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J. Zeidler A. Lange S. Braun R. Linder S. Engel F. Verheyen J.-M. Graf von der Schulenburg 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2013,56(3):430-438
Claims data have proven useful for carrying out cost-of-illness studies. To avoid overestimating disease-related costs, only those costs that are related to a specific disease should be considered. The present study demonstrates two basic approaches for identifying disease-related costs. Using the example of attention-deficit hyperactivity disorder (ADHD), the advantages and drawbacks of expert-based approaches and those based on control groups are compared. Anonymized data from the “Techniker Krankenkasse” for 2008 were available for the study. The study population encompassed all ADHD patients and a control group that was five times bigger. Additionally, a systematic literature review was carried out on 65 relevant studies. Compared with the control group, disease-related costs were EUR 2,902 per ADHD patient on average. However, using the expert-based approach, costs were established to be EUR 923 lower. This is mainly because a comparison with an appropriate control group incorporates all costs for possible comorbidities and concomitant diseases. Both approaches have specific advantages and drawbacks, and when planning studies the respective limitations need to be considered. 相似文献
993.
Geertje J. Dreyer Koen E. Groeneweg Sebastiaan Heidt Dave L. Roelen Melissa van Pel Helene Roelofs Volkert A. L. Huurman Ingeborg M. Bajema Dirk Jan A. R. Moes Willem E. Fibbe Frans H. J. Claas Cees van Kooten Rabelink J. Rabelink Johan W. de Fijter Marlies E. J. Reinders 《American journal of transplantation》2020,20(10):2905-2915
Mesenchymal stromal cells (MSC) hold promise as a novel immune‐modulatory therapy in organ transplantation. First clinical studies have used autologous MSCs; however, the use of allogeneic "off‐the‐shelf" MSCs is more sustainable for broad clinical implementation, although with the risk of causing sensitization. We investigated safety and feasibility of allogeneic MSCs in renal transplantation, using a matching strategy that prevented repeated mismatches. Ten patients received two doses of 1.5 × 106/kg allogeneic MSCs 6 months after transplantation in a single‐center nonrandomized phase Ib trial, followed by lowering of tacrolimus (trough level 3 ng/mL) in combination with everolimus and prednisone. Primary end point was safety, measured by biopsy proven acute rejection (BPAR) and graft loss 12 months after transplantation. Immune monitoring was performed before and after infusion. No BPAR or graft loss occurred and renal function remained stable. One patient retrospectively had DSAs against MSCs, formed before infusion. No major alterations in T and B cell populations or plasma cytokines were observed upon MSC infusion. Administration of HLA selected allogeneic MSCs combined with low‐dose tacrolimus 6 months after transplantation is safe at least in the first year after renal transplantation. This sets the stage to further explore the efficacy of third‐party MSCs in renal transplantation. 相似文献
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Gert-Jan van der Putten Henk S. Brand Jos M. G. A. Schols Cees de Baat 《Clinical oral investigations》2011,15(2):185-192
The study objective was to explore the diagnostic suitability of the Xerostomia Inventory and the association between xerostomia,
hyposalivation and medication use in a group of nursing home residents. A cross-sectional study was carried out in 50 physically
impaired nursing home residents (20 men) with a mean age of 78.1 years (range, 53–98) in The Netherlands. The Xerostomia Inventory-Dutch
version was completed for all residents and the data were subjected to exploratory factor analysis to determine the diagnostic
suitability. Residents’ data on xerostomia, whole saliva secretion rates and hyposalivation-related medications used were
collected and statistically analyzed. The diagnostic suitability of the Xerostomia Inventory-Dutch version appeared restricted.
The prevalence of xerostomia was 52%, without gender and age difference. The prevalence of hyposalivation was 24% for resting,
60% for chewing-stimulated and 18% for acid-stimulated whole saliva. All whole saliva secretion rates were significantly lower
in women than in men and in older than in younger residents. Forty-four percent of all medications used were hyposalivation-related
and women used significantly more medications than men. Xerostomia was significantly negatively correlated with the resting
whole saliva secretion rate. The number of hyposalivation-related medications used was not significantly correlated with the
various whole saliva secretion rates. In nursing home residents, xerostomia, hyposalivation and using hyposalivation-related
medications seem common and partially associated features. 相似文献
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