全文获取类型
收费全文 | 1092篇 |
免费 | 66篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 18篇 |
妇产科学 | 13篇 |
基础医学 | 146篇 |
口腔科学 | 5篇 |
临床医学 | 121篇 |
内科学 | 199篇 |
皮肤病学 | 19篇 |
神经病学 | 123篇 |
特种医学 | 32篇 |
外科学 | 129篇 |
综合类 | 17篇 |
预防医学 | 120篇 |
眼科学 | 12篇 |
药学 | 78篇 |
中国医学 | 14篇 |
肿瘤学 | 109篇 |
出版年
2024年 | 2篇 |
2023年 | 10篇 |
2022年 | 20篇 |
2021年 | 38篇 |
2020年 | 20篇 |
2019年 | 38篇 |
2018年 | 42篇 |
2017年 | 40篇 |
2016年 | 33篇 |
2015年 | 36篇 |
2014年 | 44篇 |
2013年 | 37篇 |
2012年 | 94篇 |
2011年 | 88篇 |
2010年 | 44篇 |
2009年 | 40篇 |
2008年 | 84篇 |
2007年 | 105篇 |
2006年 | 71篇 |
2005年 | 51篇 |
2004年 | 58篇 |
2003年 | 41篇 |
2002年 | 46篇 |
2001年 | 6篇 |
2000年 | 6篇 |
1999年 | 6篇 |
1998年 | 12篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 7篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有1160条查询结果,搜索用时 15 毫秒
81.
McCormack FX Inoue Y Moss J Singer LG Strange C Nakata K Barker AF Chapman JT Brantly ML Stocks JM Brown KK Lynch JP Goldberg HJ Young LR Kinder BW Downey GP Sullivan EJ Colby TV McKay RT Cohen MM Korbee L Taveira-DaSilva AM Lee HS Krischer JP Trapnell BC;National Institutes of Health Rare Lung Diseases Consortium;MILES Trial Group 《The New England journal of medicine》2011,364(17):1595-1606
82.
Gross AR Goldsmith C Hoving JL Haines T Peloso P Aker P Santaguida P Myers C;Cervical Overview Group 《The Journal of rheumatology》2007,34(5):1083-1102
OBJECTIVE: To determine if conservative treatments (manual therapies, physical medicine methods, medication, and patient education) relieved pain or improved function/disability, patient satisfaction, and global perceived effect in adults with acute, subacute, and chronic mechanical neck disorders (MND) by updating 11 systematic reviews of randomized controlled trials (RCT). METHODS: Two independent authors selected studies, abstracted data, and assessed methodological quality from computerized databases. We calculated relative risks and standardized mean differences (SMD) when possible. In the absence of heterogeneity, we calculated pooled effect sizes. RESULTS: We studied 88 unique RCT. The mean methodological quality scores were acceptable in 59% of the trials. We noted strong evidence of benefit for maintained pain reduction [pooled SMD -0.85 (95% CI -1.20, -0.50)], improvement in function, and positive global perceived effect favoring exercise plus mobilization/manipulation versus control for subacute/chronic MND. We found moderate evidence of longterm benefit for improved function favoring direct neck strengthening and stretching for chronic MND, and for high global perceived effect favoring vertigo exercises. We noted moderate evidence of no benefit for botulinium-A injection [pooled SMD -0.39 (95% CI -01.25, 0.47)]. We found many treatments demonstrating short-term effects. CONCLUSION: Exercise combined with mobilization/manipulation, exercise alone, and intramuscular lidocaine for chronic MND; intravenous glucocorticoid for acute whiplash associated disorders; and low-level laser therapy demonstrated either intermediate or longterm benefits. Optimal dosage of effective techniques and prognostic indicators for responders to care should be explored in future research. 相似文献
83.
Kielar C Maddox L Bible E Pontikis CC Macauley SL Griffey MA Wong M Sands MS Cooper JD 《Neurobiology of disease》2007,25(1):150-162
Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1 deficient mice (Ppt1-/-) and the development of their seizure phenotype. Surprisingly, cortical atrophy and neuron loss occurred only late in disease progression but were preceded by localized astrocytosis within individual thalamic nuclei and the progressive loss of thalamic neurons that relay different sensory modalities to the cortex. This thalamic neuron loss occurred first within the visual system and only subsequently in auditory and somatosensory relay nuclei or the inhibitory reticular thalamic nucleus. The loss of granule neurons and GABAergic interneurons followed in each corresponding cortical region, before the onset of seizure activity. These findings provide novel evidence for successive neuron loss within the thalamus and cortex in Ppt1-/- mice, revealing the thalamus as an important early focus of INCL pathogenesis. 相似文献
84.
