复方丹参注射液过敏性不良反应84例文献分析

目的:探讨复方丹参注射液致过敏性不良反应的规律和特点。方法:检索1994-2008年国内公开发行的医药期刊,对复方丹参注射液致过敏性不良反应病例进行分析。结果:共检索到复方丹参注射液致过敏性不良反应病例84例,男性43例,女性41例,其中死亡3例;过敏性不良反应多发生在给药30min以内;病例中共54例年龄在50岁以上,占全部病例的64%。结论:复方丹参注射液可导致过敏性不良反应,多发生于50岁以上患者中,严重时危及生命,应引起临床高度重视。     

正交实验法优选陆英总黄酮的提取工艺

目的:筛选陆英总黄酮的最佳提取工艺。方法:采用正交实验法,以总黄酮含量为考察指标,比较不同乙醇浓度、溶剂用量及提取时间对提取效果的影响。结果:最佳提取工艺为:10倍量60%乙醇,回流提取3次,每次40min。结论:优选的陆英总黄酮提取工艺合理稳定,可为制定陆英的质量标准提供一定的实验依据。     

手术治疗儿童孟氏骨折的临床远期疗效观察

目的:观察手术治疗儿童孟氏骨折的远期疗效。方法:对1994年6月-2004年12月年我院收治的32例儿童孟氏骨折,实施手术治疗,术后随访。结果:术后随访时间3.5～14年,平均8.8年。其中优23例,良7例,差2例,优良率93.8%。结论:儿童孟氏骨折应积极尽早进行手术治疗,远期疗效满意。     

Expressions and their significance of PTTG and PC proteins in glioma

Objective： To investigate the expressions and their relationship of pituitary tumor transforming gene （PTTG） and proliferating cell nuclear antigen （PCNA） in glioma. Methods： The protein expressions of PTTG and PCNA were detected by immunostaining assay using streptavidin-peroxidase （SP） method in 80 cases of glioma. Results： The positive rates of PTTG in grades Ⅰ-Ⅳ gliomas were 56.3%, 68.2%, 80.8%, and 100.0% respectively, and the protein expression of PTTG increased with the increasing of the pathological grade （X^2= 9.602, P 〈 0.05）; The positive rates of PCNA protein were 37.5%, 54.5%, 69.2%, and 93.8% respectively, and the protein expression of PCNA increased with the increasing of the pathological grade （X2 = 12.147, P 〈 0.01）. The expression of PTTG had positive correlation with the expression of PCNA protein （~s = 0.557, P 〈 0.01）. Conclusion： The expressions of PTTG and PCNA proteins were related to malignant degree of glioma, and may cooperate with each other in the tumorigenesis and progression and can be considered as the indicators of the biological behaviors in glioma.     

Virtual Rhesus Labyrinth Model Predicts Responses to Electrical Stimulation Delivered by a Vestibular Prosthesis

Journal of the Association for Research in Otolaryngology - To better understand the spread of prosthetic current in the inner ear and to facilitate design of electrode arrays and stimulation...     

Effects of atrial natriuretic peptide on coronary vascular resistance in the intact awake dog

Atrial natriuretic peptide has been reported to cause vasoconstriction, vasodilation or no change of coronary vascular resistance in isolated perfused hearts or in open chest animal models. Because general anesthesia and acute surgical trauma may perturb baseline coronary hemodynamics and alter responses to experimental interventions, this study examined the effects of human atrial natriuretic peptide (arginine-102-tyrosine-126) and rat atriopeptin II (serine-103-arginine-125) on the coronary circulation of unsedated, awake dogs. Studies were performed in 12 chronically instrumented animals in which a surgically implanted electromagnetic flow probe and intracoronary catheter allowed measurement of left circumflex coronary blood flow during intraarterial administration of the atrial natriuretic peptides. Bolus doses of both human atrial natriuretic peptide and rat atriopeptin II produced dose-dependent coronary vasodilation; the threshold for coronary vasodilation was 0.2 micrograms/kg body weight for both agents. Coronary vasodilation produced by human atrial natriuretic peptide was not antagonized by adenosine receptor blockade or by cyclooxygenase inhibition with indomethacin. Thus, atrial natriuretic peptides produced dose-dependent coronary vasodilation in intact awake dogs that was not dependent on adenosine-mediated or prostaglandin-mediated mechanisms.     

A refined surgical treatment modality for bromhidrosis: Subcutaneous scissor with micropore

Axillary bromhidrosis has a strong negative effect on one's social life. A high success rate and few complications are criteria for a surgical treatment. The objective of this study was to evaluate a new surgical treatment modality for bromhidrosis: subcutaneous scissor with micropore. Twenty patients with bromhidrosis were treated. Patients were placed in a supine position with their treated arms abducted to 110°. After injection of 60 mL of tumescent solution into each axilla, one small incision was made at the middle axillary of the hair‐bearing area. The whole hair‐bearing skin was undermined at the level of the superficial fat to obtain adequate skin eversion. The flaps were everted to offer full exposure of the apocrine glands, and meticulous excision of each gland was performed. Both sides were punctured with scalpel. The micropore was used for drainage, and whose width was just 3 mm. Finally, the incisions were re‐approximated, and bulky compressive dressings were applied to the area for 72 hours. Of the 40 axillae (20 patients), 34 (85.0%) showed excellent results, and six (15.0%) had good results. Malodor was significantly decreased. There were no serious complications. This technique can produce excellent results with a lower complication rate than most other surgical modalities and can be performed without costly equipment.