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71.
Roberta Petrucci Giulia Lombardi Ilaria Corsini Francesca Visciotti Antonio Pirodda Salvatore Cazzato Maria Paola Landini Paola Dal Monte 《Journal of clinical microbiology》2015,53(1):336-338
The diagnosis of tuberculosis (TB) is difficult in children, especially for smear-negative pulmonary and extrapulmonary TB, which are common at this age. We report an 11-year-old girl with TB otitis media with negative smear microscopy and Xpert MTB/RIF but positive Mycobacterium tuberculosis-specific transrenal DNA (Tr-MTB-DNA) test results and culture for M. tuberculosis. 相似文献
72.
Cazzato Massimiliano Neri Rossella Possemato Niccolo Puccini Rodolfo Bombardieri Stefano 《Clinical rheumatology》2010,29(1):33-38
To examine the incorporation of anti-CCP antibodies into the American College of Rheumatology (ACR) classification criteria
for rheumatoid arthritis (RA) and to evaluate the advantages of the revised anti-CCP criteria in diagnosing Chinese patients.
Patients who suffered from arthritic problems during the recent 2 years were selected from the Department of Rheumatology
and Immunology of Peking University People's Hospital. The patients were divided into RA group and non-RA group according
to the clinical diagnosis by experienced rheumatologists. The ACR criteria were revised in three ways: (1) replacement of
rheumatoid nodules and erosions as criteria with anti-CCP antibodies (RA-6 criteria); (2) replacement of rheumatoid nodules
with anti-CCP antibodies as a criterion (RA-7 criteria); (3) addition of anti-CCP antibodies (RA-8 criteria). The diagnostic
value of ACR criteria and anti-CCP revised criteria (RA-6, RA-7, and RA-8) were evaluated by comparing the sensitivity and
specificity of all criteria, in all subjects and in subjects with arthritis symptoms within 2 years. There were 604 patients
included in the study totally, among whom 312 patients were diagnosed as RA and 292 were diagnosed as other rheumatic diseases
by rheumatologists. For all the RA patients, the sensitivity and specificity of anti-CCP antibodies were 76.2% and 96%, respectively.
Its specificity was much higher than RF (85.2%). For the patients with a disease duration less than two years, the sensitivities
were 82.0%, 91.0%, 87.0%, and 87.0%, while the specificities were 95.6%, 83.9%, 95.6%, and 95.6%, respectively, according
to 1987 ACR criteria, RA-6, RA-7, and RA-8 criteria. Among all the RA patients, the corresponding sensitivities were 92.3%,
96.8%, 94.6%, and 94.6%, and the specificities were 92.8%, 83.6%, 92.8%, and 92.8%, respectively. The 1987 ACR criteria have
high sensitivity and specificity in established RA, but are less sensitive in early RA. The RA-6 criteria improve the sensitivity
by reducing its specificity. The RA-7 criteria with replacement of rheumatoid nodules by anti-CCP antibodies increase the
sensitivity without losing specificity, which may serve as new classification criteria in routine clinical practice, especially
in early RA patients. 相似文献
73.
Different responses to rivastigmine in subcortical vascular dementia and multi-infarct dementia 总被引:1,自引:0,他引:1
Moretti R Torre P Antonello RM Cazzato G Pizzolato G 《American journal of Alzheimer's disease and other dementias》2008,23(2):167-176
Vascular dementia (VaD) is associated with a large amount of heterogeneity, as it groups together a broad category of patients in whom various manifestations of cognitive decline are attributed to cerebrovascular or cardiovascular disease. Thus, a study was designed to determine the effects of rivastigmine on cognitive function, global daily living performance, and behavioral disorders in VaD patients versus an active control (nimodipine), stratifying patients according to the type of VaD, subcortical vascular dementia (sVAD), and multi-infarct dementia (MID). The trial was a prospective study. This study shows that long-term treatment with rivastigmine, at dosages approved for therapeutic use in Alzheimer's disease, produces significant improvement in all behavioral symptoms in 2 forms of VaD, MID and sVaD, except delusions. It also suggests that rivastigmine may enable a reduction in concomitant neuroleptics and benzodiazepines in VaD, especially in MID. The results are discussed with an overview of the literature. 相似文献
74.
75.
76.
Oliva Antonio Grassi Simone Cazzato Francesca Jabbehdari Sayena Mensi Lorenzo Amorelli Giulia Orazi Lorenzo Arena Vincenzo Lepore Domenico 《International journal of legal medicine》2022,136(4):1009-1016
International Journal of Legal Medicine - As retinal hemorrhage (RH) is the most frequent and reliable finding of abusive head trauma (AHT), an ophthalmology consultation should be systematically... 相似文献
77.
