ying‐Chieh Liao Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo Yu‐Feng Hu Ta‐Chuan Tuan Tze‐Fan Chao Jo‐Nan Liao Chin‐Yu Lin Ting‐Yung Chang Jennifer Jeanne B. Vicera Chye‐Gen Chin Cheng‐I Wu Chih‐Min Liu Po‐Tseng Lee Ting‐Chun Huang Isaiah C. Lugtu Shih‐Ann Chen 《Journal of cardiovascular electrophysiology》2020,31(1):9-17
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Jennifer Jeanne B. Vicera Yenn‐Jiang Lin Po‐Tseng Lee Shih‐Lin Chang Li‐Wei Lo Yu‐Feng Hu Fa‐Po Chung Chin‐Yu Lin Ting‐Yung Chang Ta‐Chuan Tuan Tze‐Fan Chao Jo‐Nan Liao Cheng‐I Wu Chih‐Min Liu Chung‐Hsing Lin Chieh‐Mao Chuang Chun‐Chao Chen Chye Gen Chin Shin‐Huei Liu Wen‐Han Cheng Le Phat Tai Sung‐Hao Huang Ching‐Yao Chou Isaiah Lugtu Ching‐Han Liu Shih‐Ann Chen 《Journal of cardiovascular electrophysiology》2020,31(6):1436-1447
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The predictors of successful percutaneous coronary intervention in ostial left anterior descending artery chronic total occlusion 下载免费PDF全文
Wei‐Chieh Lee MD Yu‐Sheng Lin MD Cheng‐I Cheng MD Chien‐Jen Chen MD Cheng‐Hsu Yang MD Hon‐Kan Yip MD Chi‐Ling Hang MD Chih‐Yuan Fang MD Chiung‐Jen Wu MD 《Catheterization and cardiovascular interventions》2014,84(4):E30-E37
Background: Percutaneous coronary intervention (PCI) to chronic total occlusion (CTO) has become one of the treatment strategies in recent era. The ostium of the left anterior descending artery (LAD) is one of the most difficult positions for CTO revascularization. Until now, limited data has been made available for the prediction of successful ostial LAD CTO PCI. Objective: The aim of the study was to compare the differences between ostial LAD and all other CTOs and to identify the predictors of successful ostial LAD CTO PCI. Methods: This retrospective analysis included consecutive patients referred for CTO PCI between January 2001 and September 2013. Ostial LAD CTO was defined as CTO at the position whose distance between lesion and left main bifurcation was less than 1 mm. Baseline demographics, lesion characteristics, interventional procedure details, and devices were compared between the ostial LAD group and the all other CTOs group. The predictors of successful ostial LAD CTO PCI were also evaluated. Results: 621 patients who underwent CTO PCI were enrolled retrospectively to this study. A total of 70 patients of ostial LAD CTO were compared with 551 patients of all other CTOs group in this study. Ostial LAD CTO was found to have more bridging and better collaterals than all other CTOs. Procedure time, fluoroscopic time, contrast volumes, the use of contralateral injection, and the use of the retrograde approach were significantly greater in the ostial LAD CTO group. The ostial LAD CTO group also had significantly higher J‐CTO scores (2.7 ± 0.8 vs. 2.2 ± 1.1, P = 0.011) and higher Syntax Scores (28.3 ± 6.5 vs. 20.9 ± 9.7, P < 0.001). A slightly lower final success rate, but statistically non‐significant, was observed in the ostial LAD CTO group (80.0% vs. 81.9%, P = 0.706). Univariate and multivariate logistic regression revealed that without antegrade failure and with retrograde success were predictors of the success of ostial LAD CTO PCI. Syntax Score was also capable of predicting the ostial LAD CTO PCI outcome. J‐CTO score was not found to be associated with final success for ostial LAD CTO patients. Conclusions: Ostial LAD CTO resulted in higher lesion complexity in J‐CTO scores and Syntax Scores. Ostial LAD CTO PCI had a slightly lower final success rate than that of all other CTOs PCI with longer procedure duration, fluoroscopic time and larger contrast volume. Without antegrade failure, with retrograde success, and lower Syntax Score were found to predict the success of ostial LAD CTO PCI. © 2014 Wiley Periodicals, Inc. 相似文献
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ChiaPin Lin YingChang Tung FuChih Hsiao ChiaHung Yang YiWei Kao YuSheng Lin YouChia Chu PaoHsien Chu 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(10):1846
Hypertension and dyslipidemia are important risk factors for cardiovascular disease. However, the clinical outcomes of fixed‐dose combination (FDC) versus free‐equivalent combination (FEC) of amlodipine and atorvastatin in the treatment of concurrent hypertension and dyslipidemia remain unknown. In this study, we included patients with newly diagnosed hypertension and dyslipidemia, without previously established cardiovascular disease, and treated with either FDC or FEC of amlodipine and atorvastatin were identified from the National Health Insurance Research Database of Taiwan and follow‐up for 5 years. By using 1:1 propensity score matching, a total of 1756 patients were enrolled in this study. The composite of major adverse cardiovascular events, including all‐cause mortality, myocardial infarction (MI), stroke, and coronary revascularization, occurred more frequently in the FEC group than in the FDC group (hazard ratio, 1.88; 95% confidence interval [CI], 1.42 to 2.5). Although the all‐cause mortality did not differ (hazard ratio, 0.46; 95% CI, 0.36 to 1.59), the FEC group developed increased MI, stroke, and coronary revascularization (hazard ratio, 2.87; 95% CI, 1.07 to 7.68; hazard ratio, 1.97; 95% CI, 1.41 to 2.74; and hazard ratio, 2.44; 95% CI, 1.26 to 4.69, respectively). Furthermore, as an unexpected result, a higher risk to develop new‐onset diabetes mellitus was observed with FEC regimens (hazard ratio, 2.19; 95% CI, 1.6 to 3.0). In conclusion, although the all‐cause mortality did not differ between the two groups, the FDC regimen of amlodipine and atorvastatin improved clinical outcomes when compared to FEC in patients with newly diagnosed hypertension and dyslipidemia. 相似文献
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Chih H. King Eric Lancaster Daniela Salomon Elior Peles Steven S. Scherer 《The Journal of comparative neurology》2014,522(14):3262-3280
The Kv7 (KCNQ) family of voltage‐gated K+ channels regulates cellular excitability. The functional role of Kv7.2 has been hampered by the lack of a viable Kcnq2‐null animal model. In this study, we generated homozygous Kcnq2‐null sensory neurons using the Cre‐Lox system; in these mice, Kv7.2 expression is absent in the peripheral sensory neurons, whereas the expression of other molecular components of nodes (including Kv7.3), paranodes, and juxtaparanodes is not altered. The conditional Kcnq2‐null animals exhibit normal motor performance but have increased thermal hyperalgesia and mechanical allodynia. Whole‐cell patch recording technique demonstrates that Kcnq2‐null sensory neurons have increased excitability and reduced spike frequency adaptation. Taken together, our results suggest that the loss of Kv7.2 activity increases the excitability of primary sensory neurons. J. Comp. Neurol. 522:3262–3280, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
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