全文获取类型
收费全文 | 5603篇 |
免费 | 540篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 232篇 |
妇产科学 | 154篇 |
基础医学 | 764篇 |
口腔科学 | 81篇 |
临床医学 | 822篇 |
内科学 | 959篇 |
皮肤病学 | 74篇 |
神经病学 | 487篇 |
特种医学 | 231篇 |
外科学 | 871篇 |
综合类 | 215篇 |
现状与发展 | 20篇 |
一般理论 | 6篇 |
预防医学 | 555篇 |
眼科学 | 76篇 |
药学 | 281篇 |
中国医学 | 7篇 |
肿瘤学 | 305篇 |
出版年
2023年 | 85篇 |
2022年 | 66篇 |
2021年 | 175篇 |
2020年 | 105篇 |
2019年 | 136篇 |
2018年 | 200篇 |
2017年 | 149篇 |
2016年 | 160篇 |
2015年 | 164篇 |
2014年 | 196篇 |
2013年 | 257篇 |
2012年 | 311篇 |
2011年 | 406篇 |
2010年 | 197篇 |
2009年 | 198篇 |
2008年 | 250篇 |
2007年 | 251篇 |
2006年 | 250篇 |
2005年 | 253篇 |
2004年 | 209篇 |
2003年 | 188篇 |
2002年 | 178篇 |
2001年 | 119篇 |
2000年 | 114篇 |
1999年 | 120篇 |
1998年 | 76篇 |
1997年 | 60篇 |
1996年 | 81篇 |
1995年 | 59篇 |
1994年 | 43篇 |
1993年 | 47篇 |
1992年 | 60篇 |
1991年 | 77篇 |
1990年 | 65篇 |
1989年 | 62篇 |
1988年 | 74篇 |
1987年 | 46篇 |
1986年 | 61篇 |
1985年 | 52篇 |
1984年 | 51篇 |
1983年 | 48篇 |
1982年 | 43篇 |
1981年 | 26篇 |
1980年 | 29篇 |
1979年 | 34篇 |
1978年 | 33篇 |
1974年 | 28篇 |
1973年 | 34篇 |
1972年 | 21篇 |
1967年 | 23篇 |
排序方式: 共有6172条查询结果,搜索用时 0 毫秒
41.
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor 总被引:13,自引:0,他引:13
Fox CJ Hammerman PS Cinalli RM Master SR Chodosh LA Thompson CB 《Genes & development》2003,17(15):1841-1854
42.
Casey Graham; Plummer Sarah; Hoeltge Gerald; Scanlon David; Fasching Clare; Stanbridge Eric J. 《Human molecular genetics》1993,2(11):1921-1927
Rearrangements or deletions of chromosome 17 are the most frequentlyobserved genetic changes identified in breast tumors. Molecularanalyses suggest that in addition to the p53 gene on 17p13.1there may be at least three other tumor suppressor genes onchromosome 17 involved in breast cancer. Regions of loss ofheterozygosity (LOH) identified on 17p13.3 and 17q12-qter occurfrequently in breast tumors, and the BRCA-1 gene has been mappedto 17q21 by genetic linkage analysis. Here we provide biologicalevidence for the presence of a growth suppressor gene(s) onchromosome 17 that results In the In vitro growth suppressionof the p53 wild-type MCF 7 breast cancer cell line. We haveIntroduced a normal chromosome 17 into MCF 7 cells by microcellmediatedchromosome transfer (MMCT), and demonstrate that cells growtharrest before 10 to 12 population doublings. In contrast, theintroduction of a normal chromosome 13 had no effect upon growthof these cells either In vitro or In vivo. These data providedirect functional evidence for the presence of a growth suppressorgene(s) on chromosome 17, which is not p53, and which may representone of several gene(s) that play a critical role in the developmentof breast cancer. 相似文献
43.
Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH; Washburn LL; McCarrey JR; Cattanach BM; Lovell-Badge R; Burgoyne PS 《Human molecular genetics》1998,7(4):715-727
An RNA-binding motif (RBM) gene family has been identified on the human Y
chromosome that maps to the same deletion interval as the 'azoospermia
factor' (AZF). We have identified the homologous gene family (Rbm) on the
mouse Y with a view to investigating the proposal that this gene family
plays a role in spermatogenesis. At least 25 and probably >50 copies of
Rbm are present on the mouse Y chromosome short arm located between Sry and
the centromere. As in the human, a role in spermatogenesis is indicated by
a germ cell-specific pattern of expression in the testis, but there are
distinct differences in the pattern of expression between the two species.
Mice carrying the deletion Yd1, that maps to the proximal Y short arm, are
female due to a position effect resulting in non-expression of Sry ;
sex-reversing such mice with an Sry transgene produces males with a high
incidence of abnormal sperm, making this the third deletion interval on the
mouse Y that affects some aspect of spermatogenesis. Most of the copies of
Rbm map to this deletion interval, and the Yd1males have markedly reduced
Rbm expression, suggesting that RBM deficiency may be responsible for, or
contribute to, the abnormal sperm development. In man, deletion of the
functional copies of RBM is associated with meiotic arrest rather than
sperm anomalies; however, the different effects of deletion are consistent
with the differences in expression between the two species.
相似文献
44.
45.
46.
Cerebral Processing of Acute Skin and Muscle Pain in Humans 总被引:12,自引:0,他引:12
47.
48.
Compliance with oral theophylline therapy in asthmatic children 总被引:1,自引:0,他引:1
Serum theophylline levels were obtained from 111 children on continuous theophylline therapy when seen in the emergency department for acute episodes of wheezing. Sixty-six percent of patients were at least partially compliant and only 34% were noncompliant in medication taking on the basis of a serum theophylline level of less than 5 micrograms/mL. The main factors associated with compliance were type of primary care source, whether the patient had difficulty keeping appointments, and the relationship of the caretaker to the patient. 相似文献
49.
50.