Roberto Luigi Cazzato Xavier Buy Omer Eker Thierry Fabre Jean Palussiere 《European radiology》2014,24(12):3059-3068
Objective
To review our 10-year experience with percutaneous long bone cementoplasty (PLBC) in poor surgical patients.Materials and methods
Fifty-one patients were included. Primary endpoints were pain and functional outcomes one month following PLBC. A secondary endpoint dealt with factors predicting cement leakage. Delayed adverse events and overall survival (OS) were also investigated.Results
Sixty-six lesions were treated. Local pain relief at 1-month occurred in 59/66 lesions (89.4 %); pain improvement was significantly more common for lesions of the upper limb (p?0.05). Limb functionality at one month improved in 46/64 lesions (71.8 %); lesions?≤?3 cm showed better outcomes in terms of limb function (p <0.05). Cement leakage was minor and asymptomatic in 26 cases (26/66, 39.4 %); in one case (1/66, 1.5 %) symptomatic minor amount of intra-articular cement leakage occurred. Factors predicting cement leakage were diaphyseal location of the lesions, cortical bone disruption and extra-bone tumour extension (p?0.05). The most common delayed adverse event was fracture (6/66, 9.1 %). OS at 1-, 2- and 3-years was 61.2 %, 30.9 % and 23.0 %, respectively.Conclusions
For poor surgical candidates, at 1-month follow-up, PLBC proved to be safe and effective. If stress fracture occurs following PLBC, surgical external fixation is still an affordable therapeutic option.Key Points
? Percutaneous long bone cementoplasty may be proposed to poor surgical patients ? Pain palliation is more significant for lesions of the upper limb ? Limb function improves significantly for lesions sized?≤?3 cm ? Fracture is the most common delayed adverse event (9 % of cases) ? If cement stress fracture occurs, surgical external fixation is still feasible 相似文献78.
Zorzon M Zivadinov R Bosco A Bragadin LM Moretti R Bonfigli L Morassi P Iona LG Cazzato G 《Multiple sclerosis (Houndmills, Basingstoke, England)》1999,5(6):418-427
Sexual dysfunction is a very important but often overlooked symptom of multiple sclerosis. To investigate the type and frequency of symptoms of sexual dysfunction in patients suffering from multiple sclerosis, we performed a case-control study comparing 108 unselected patients with definite multiple sclerosis, 97 patients with chronic disease and 110 healthy individuals with regard to sexual function, sphincteric function, physical disorders impeding sexual activity and the impact of sexual dysfunction on social life. Information has been collected from a face-to-face structured interview performed by a doctor of the same gender as the patient. The disability, the cognitive performances, the psychiatric conditions and the psychological profile of patients and controls have been assessed. Sexual dysfunction was present in 73.1% of cases, in 39.2% of chronic disease controls and in 12.7% of healthy controls (P<0.0001). Male cases reported symptoms of sexual dysfunction more frequently than female cases (P<0.002). Symptoms of sexual dysfunction more commonly reported in patients with multiple sclerosis were anorgasmia or hyporgasmia (37.1%), decreased vaginal lubrication (35.7%) and reduced libido (31.4%) in women, and impotence or erectile dysfunction (63.2%), ejaculatory dysfunction and/or orgasmic dysfunction (50%) and reduced libido (39.5%) in men. Seventy-five per cent of cases, 51.5% of chronic disease controls and 28.2% of healthy controls (P<0.0001) experienced symptoms of sphincteric dysfunction. In conclusion, a substantial part of our sample of patients with multiple sclerosis reported symptoms of sexual and sphincteric dysfunction. Both sexual and sphincteric dysfunction were significantly more common in patients with multiple sclerosis than in either control group. Our findings suggest that a peculiar damage of the structures involved in sexual function is responsible for the dysfunction in patients with multiple sclerosis, but the highly significant lower frequency of symptoms of depression and anxiety in healthy controls may also imply a possible causative role of psychological factors. 相似文献
79.
Moretti R Torre P Antonello RM Cattaruzza T Cazzato G 《Dementia and geriatric cognitive disorders》2005,20(2-3):158-162
Corticobasal degeneration (CBD) is a rare disorder, which normally includes a combination of neurobehavioural features, movement disorders and other manifestations. It is now recognized that CBD patients usually present with two phenotypes: the lateralized phenotype and the dementia phenotype. The aim of our work was to determine the nature and the progression of cognitive and behavioural impairment in 10 lateralized CBD patients. In our patients, the most salient aspects of cognitive impairment were: an evident alteration of rapid alternating operative strategies, associated with the evident impairment of set shifting, of executive operations, of operative and sequential procedure and of implementation of judgement and abstract reasoning. The self-activation of retrieval processes is partly preserved in CBD. As all the other types of subcortical impairments, even CBD encompasses both cognitive impairment as well as a wide range of behaviour disturbances, such as progressive alterations of sleep, depression, and of anxiety (with a remarkable incidence of somatic pain). This suggests that in addition to neuropsychological assessment, quantification of the personality behaviour disorder is important for standardizing the diagnosis of subcortical vascular dementia and distinguishing it from any other dementias. 相似文献
80.
13C-breath tests in the study of microsomal liver function 总被引:3,自引:0,他引:3
Nista EC Fini L Armuzzi A Candelli M Zocco MA Cazzato IA Merra G Finizio R Miele L Grieco A Gasbarrini G Gasbarrini A 《European review for medical and pharmacological sciences》2004,8(1):33-46
Conventional liver tests can be used to estimate a mixture of injury and function but none of these may be regarded as a reliable marker either to quantify functional hepatic reserve or to reflect life-threatening complications of acute and chronic liver diseases. To overcome this limit, many dynamic tests have been developed in order to evaluate the "hepatic functional mass". Among these tests we can include breath tests with 13C-labeled substrates undergoing different metabolic pathways. As concerning the evaluation of microsomal function, two main categories of breath tests have been developed based on the limiting step in the different substrates metabolism. The first group include aminopyrine, caffeine and diazepam, all substrates with a metabolism independent from hepatic blood flow and dependent almost exclusively from the enzymatic activity of different cytochromes P450. The other group is composed of substrates with flow dependent metabolism like methacetin, phenacetin, erythromycin. The aim of this review is to describe the clinical applications of microsomal liver breath tests in different hepatic diseases. 相似文献