全文获取类型
收费全文 | 8658篇 |
免费 | 802篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 89篇 |
儿科学 | 386篇 |
妇产科学 | 121篇 |
基础医学 | 1151篇 |
口腔科学 | 166篇 |
临床医学 | 982篇 |
内科学 | 1498篇 |
皮肤病学 | 103篇 |
神经病学 | 696篇 |
特种医学 | 490篇 |
外科学 | 1268篇 |
综合类 | 228篇 |
现状与发展 | 1篇 |
一般理论 | 3篇 |
预防医学 | 882篇 |
眼科学 | 199篇 |
药学 | 692篇 |
中国医学 | 34篇 |
肿瘤学 | 508篇 |
出版年
2023年 | 49篇 |
2022年 | 53篇 |
2021年 | 119篇 |
2020年 | 84篇 |
2019年 | 109篇 |
2018年 | 159篇 |
2017年 | 147篇 |
2016年 | 130篇 |
2015年 | 179篇 |
2014年 | 252篇 |
2013年 | 345篇 |
2012年 | 416篇 |
2011年 | 417篇 |
2010年 | 326篇 |
2009年 | 306篇 |
2008年 | 397篇 |
2007年 | 449篇 |
2006年 | 384篇 |
2005年 | 348篇 |
2004年 | 353篇 |
2003年 | 306篇 |
2002年 | 315篇 |
2001年 | 272篇 |
2000年 | 243篇 |
1999年 | 225篇 |
1998年 | 192篇 |
1997年 | 154篇 |
1996年 | 173篇 |
1995年 | 153篇 |
1994年 | 124篇 |
1993年 | 91篇 |
1992年 | 186篇 |
1991年 | 172篇 |
1990年 | 143篇 |
1989年 | 136篇 |
1988年 | 136篇 |
1987年 | 138篇 |
1986年 | 113篇 |
1985年 | 140篇 |
1984年 | 110篇 |
1983年 | 86篇 |
1982年 | 67篇 |
1981年 | 66篇 |
1980年 | 60篇 |
1979年 | 77篇 |
1978年 | 55篇 |
1977年 | 52篇 |
1976年 | 40篇 |
1974年 | 46篇 |
1972年 | 33篇 |
排序方式: 共有9497条查询结果,搜索用时 109 毫秒
51.
52.
53.
M Durdu† S Gökçe‡ M Bagirova§ M Yalaz‡ AM Allahverdiyev§ S Uzun† 《Journal of the European Academy of Dermatology and Venereology》2007,21(2):214-218
OBJECTIVE: Although cutaneous leishmaniasis (CL) occurs mostly in the facial area, periocular involvement accounts for 2-5% of the facial lesions. CL lesions localized in the periocular region can easily be confused with various other diseases. The aim of this study was to examine the frequency of periocular involvement in CL in the Cukurova region of Turkey, as well as the clinical characteristics, diagnosis and methods of treatment of this disease. METHODS: Between December 1998 and December 2004, patients who were diagnosed with CL were evaluated prospectively with respect to periocular involvement. RESULTS: From the 2066 patients evaluated with CL, 2622 lesions were identified. In 59 (2.9%) of these patients, a total of 66 (2.5%) lesions were located in the periocular area. Thirty-two (48.5%) of these lesions were of the papular type, 15 (22.7%) the nodulo-ulcerative type, 10 (15.2%) the plaque type, and nine (13.6%) the nodular type. Dacryocystitis was identified in four patients with periocular involvement. Over the follow-up period, no ocular or periocular deformities or complications developed in these patients. CONCLUSION: Patients suspected of CL should be evaluated and treated early in the course of their disease to prevent any permanent ocular or periocular deformities. 相似文献
54.
55.
56.
57.
