全文获取类型
收费全文 | 5081篇 |
免费 | 310篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 70篇 |
儿科学 | 92篇 |
妇产科学 | 125篇 |
基础医学 | 787篇 |
口腔科学 | 224篇 |
临床医学 | 533篇 |
内科学 | 1021篇 |
皮肤病学 | 83篇 |
神经病学 | 327篇 |
特种医学 | 504篇 |
外科学 | 508篇 |
综合类 | 128篇 |
一般理论 | 1篇 |
预防医学 | 298篇 |
眼科学 | 45篇 |
药学 | 332篇 |
中国医学 | 53篇 |
肿瘤学 | 335篇 |
出版年
2023年 | 22篇 |
2022年 | 90篇 |
2021年 | 160篇 |
2020年 | 70篇 |
2019年 | 109篇 |
2018年 | 130篇 |
2017年 | 99篇 |
2016年 | 146篇 |
2015年 | 188篇 |
2014年 | 234篇 |
2013年 | 270篇 |
2012年 | 422篇 |
2011年 | 357篇 |
2010年 | 208篇 |
2009年 | 177篇 |
2008年 | 260篇 |
2007年 | 259篇 |
2006年 | 253篇 |
2005年 | 208篇 |
2004年 | 152篇 |
2003年 | 156篇 |
2002年 | 147篇 |
2001年 | 118篇 |
2000年 | 128篇 |
1999年 | 75篇 |
1998年 | 66篇 |
1997年 | 64篇 |
1996年 | 59篇 |
1995年 | 44篇 |
1994年 | 36篇 |
1993年 | 40篇 |
1992年 | 49篇 |
1991年 | 46篇 |
1990年 | 40篇 |
1989年 | 47篇 |
1988年 | 50篇 |
1987年 | 78篇 |
1986年 | 58篇 |
1985年 | 24篇 |
1984年 | 20篇 |
1983年 | 31篇 |
1982年 | 23篇 |
1981年 | 31篇 |
1980年 | 23篇 |
1979年 | 19篇 |
1978年 | 18篇 |
1976年 | 26篇 |
1975年 | 14篇 |
1974年 | 14篇 |
1972年 | 16篇 |
排序方式: 共有5466条查询结果,搜索用时 0 毫秒
91.
92.
Anthony J. Bonito Costica Aloman M. Isabel Fiel Nichole M. Danzl Sungwon Cha Erica G. Weinstein Seihwan Jeong Yongwon Choi Matthew C. Walsh Konstantina Alexandropoulos 《The Journal of clinical investigation》2013,123(8):3510-3524
TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development. mTECs regulate T cell tolerance by ectopically expressing self-antigens and eliminating autoreactive T cells in the thymus. Here we show that mice with mTEC depletion due to conditional deletion of Traf6 expression in murine thymic epithelial cells (Traf6ΔTEC mice) showed a surprisingly narrow spectrum of autoimmunity affecting the liver. The liver inflammation in Traf6ΔTEC mice exhibited all the histological and immunological characteristics of human autoimmune hepatitis (AIH). The role of T cells in AIH establishment was supported by intrahepatic T cell population changes and AIH development after transfer of liver T cells into immunodeficient mice. Despite a 50% reduction in natural Treg thymic output, peripheral tolerance in Traf6ΔTEC mice was normal, whereas compensatory T regulatory mechanisms were evident in the liver of these animals. These data indicate that mTECs exert a cell-autonomous role in central T cell tolerance and organ-specific autoimmunity, but play a redundant role in peripheral tolerance. These findings also demonstrate that Traf6ΔTEC mice are a relevant model with which to study the pathophysiology of AIH, as well as autoantigen-specific T cell responses and regulatory mechanisms underlying this disease. 相似文献
93.
94.
Cha SH Wolfgang M Tokutake Y Chohnan S Lane MD 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(44):16871-16875
The American diet, especially that of adolescents, contains highly palatable foods of high-energy content and large amounts of high-fructose sweeteners. These factors are believed to contribute to the obesity epidemic and insulin resistance. Previous investigations revealed that the central metabolism of glucose suppresses food intake mediated by the hypothalamic AMP-kinase/malonyl–CoA signaling system. Unlike glucose, centrally administered fructose increases food intake. Evidence presented herein indicates that the more rapid initial steps of central fructose metabolism deplete hypothalamic ATP level, whereas the slower regulated steps of glucose metabolism elevate hypothalamic ATP level. Consistent with effects on the [ATP]/[AMP] ratio, fructose increases phosphorylation/activation of hypothalamic AMP kinase causing phosphorylation/inactivation of acetyl–CoA carboxylase, whereas glucose has the inverse effects. The changes provoked by central fructose administration reduce hypothalamic malonyl–CoA level and thereby increase food intake. These findings explain the paradoxical fructose effect on food intake and lend credence to the malonyl–CoA hypothesis. 相似文献
95.
