Diagnostic value of stereotactic biopsy of cerebral lesions in patients with AIDS

Summary A neurological complication occurs in 40–60% of HIV infected patients during the course of the disease. In 10–20% the neurological complication is the first manifestation of the HIV infection. A reliable neuropathological diagnosis is a prerequisite for a specifically selected treatment. While modern computer-assisted imaging techniques, such as computed tomography or magnetic resonance imaging, do possess a high sensitivity, they do not as a rule permit an unambiguous diagnosis.Between October 1989 and July 1994 we biopsied 38 HIV infected patients stereotactically. The indication for the biopsy was determined by having radiologically detectable lesions with no regression tendency in patients under antitoxoplasmosis therapy. In 89% an unambiguous diagnosis wa made based on the biopsy; 11 % of the biopsies were not diagnostic. For the most part, toxoplasmosis (31%) and progressive multifocal leucoencephalopathy (29%) were involved. 18% of the patients suffered from a non-Hodgkin lymphoma. The foci were primarily frontal (47%), parietal (21%) or localised in the basal ganglia area (11%). The result of the biopsy led to a change in treatment for 52% of the patients. Morbidity and mortality of the operation were 0%.The results or our research series are similar to other groups. It was shown that stereotactic brain biopsy is a safe and effective method for establishing a sound basis for treating the frequently life-threatening cerebral complications of AIDS.     

Le rôle des représentations de la maladie et de la douleur dans la relation patient-thérapeute

Résumé  La rencontre entre patient et thérapeute dans la relation de soins met en présence non seulement deux individus, mais aussi deux systèmes de pensée. Elle suppose donc l'articulation de deux types de savoirs, profane d'une part et scientifique d'autre part. La clarification et la prise en compte des représentations du patient à propos de l'atteinte dont il souffre constitue un enjeu important de la relation. Il en va de même des attentes du thérapeute par rapport à ce qu'il considère comme un comportement douloureux adéquat, par exemple. Faute de la prise en compte des modèles de référence explicites et implicites tant du patient que du thérapeute, la relation peut déboucher sur des malentendus, des réactions d'agressivité, d'anxiété, et conduire à une rupture de cette relation.

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Summary  The patient-therapist relationship involves not only two individuals, but also two systems of thinking. It calls forth lay knowledge on the one hand and scientific knowledge on the other hand. The patient's representations about his pain and suffering may play an important role in the patient-health care provider relationship and thus need to be clarified and taken into account. This need also holds true where the therapist's expectations are concerned, for example with regard to what is considered as an adequate pain behavior. Failing to take into account the explicit and implicit models of both the patient and the therapist may lead to misunderstandings, aggressive behaviors, anxious reactions, and thus hamper or even disrupt the patient-therapist relationship.

     

Complications of treatment of urethral stricture in our practice

Bleeding is the most common early postoperative complication of the treatment of urethral stricture, while recurrent stricture is the most common late postoperative complication irrespective of the method of treatment applied. The different sophisticated methods of urethroplasty make it possible today to treat successfully complicated urethral strictures. The results of such treatment, however, have been associated with a variety of complications (impotence, incontinence and urethrocutaneous fistula), especially when simple methods such as bouginage are used. Although bouginage is associated with a greater recurrence rate of urethral stricture than is urethroplasty, the former should be encouraged in centres where facilities and trained urologists are limited, as it often occurs in the developing countries, since the method is simple and can be used as emergency without prior urethrogram.     

Split tolerance in chimeric GVH mice

Abstract The i.v. inoculation of parental spleen cells into unirradiated adult F1 hybrid mice results in a graft-versus-host reaction (GVHR). In the strain combination B10D2±(B10.BRx B10.D2) F1, this reaction is associated with thymic injury and transient but profound cellular immune deficiency. We further analysed the immune status of these mice 60 days after GVHR induction. Phenotypic studies of spleen cells showed that these mice were re-populated with parental lymphocytes resulting in a high degree of chimerism (85%). At this time, the mice looked healthy and recovered a normal cytotoxic T cell response (CTL) against allogeneic cells. GVH chimeric splenocytes were unresponsive against F 1 hybrid cells in mixed lymphocyte culture (MLC), but exhibited anti-F1 CTL reactivity. We also analysed the anti-F 1 reactivity of these mice in vivo. GVH chimeric splenocytes were unable to induce GVHR after injection into a new F1 hybrid and F1 GVH mice specifically rejected F1 bone marrow (BM) cells after lethal irradiation. Grafting a neonatal parental thymus prevented the rejection of F1 BM cells and restored CTL alloreactivity. It is concluded that the chimeric state induced by GVHR is associated with a split tolerance and that a radiosensitive thymic-dependent mechanism is involved in maintaining self-tolerance in these mice.     

Rolle der Winkelstabilität bei der intramedullären Stabilisierung

Zusammenfassung Winkelstabile Plattenfixateur-interne-Systeme haben in den letzten 20 Jahren zunehmend an Bedeutung gewonnen. Die aus der Winkelstabilität resultierende flächenhafte Krafteinleitung und gleichmäßigere Kraftverteilung führen zu einer besseren Knochenbruchheilung insbesondere im metaphysischen Bereich und bei Osteoporose. Bei Marknagelsystemen ist die Winkelstabilität bislang nur partiell verwirklicht. Der vorgestellte winkelstabile Tibiamarknagel realisiert an jedem einzelnen Bolzen eine Winkelstabilität mit dem einliegenden intramedullären Kraftträger. Von Februar 2002–August 2004 wurden 21 Patienten mit ihm behandelt. In 13 Fällen wurden Frakturen stabilisiert, 6 Patienten hatten Fehlstellungen, 2 Patienten Pseudarthrosen. Zum Nachuntersuchungszeitpunkt waren alle Behandlungen abgeschlossen. Postoperative Komplikationen traten nicht auf. In allen Fällen wurde eine vollständige Durchbauung erreicht. In 6 Fällen fand sich radiologisch eine verzögerte Knochenbruchheilung. Die ersten klinischen Erfahrungen mit dem winkelstabilen Tibiamarknagel zeigen, dass dieser aufgrund der höheren Primärstabilität insbesondere im metaphysären Knochenbereich mit kurzen Fragmenten sowie bei Osteoporose Vorteile gegenüber anderen nichtwinkelstabilen oder nur partiell winkelstabilen Marknagelsystemen erbringt. Die verzögerten Knochenbruchheilungen bedürfen weiterer klinischer und biomechanischer Untersuchungen.