Kossoff EH Zupec-Kania BA Amark PE Ballaban-Gil KR Christina Bergqvist AG Blackford R Buchhalter JR Caraballo RH Helen Cross J Dahlin MG Donner EJ Klepper J Jehle RS Kim HD Christiana Liu YM Nation J Nordli DR Pfeifer HH Rho JM Stafstrom CE Thiele EA Turner Z Wirrell EC Wheless JW Veggiotti P Vining EP;Charlie Foundation Practice Committee of the Child Neurology Society;Practice Committee of the Child Neurology Society;International Ketogenic Diet Study Group 《Epilepsia》2009,50(2):304-317
85.
Jim A. Murray Farhat L. Khanim Rachel E. Hayden Charlie F. Craddock Tessa L. Holyoake Nick Jackson Matthew Lumley Chris M. Bunce Mark T. Drayson 《British journal of haematology》2010,149(1):65-69
Acute myeloid leukaemia (AML) causes life‐threatening deficits of functional blood cells that require management using red cell and platelet transfusion and aggressive treatment of neutropenic infections. Current cytotoxic chemotherapy further worsens the problem of reduced haemopoiesis and two‐thirds of patients are too frail to tolerate intensive chemotherapy at all. Median survival amongst these patients remains at <3 months emphasizing the urgent need for anti‐AML therapies that do not suppress haemopoiesis. Our laboratory studies showed combined Bezafibrate and Medroxyprogesterone acetate (BaP) had activity against AML without toxicity to normal stem cells. Here we report the safety and efficacy of BaP in 20 patients (19 AML, 1 high‐risk myelodysplasia) for whom intensive chemotherapy was not an option. No patient exhibited haematological toxicity from BaP. Eleven patients took BaP alone for >4 weeks. One reverted from high risk myelodysplasia and remains transfusion independent after 201 weeks of therapy. Three AML patients gained major haematological improvements for 22–30 weeks; in one, marrow was available to document a partial AML response. Thus, this trial indicates that BaP therapy has potential for treatment of elderly and relapsed AML. 相似文献
86.
Sefton JM Hicks-Little CA Hubbard TJ Clemens MG Yengo CM Koceja DM Cordova ML 《Archives of physical medicine and rehabilitation》2008,89(10):1991-1995
Sefton JM, Hicks-Little CA, Hubbard TJ, Clemens MG, Yengo CM, Koceja DM, Cordova ML. Segmental spinal reflex adaptations associated with chronic ankle instability.
Objective
To further understanding of the role that segmental spinal reflexes play in chronic ankle instability (CAI).Design
A 2 × 2 repeated-measures case-control factorial design. The independent variables were ankle group with 2 levels (healthy, CAI) and stance with 2 levels (single, double legged).Setting
University research laboratory.Participants
Twenty-two participants with CAI and 21 matched healthy controls volunteered.Interventions
Not applicable.Main Outcome Measures
The dependent variables were 2 measures of motoneuron pool excitability: paired reflex depression (PRD) and recurrent inhibition.Results
A 2 × 2 repeated-measures multivariate analysis of variance revealed a significant interaction between group and stance on the linear combination of PRD and recurrent inhibition variables (Wilks λ=.808, F2,40=4.77, P=.014). Follow-up univariate F tests revealed an interaction between group and stance on the PRD (F1,41=9.74, P=.003). Follow-up dependent t tests revealed a significant difference between single- and double-legged PRD in the healthy participants (t20=-3.76, P=.001) with no difference in CAI participants (t21=-0.44, P=.67). Finally, there was a significant difference in recurrent inhibition between healthy (mean, 83.66) and CAI (mean, 90.27) (P=.004).Conclusions
This study revealed that, compared with healthy participants, CAI participants were less able to modulate PRD when going from a double- to a single-legged stance. Additionally, CAI participants showed higher overall levels of recurrent inhibition when compared with healthy matched controls. 相似文献87.
ObjectiveResearchers have no empirically based search stopping rule when looking for potentially relevant articles for inclusion in systematic reviews. We tested a stopping strategy based on capture–mark–recapture (CMR; i.e., the Horizon Estimate) statistical modeling to estimate the total number of articles in the domain of clinical decision support tools for osteoporosis disease management using four large bibliographic databases (Medline, EMBASE, CINAHL, and EBM reviews).Study Design and SettingRetrospective evaluation of the Horizon Estimate using a systematic review of randomized controlled trials (RCTs) at two levels of article screening: title and abstract (1,246 potentially relevant articles) and full text (42 potentially relevant articles).ResultsThe CMR model suggests that the total number of potential articles was 1,838 for the first level of screening, and 49 for the full-text level. The four databases provided 68% of known articles for the first level of screening and 81% for full-text screening.ConclusionsThe CMR technique can be used in systematic reviews to estimate the closeness to capturing the total body of literature on a given topic. More studies are needed to objectively determine the usefulness of Horizon Estimates as a stopping rule strategy for systematic review searching. 相似文献
88.
89.
90.