Effect of Granulocyte Colony-Stimulating Factor on Chemotherapeutic Activity of Cytosine Arabinoside in Acute Leukemic Cell Lines 总被引:1,自引:0,他引:1
Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 micromol/L) and/or 5 ng/mL G-CSE G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on myeloid cell lines (HL-60 and KG-1). 相似文献
96.
Kwon HS Cho JH Kim HS Lee JH Song BR Oh JA Han JH Kim HS Cha BY Lee KW Son HY Kang SK Lee WC Yoon KH 《Diabetes research and clinical practice》2004,66(Z1):S133-S137
We developed a blood glucose management system using the Internet and short message service (SMS) which can lessen the social economic burden and materialize an individualized diabetes mellitus management. A total of 185 diabetic patients participated in this study and their mean age was 42.4 years old (8-79 year-old). Participants sent their self-measured blood glucose levels, medication and its dosages, amount of meal, and degree of exercise to their health providers in this specialized web-based diabetes management system for 3 months. The health providers consisting of endocrinology specialists, dietitians, and nurses sent recommendations for individualized diabetes management according to the data on the web. Laboratory tests including lipid profiles and glycated hemoglobin (HbA1c), and a survey of satisfaction about this system were performed before and after the study period. The mean HbA1c improved from 7.5 +/- 1.5 to 7.0 +/- 1.1% after using the management program (P = 0.003). The mean serum triglyceride and HDL-cholesterol levels turned for the better also. HbA1c improved from 8.4 +/- 1.2 to 7.5 +/- 1.0% after applying this program to patients with the HbA1c of 7% or higher at baseline (P = 0.010). We propose this web-based diabetic patient management system as a new tool for communication between health care providers and patients. 相似文献
97.
98.
Although gastrointestinal diseases are reported at various times throughout the year, some particular seasons are associated with a higher incidence of these diseases. This study aimed to identify the seasonal variations of peptic ulcer (PU), peptic ulcer bleeding (PUB), and acute pancreatitis (AP) in South Korea.We conducted a retrospective, observational cohort study of all subjects aged >18 years between 2012 and 2016 using the Health Insurance Review and Assessment-National Patient Samples database, previously converted to the standardized Observational Medical Outcomes Partnership-Common Data Model. We assessed the overall seasonal variations of PU, PUB, and AP and further analyzed seasonal variations according to age and sex subgroups.In total, 14,626 patients with PU, 3575 with PUB, and 9023 with AP were analyzed for 5 years. A clear seasonal variation was noted in PU, with the highest incidence rate during winter, the second highest during spring, the third highest during summer, and the lowest incidence during autumn for 5 years (P < .001). PUB also showed significant seasonal fluctuations, with winter peak for 4 years, except 1 year, which had a spring peak (P < .001). However, AP showed no clear seasonal variations (P = .090). No significant differences in the seasonal variation of PU, PUB, and AP were observed according to sex and age subgroups (<60 years vs ≥60 years).Seasonal variation of PU and PUB should be considered when determining allocation of available health care resources. 相似文献
99.
Lee Seulkee Kang Seonyoung Eun Yeonghee Kim Hyungjin Lee Jaejoon Koh Eun-Mi Kim Duk-Kyung Cha Hoon-Suk 《Clinical rheumatology》2022,41(6):1769-1777
Clinical Rheumatology - To describe the clinical characteristics and radiographic outcomes of vascular Behçet’s disease (BD) involving the aorta or its major branches. This retrospective... 相似文献
100.
Insulin‐like growth factor‐1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression
下载免费PDF全文
![点击此处可从《International journal of experimental pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Young Wha Koh Dok Hyun Yoon Cheolwon Suh Hee Jeong Cha Jooryung Huh 《International journal of experimental pathology》2015,96(4):232-239
The purpose of this study was to examine the prognostic significance of insulin‐like growth factor‐1 receptor (IGF‐1R) expression alone and in relation to the expression of the MET‐ receptor and the MET‐homologous receptor RON, in classical Hodgkin's lymphoma (cHL). Tumour samples from patients with cHL (n = 202; median age 37.5 years) were analysed retrospectively for IGF‐R1, MET or RON expression by immunohistochemistry using tissue microarrays. The median follow‐up time was 3.7 years (range, 0.1–20 years). Twenty‐nine patients (14.3%) expressed IGF‐1R protein in Hodgkin/Reed–Sternberg (HRS) cells, which was associated with a better overall survival (OS) (P = 0.036). IGF‐1R expression was closely associated with MET receptor expression and low level of lactate dehydrogenase. In patients with cHL receiving doxorubicin, bleomycin, vinblastine and dacarbazine, those expressing IGF‐1R showed a trend towards better OS and event‐free survival than IGF‐1R‐negative patients (P = 0.129 and P = 0.115 respectively), but statistical significance was not reached. This study suggests that IGF‐1R expression could be associated with better clinical outcome in cHL but is significantly associated with the expression of MET receptor. 相似文献