全文获取类型
收费全文 | 9884篇 |
免费 | 590篇 |
国内免费 | 81篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 253篇 |
妇产科学 | 262篇 |
基础医学 | 1369篇 |
口腔科学 | 142篇 |
临床医学 | 766篇 |
内科学 | 2563篇 |
皮肤病学 | 122篇 |
神经病学 | 1435篇 |
特种医学 | 388篇 |
外科学 | 869篇 |
综合类 | 16篇 |
一般理论 | 3篇 |
预防医学 | 451篇 |
眼科学 | 129篇 |
药学 | 761篇 |
中国医学 | 10篇 |
肿瘤学 | 947篇 |
出版年
2024年 | 26篇 |
2023年 | 168篇 |
2022年 | 287篇 |
2021年 | 493篇 |
2020年 | 266篇 |
2019年 | 378篇 |
2018年 | 414篇 |
2017年 | 308篇 |
2016年 | 368篇 |
2015年 | 381篇 |
2014年 | 545篇 |
2013年 | 623篇 |
2012年 | 819篇 |
2011年 | 856篇 |
2010年 | 491篇 |
2009年 | 444篇 |
2008年 | 626篇 |
2007年 | 573篇 |
2006年 | 562篇 |
2005年 | 491篇 |
2004年 | 354篇 |
2003年 | 301篇 |
2002年 | 268篇 |
2001年 | 44篇 |
2000年 | 39篇 |
1999年 | 54篇 |
1998年 | 45篇 |
1997年 | 36篇 |
1996年 | 36篇 |
1995年 | 24篇 |
1994年 | 24篇 |
1993年 | 15篇 |
1992年 | 16篇 |
1991年 | 24篇 |
1990年 | 20篇 |
1989年 | 23篇 |
1988年 | 25篇 |
1987年 | 14篇 |
1986年 | 14篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 8篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1967年 | 2篇 |
1966年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
141.
142.
Antonio Piralla Ana Moreno Maria Ester Orlandi Elena Percivalle Chiara Chiapponi Fausto Vezzoli Fausto Baldanti the Influenza Surveillance Study Group 《Emerging infectious diseases》2015,21(7):1189-1191
Because swine influenza virus infection is seldom diagnosed in humans, its frequency might be underestimated. We report a immunocompromised hematologic patient with swine influenza A(H3N2) virus in 2014 in Italy. Local pigs were the source of this human infection. 相似文献
143.
Are 5‐HT3 antagonists effective in obsessive–compulsive disorder? A systematic review of literature 下载免费PDF全文
Daniele Serata Georgios D. Kotzalidis Chiara Rapinesi Delfina Janiri Simone Di Pietro Gemma Callovini Daria Piacentino Carlotta Gasperoni Roberto Brugnoli Vittoria Rachele Ferri Nicoletta Girardi Roberto Tatarelli Stefano Ferracuti Gloria Angeletti Paolo Girardi Antonio Del Casale 《Human psychopharmacology》2015,30(2):70-84
144.
Karen L Smith Rahul R Rao Clara Velázquez-Sánchez Marta Valenza Chiara Giuliano Barry J Everitt Valentina Sabino Pietro Cottone 《Neuropsychopharmacology》2015,40(5):1163-1171
Binge-eating disorder is characterized by excessive, uncontrollable consumption of palatable food within brief periods of time. The role of the glutamatergic N-methyl-D-aspartate (NMDA) receptor system in hedonic feeding is poorly understood. The aim of this study was to characterize the effects of the uncompetitive NMDA receptor antagonist memantine on palatable food-induced behavioral adaptations using a rat model, which mimics the characteristic symptomatology observed in binge-eating disorder. For this purpose, we allowed male Wistar rats to respond to obtain a highly palatable, sugary diet (Palatable group) or a regular chow diet (Chow control group), for 1 h a day, under a fixed-ratio 1 (FR1) schedule of reinforcement. Upon stabilization of food responding, we tested the effects of memantine on the Chow and Palatable food groups'' intake. Then, we tested the effects of memantine on food-seeking behavior, under a second-order schedule of reinforcement. Furthermore, we investigated the effects of memantine on the intake of food when it was offered in an aversive, bright compartment of a light/dark conflict test. Finally, we evaluated the effects of memantine on FR1 responding for food, when microinfused into the nucleus accumbens (NAcc) shell or core. Memantine dose-dependently decreased binge-like eating and fully blocked food-seeking behavior and compulsive eating, selectively in the Palatable food group. The drug treatment did not affect performance of the control Chow food group. Finally, intra-NAcc shell, but not core, microinfusion of memantine decreased binge-like eating. Together, these findings substantiate a role of memantine as a potential pharmacological treatment for binge-eating disorder. 相似文献
145.
