全文获取类型
收费全文 | 787篇 |
免费 | 39篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 89篇 |
妇产科学 | 62篇 |
基础医学 | 69篇 |
口腔科学 | 21篇 |
临床医学 | 67篇 |
内科学 | 167篇 |
皮肤病学 | 24篇 |
神经病学 | 50篇 |
特种医学 | 64篇 |
外科学 | 130篇 |
综合类 | 7篇 |
预防医学 | 12篇 |
眼科学 | 32篇 |
药学 | 14篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 7篇 |
2022年 | 8篇 |
2021年 | 16篇 |
2020年 | 12篇 |
2019年 | 14篇 |
2018年 | 18篇 |
2017年 | 13篇 |
2016年 | 28篇 |
2015年 | 19篇 |
2014年 | 27篇 |
2013年 | 32篇 |
2012年 | 46篇 |
2011年 | 55篇 |
2010年 | 30篇 |
2009年 | 41篇 |
2008年 | 76篇 |
2007年 | 64篇 |
2006年 | 45篇 |
2005年 | 45篇 |
2004年 | 58篇 |
2003年 | 35篇 |
2002年 | 39篇 |
2001年 | 23篇 |
2000年 | 12篇 |
1999年 | 22篇 |
1998年 | 3篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1989年 | 2篇 |
1987年 | 2篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1973年 | 3篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 3篇 |
排序方式: 共有827条查询结果,搜索用时 390 毫秒
81.
Celik Y Kilinçer C Hamamcioğlu MK Balci K Birgili B Cobanoğlu S Utku U 《Turkish neurosurgery》2008,18(1):82-84
Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant nerve disease usually caused by 1,5 Mb deletion on chromosome 17p11.2.2-p12, the region where the PMP-22 gene is located. The patients with HNPP usually have relapsing and remitting entrapment neuropathies due to compression. We present a 14-year-old male who had acute onset, right-sided ulnar nerve entrapment at the elbow. He had electrophysiological findings of bilateral ulnar nerve entrapments (more severe at the right side) at the elbow and bilateral median nerve entrapment at the wrist. Genetic tests of the patient demonstrated deletions in the 17p11.2 region. The patient underwent decompressive surgery for ulnar nerve entrapment at the elbow and completely recovered two months after the event. Although HNPP is extremely rare, it should be taken into consideration in young adults with entrapment neuropathies. 相似文献
82.
Role of novel biomarkers of inflammation in patients with stable coronary heart disease 总被引:3,自引:0,他引:3
Atherosclerosis is a dynamic chronic inflammatory process, and some inflammatory biomarkers have roles in this process. The levels of C-reactive protein (CRP) in patients with chronic stable coronary heart disease (CHD) have not been investigated well, and the levels of macrophage colony-stimulating factor (M-CSF) and interleukin-3 (IL-3) in patients with chronic stable CHD and the effects of these cytokines on atherogenesis are not known. To determine whether new inflammatory biomarkers have roles in atherosclerosis, the authors measured the levels of CRP, M-CSF, and IL-3 in patients with chronic stable CHD and in healthy controls. They measured plasma CRP concentrations by using a highly sensitive CRP reagent with immunonephelometric method, and plasma M-CSF and IL-3 concentrations with the help of a commercial enzyme-linked immunoassay test in 31 patients with chronic stable CHD documented by coronary angiography and in 22 age-matched healthy control subjects documented by coronary angiography. Mean plasma CRP, M-CSF, and IL-3 concentrations in patients with chronic stable CHD were significantly higher than those in controls (8.2 vs 4.6 mg/L, 195.3 vs 28.9 pg/mL, 173 vs 118 ng/mL, respectively, ppi.05). CRP, M-CSF, and IL-3 were all increased in patients with chronic stable CHD relative to controls. These findings suggest that these are new inflammatory biomarkers that may have important roles in the development of atherosclerotic lesions. 相似文献
83.