L. C. Walker C. A. Parker W. J. Lipinski M. J. Callahan R. T. Carroll S. E. Gandy J. D. Smith M. Jucker C. L. Bisgaier 《The American journal of pathology》1997,151(5):1371-1377
To assess the influence of age and diet on cerebral pathology in mice lacking apolipoprotein E (apoE), four male apoE knockout mice (epsilon -/-), and five male wild-type (epsilon +/+) littermate controls were placed on a high-fat/high-cholesterol diet for 7 weeks beginning at 17 months of age. All four aged knockout mice developed xanthomatous lesions in the brain consisting mostly of crystalline cholesterol clefts, lipid globules, and foam cells. Smaller xanthomas were confined mainly to the choroid plexus and ventral fornix in the roof of the third ventricle, occasionally extending subpially along the choroidal fissure and into the adjacent parenchyma. More advanced xanthomas disrupted adjoining neural tissue in the fornix, hippocampus, and dorsal diencephalon; in one case, over 60% of one telencephalic hemisphere, including nearly the entire neocortex, was obliterated by the lesion. No xanthomas were observed in aged wild-type controls fed the high-fat/high-cholesterol diet. Brains from 42 additional animals, fed only conventional chow, were examined; 3 of 15 aged (15- to 23-month-old) apoE knockout mice developed small choroidal xanthomas. In contrast, no lesions were observed in five young (2- to 4-month-old) apoE knockout mice or in any wild-type controls between the ages of 2 and 23 months. Our findings indicate that disorders of lipid metabolism can induce significant pathological changes in the central nervous system of aged apoE knockout mice, particularly those on a high-fat/high-cholesterol diet. It may be fruitful to seek potential interactions between genetic factors and diet in modulating the risk of Alzheimer's disease and other neurodegenerative disorders in aged humans. 相似文献
58.
We present a comprehensive, meta‐analytic review and critical evaluation of outcome research pertaining to the effectiveness of premarital prevention programs. Results revealed that the mean effect size for premarital programs was .80, which means that the average person who participated in a premarital prevention program was significantly better off afterwards than 79% of people who did not participate. Stated differently, the average participant in a premarital program tends to experience about a 30% increase in measures of outcome success. Our findings suggest that premarital prevention programs are generally effective in producing immediate and short‐term gains in interpersonal skills and overall relationship quality and that these improvements are significantly better than nonintervention couples in these areas. However, because of a lack of extended follow‐up research, conclusions about long‐term effectiveness remain elusive. We propose implications for future research, education, and policy. 相似文献
59.
60.
R Dixon AM Hughes K Nairn M Sellers JV Kemp RA Yates 《Cephalalgia : an international journal of headache》1998,18(7):468-475
Zolmitriptan (ZomigTM ) is a 5HT1B/1D agonist which has the ability to cross the intact blood-brain barrier to access central as well as peripheral receptors. Because of the potential for central nervous system side effects, this randomized, double-blind, placebo-controlled, 6-period crossover study evaluated the effects of 2.5 and 5 mg doses of zolmitriptan on psychomotor performance and investigated any pharmacodynamic or pharmacokinetic interaction with diazepam. Twelve healthy volunteers received the following "treatments" as single doses: zolmitriptan 2.5 mg, zolmitriptan 5 mg, diazepam 10 mg, zolmitriptan 2.5 mg+diazepam 10 mg, zolmitriptan 5 mg+diazepam 10 mg and placebo. Pre-dose and at 1, 4, 8, and 24 h post-dose, the following validated battery of psychomotor tests was performed: Bond-Lader visual analogue scales (calmness, contentedness, and alertness factors), critical flicker fusion test, choice reaction time (recognition, motor, and total reaction times), finger-tapping test, number cancellation test and digit symbol substitution test. Plasma concentrations of zolmitriptan, its active metabolite, and diazepam and its active metabolites were measured at the same timepoints. Zolmitriptan 2.5 and 5 mg had no effect on psychomotor function when given alone. In contrast, diazepam 10 mg had profound effects, consistent with its sedative properties, but there was no synergism on concomitant administration of either dose of zolmitriptan. Plasma concentrations of zolmitriptan, diazepam, and their respective active metabolites were similar when the two drugs were given alone or in combination. 相似文献