Correction to: Prognostic significance of serum inflammatory markers in esophageal cancer

Esophagus - In the original publication of the article, under the section “Clinicopathological characteristics”, the thresholds     

Sensor Measures of Symmetry Quantify Upper Limb Movement in the Natural Environment Across the Lifespan

Knowledge of upper limb activity in the natural environment is critical for evaluating the effectiveness of rehabilitation services. Wearable sensors allow efficient collection of these data and have the potential to be less burdensome than self-report measures of activity. Sensors can capture many different variables of activity and daily performance, many of which could be useful in identifying deviation from typical movement behavior or measuring outcomes from rehabilitation interventions. Although it has potential, sensor measurement is just emerging, and there is a lack of consensus regarding which variables of daily performance are valid, sensitive, specific, and useful. We propose that symmetry of full-day upper limb movement is a key variable. We describe here that symmetry is valid, robustly observed within a narrow range across the lifespan in typical development, and shows evidence of being different in populations with neuromotor impairment. Key next steps include the determination of sensitivity, specificity, minimal detectable change, and minimal clinically important change/difference. This information is needed to determine whether an individual belongs to the typical or atypical group, whether change has occurred, and whether that change is beneficial.     

Co-Construction of an Intervention Model Using Sports in a Rehabilitation Setting: A Collaboration Between Researchers and Practitioners

The objective of this article is to develop an explanatory model of how a rehabilitation intervention functions within a sports context. Participants include three Coach-Educators (CEs) who organize and set up a rehabilitation intervention using ice hockey. In order to develop the model, two focus groups using the co-modeling methodology of Basque and Pudelko (2004) were conducted. Based on their experiences, the CEs illustrated and modeled the functioning of their intervention. A concept mapping software was projected on a screen to follow the co-modeling in real time. The first discussion group provided a first draft of the model which served as a starting point for the second. The data were analyzed in light of the Theory of change (Weiss, 1998). The CEs report that the objective of the intervention is social integration. This objective can be achieved either through the interaction of the activity components (i.e., youth, group, CEs, ice hockey, structured aspects), or by the CEs’ interventions involving four mechanisms: strengthening self-esteem, moving focus from oneself to others, destigmatization, and learning of prosocial behaviors. Many factors, such as gender, expertise and participants’ experiences were identified as having a positive or negative effect on achieving the objective of the program. Practical considerations and future research avenues are presented. For example, practitioners who use sport in the context of rehabilitation should be familiar with the characteristics and difficulties of the adolescents in Youth Centers and have a clinical rationale in relation to the problem underlying the intervention and its objective.     

Health benefits of resveratrol: Evidence from clinical studies

Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing. Resveretrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. The molecular basis for the pleiotropic activities of resveratrol are based on its ability to modulate multiple cell signaling molecules such as cytokines, caspases, matrix metalloproteinases, Wnt, nuclear factor-κB, Notch, 5′-AMP-activated protein kinase, intercellular adhesion molecule, vascular cell adhesion molecule, sirtuin type 1, peroxisome proliferator-activated receptor-γ coactivator 1α, insulin-like growth factor 1, insulin-like growth factor-binding protein 3, Ras association domain family 1α, pAkt, vascular endothelial growth factor, cyclooxygenase 2, nuclear factor erythroid 2 like 2, and Kelch-like ECH–associated protein 1. Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use. In this regard, the recently produced micronized resveratrol formulation called SRT501, shows promise. This review discusses the currently available clinical data on resveratrol in the prevention, management, and treatment of various diseases and disorders. Based on the current evidence, the potential utility of this molecule in the clinic is discussed.     

Challenges of adopting the role of care manager when implementing the collaborative care model for people with common mental illnesses: A scoping review

This review aimed to identify the main factors influencing the adoption of the role of care manager (CM) by nurses when implementing the collaborative care model (CCM) for common mental illnesses in primary care settings. A total of 19 studies met the inclusion criteria, reporting on 14 distinct interventions implemented between 2000 and 2017 in five countries. Two categories of factors were identified and described as follows: (i) strategies for the CCM implementation (e.g. initial care management training and supervision by a mental health specialist) and (ii) context‐specific factors (e.g. organizational factors, collaboration with team members, nurses’ care management competency). Identified implementation strategies were mainly aimed towards improving the nurse's care management competency, but their efficacy in developing the set of competencies needed to fulfil a CM role was not well demonstrated. There is a need to better understand the relationship between the nurses’ competencies, the care management activities, the strategies used to implement the CCM and the context‐specific factors. Strategies to optimize the adoption of the CM role should not be solely oriented towards the individual's competency in care management, but also consider other context‐specific factors. The CM also needs a favourable context in order to perform his or her activities with competency.