Canda AE Sevinc AI Kocdor MA Canda T Balci P Saydam S Harmancioglu O 《Clinical breast cancer》2007,7(8):638-643
Breast cancer is the most common malignancy in women. However, metastases to the breast from nonmammary malignant neoplasms are rare and were detected at a rate of 0.28% in our series. Clinical and pathologic findings in 5 cases of metastatic tumors (malign mesenchymal tumor, squamous cell carcinoma of the tongue, non-Hodgkin lymphoma, and Sézary syndrome) in the breast are presented and discussed with respect to the literature. Detailed clinical history and a multidisciplinary approach are useful in establishing correct diagnosis and preventing unnecessary radical surgery. 相似文献
84.
Akbayir O Gedikbasi A Akyol A Numanoglu C Koroglu N Gulkilik A 《The journal of obstetrics and gynaecology research》2011,37(8):1126-1131
Benign cystic mesothelioma (BCM) is a rare tumor of unknown origin, most frequently encountered in women of reproductive age and with unknown etiology. Most patients have a history of previous pelvic operation, endometriosis, or pelvic inflammatory disease. Preoperative diagnosis is difficult. We report the cases of three patients, with one case complicated by pregnancy, and discuss the diagnostic evaluation and treatment of this rare disease. Complete surgical resection is recommended if feasible. However, recurrent disease is not uncommon. Clinical positive effects of different adjuvant medical treatments are also discussed. 相似文献
85.
Iskeleli G Bilgeç MD Arici C Atalay E Oğreden T Aydin A 《The Turkish journal of pediatrics》2011,53(6):692-694
Richner-Hanhart syndrome (tyrosinemia type II) is a rare autosomal recessive disease associated with high serum tyrosine levels caused by the deficiency of tyrosine aminotransferase enzyme. We report a 15-year-old female patient with complaints of bilateral photophobia and tearing, which started during the infancy period. Biomicroscopic examination revealed bilateral circular corneal opacities on the inferior quadrant and small dendritic lesions at the center of the circular opacities. Blood tests showed a tyrosine level of 508 micromol/L (normal range: 30-150). On her dermatologic examination, plantar hyperkeratosis and seborrheic dermatitis were noted, and mild mental retardation was detected. One and a half months after the tyrosine- and phenylalanine-restricted diet, her tyrosine level dropped to 395 micromol/L level, her corneal lesions subsided, and a symptomatic relief was achieved. Tyrosinemia type II should be suspected in patients demonstrating dermatologic signs, especially palmoplantar keratosis, associated with bilateral pseudodendritic corneal lesions unresponsive to antiviral therapy. 相似文献
86.
Subasi Sevgi Kucuk Kubra Demirci San Senar Cefle Ayse Tokuc Ecem Onder Balci Sibel Yazici Ayten 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(11):3543-3552
Graefe's Archive for Clinical and Experimental Ophthalmology - The aim of this study was to investigate changes in both macular and peripapillary retinal microcirculation in the subclinical... 相似文献
87.
Ceyhan C Unal S Yenisey C Tekten T Ceyhan FB 《The international journal of cardiovascular imaging》2008,24(3):253-259
The utility of N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) and Brain Natriuretic Peptide (BNP) for detecting left
ventricular (LV) diastolic dysfunction in hypertensive patients without heart failure symptoms is unclear. In this study,
we investigated the relation between NT-proBNP plasma levels and LV diastolic dysfunction in hypertensive patients without
systolic dysfunction. Method: We studied 40 ambulatory patients (26 women, mean age 52 ± 5) with controlled hypertension. LV diastolic function was assessed
with conventional Doppler, by means of mitral inflow and with tissue Doppler echocardiography by means of mitral annulus.