146.
Valerio Rosato Antonio Ascione Riccardo Nevola Anna Ludovica Fracanzani Guido Piai Vincenzo Messina Ernesto Claar Carmine Coppola Luca Fontanella Rosa Lombardi Laura Staiano Giovanna Valente Maria Chiara Fascione Chiara Giorgione Annalisa Mazzocca Raffaele Galiero Pasquale Perillo Aldo Marrone Ferdinando Carlo Sasso Luigi Elio Adinolfi Luca Rinaldi 《Journal of viral hepatitis》2022,29(1):26-34
The long-term changes of liver stiffness (LS) in patients who achieve viral clearance after direct-acting anti-HCV therapy remain undefined. We conducted a multicentre prospective study to investigate this aspect. Patients with HCV infection treated with DAAs were enrolled from six Italian centres; they underwent clinical, biochemical, ultrasound and transient elastography evaluations before treatment (T0), 12 weeks (SVR12) and 24 months (T24) after the end of therapy. Among the 516 consecutive patients enrolled, 301 had cirrhosis. LS significantly decreased from T0 to SVR (14.3 vs 11.1 kPa, p = .002), with a progressive reduction until T24 (8.7 kPa, p < .001). However, only patients with steatosis and those who developed HCC did not experience a late improvement in LS. Multivariate analysis of baseline and follow-up variables identified steatosis as the only independent predictor of failure of LS improvement (OR 1.802, p = .013). ROC curve analysis of the association of LS with the risk of developing HCC showed that SVR12 ≥14.0 kPa had the highest accuracy (sensitivity 82%, specificity 99%; AUC: 0.774). Multivariate analysis revealed that LS was the only variable independently associated with an increased risk of developing HCC (OR 6.470, p = .035). Achieving an SVR was associated with a progressive, long-term decline of LS, suggesting a late improvement in liver fibrosis, besides the resolution of inflammation. Fatty liver and the development of HCC interfered with late reduction of LS. Patients with an LS ≥14 kPa at 12 weeks after the end of treatment were at higher risk for developing HCC. 相似文献
147.
148.
Mandoli Giulia Elena Borrelli Chiara Cameli Matteo Mondillo Sergio Ghiadoni Lorenzo Taddei Claudia Passino Claudio Emdin Michele Giannoni Alberto 《Heart failure reviews》2022,27(5):1869-1881
Heart Failure Reviews - Obstructive (OA) and central apneas (CA) are highly prevalent breathing disorders that have a negative impact on cardiac structure and function; while OA promote the... 相似文献
149.
Lucia Taramasso Paolo Bonfanti Elena Ricci Paolo Maggi Giancarlo Orofino Nicola Squillace Barbara Menzaghi Giordano Madeddu Chiara Molteni Francesca Vichi Erika Riguccini Annalisa Saracino Carmen Santoro Marta Guastavigna Daniela Francisci Antonio Di Biagio Giuseppe Vittorio De Socio 《HIV medicine》2022,23(1):70-79
150.
Laura Di Domenico Chiara E Sabbatini Giulia Pullano Daniel Lvy-Bruhl Vittoria Colizza 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2021,26(15)
Following the spread of the SARS-CoV-2 B.1.1.7 variant, social distancing was strengthened in France in January 2021. Using a two-strain mathematical model calibrated on genomic surveillance, we estimated that curfew measures allowed hospitalisations to plateau by decreasing transmission of the historical strains while B.1.1.7 continued to grow. School holidays appear to have further slowed down progression in February. Without progressively strengthened social distancing, a rapid surge of hospitalisations is expected, despite the foreseen increase in vaccination rhythm. 相似文献