The ratio of early diastolic transmitral E wave velocities to tissue Doppler mitral annulus early diastolic E' wave velocities
(E/E′), was used to detect LV filling pressures. Patients were divided in three groups according to E/E′ ratios < 10 (group I), E/E′ ratios 'between' 10 and 15 (group II) and E/E′ ratios > 15 (group III). Plasma concentrations of NT-proBNP were measured by electro chemiluminescence's immunoassay. Results: The NT-proBNP blood levels were positively correlated significantly with E/E′ ratio (r = 0.80, P < 0.0001). Patients with elevated LV end diastolic pressure (LVEDP), defined as E/E′ > 15 (n = 8) had highest NT-proBNP (203 ± 75 pg/ml) levels. E/E′ 10 to 15 group (n = 16) had a mean NT-proBNP level of 71 ± 26 pg/ml, and those with E/E′ < 10 (n = 16) had 39 ± 20 pg/ml. A NT-proBNP value of 119 pg/ml had a sensitivity of 87%, a specificity of 100% for predicting
E/E′ > 15. Conclusion: The assessment of the blood concentration of NT-proBNP is of potential value for identification of those patients with hypertension
to detect early cardiovascular changes, especially LV diastolic dysfunction. 相似文献
88.
Akçora B Altuğ ME Balci A Hakverdi S Yönden Z Akbaş A Oztürk A Karazincir S Ozyurt H 《Journal of pediatric surgery》2008,43(10):1879-1884
Aim
This study was designed to investigate effect of gradual detorsion on testicular ischemia reperfusion injury.Materials and Methods
A total of 21 male rats were divided into 3 groups, each containing 7 rats. Torsion was created by rotating the left testis 720° in a clockwise direction. Group 1 underwent sham operation. Group 2 (sudden detorsion) served as a torsion/detorsion group, receiving 2 hours torsion and 2 hours detorsion. In group 3, 360° detorsion was done for 20 minutes after 720° torsion for 2 hours. Then, testis was done full detorsion for 100 minutes. At the end of the experiments (fourth hour), left orchiectomy was performed to measure the tissue levels of malondialdehyde (MDA), superoxide dismutase, and glutathione peroxidase and to perform histologic examination in testes.Results
The MDA levels of testis tissues were significantly increased in the sudden detorsion group as compared with the sham group. We found decrease of the MDA level in gradual detorsion group, but it was not a statistically significant amount. Significant decrease was found in the superoxide dismutase and glutathione peroxidase activities in the sudden detorsion group as compared with the sham and gradual detorsion groups. Histologic examinations were in accordance with the testicular tissue MDA levels.Conclusion
In the light of our biochemical and histopathologic findings, we can say that gradual detorsion has a trend to decrease the degree of testicular reperfusion injury in the rat torsion/detorsion model. 相似文献89.
Background In this study two different quality of life items are compared, and correlation of patient satisfaction with preoperative
and postoperative symptoms after laparoscopic Nissen fundoplication (LNF) for chronic gastroesophageal reflux disease is evaluated.
Materials and Methods Between December 2002 and December 2004, 60 patients with a diagnosis of chronic gastroesophageal reflux disease scheduled
for laparoscopic Nissen fundoplication were recruited prospectively and volunteered to participate in this study. Patients
underwent endoscopy, and their disease-specific symptoms were scored on a scale. Quality of life was measured preoperatively
and in the first and sixth postoperative months with two questionnaires: Short Form-36 (SF 36) (preoperatively) and the Gastroesophageal
Reflux Disease—Health-Related Quality of Life (GERD-HRQL) (postoperatively).
Results In more than 90% of the patients, typical symptoms (regurgitation and pyrozis) were controlled postoperatively (p < 0.001). In the first postoperative month, however, dysphagia (early dysphagia) was seen in 46 (76%) patients, whereas in
the sixth postoperative month (late dysphagia) its incidence decreased to only 2 (3.3%) patients. Similarly, in the first
postoperative month 42 (70%) patients had gas bloating, but the incidence of this symptom decreased to 26 (43.3%) patients
by the sixth month (p = 0.01). The quality-of-life measurements obtained from both SF 36 and GERD-HRQL showed that quality of life of the patients
improved significantly in the related domain of each item after surgery (p < 0.001).
Conclusions Laparoscopic Nissen fundoplication is an effective operation that controls the typical symptoms and improves the quality of
life of patients, but new-onset symptoms affect postoperative well-being. For closer evaluation of the benefits of the operation,
we need new questionnaires that comprehensively evaluate the symptom spectrum of GERD both preoperatively and postoperatively. 相似文献
90.