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Alcohol consumption and mortality in Alameda County 总被引:7,自引:0,他引:7
The association between level of alcohol consumption and 15-year mortality, focusing particularly on the possible protective effect of light drinking compared to abstention, was studied in a representative population sample of 6928 residents of Alameda County, California. Because abstainers differ from light, moderate and heavy drinkers on a number of demographic, physical, and psychosocial characteristics, the role of these as confounders of the alcohol/mortality association was examined. Using multiple logistic models, the mortality experience of abstainers, moderate drinkers, heavy drinkers and very heavy drinkers was compared with that of light drinkers. Among men only, very heavy drinkers were at significantly greater risk of death from all causes than were light drinkers (OR = 2.5, p less than 0.01). Neither abstainers nor other drinkers were at significantly higher risk of death from ischemic heart disease than were light drinkers. This pattern of results persisted with adjustment for 11 covariates of alcohol consumption in addition to age. 相似文献
84.
Ramos-Trujillo E González-Acosta H Flores C García-Nieto V Guillén E Gracia S Vicente C Espinosa L Maseda MA Santos F Camacho JA Claverie-Martín F 《Journal of human genetics》2007,52(3):255-261
Mutations in the voltage-gated chloride/proton antiporter ClC-5 gene, CLCN5, are associated with Dent’s disease, an X-linked renal tubulopathy. Our interest is to identify and characterize disease-causing
CLCN5 mutations, especially those that alter the splicing of the pre-mRNA. We analyzed the CLCN5 gene from nine unrelated Spanish Dent’s disease patients and their relatives by DNA sequencing. Pre-mRNA splicing analysis
was performed by RT-PCR. Seven new mutations were identified, consisting of three missense mutations (C219R, F273L, and W547G),
one splice-site mutation (IVS-2A > G), one deletion (976delG), and two non-sense mutations (Y140X and W314X). We found that
missense mutation W547G also led to increased expression of a new alternative isoform lacking exons 10 and 11 that was expressed
in several human tissues. In addition, we describe another novel CLCN5 splicing variant lacking exon 11 alone, which was expressed only in human skeletal muscle. We conclude that missense mutation
W547G can also alter the expression levels of a CLCN5 mRNA splicing variant. This type of mutation has not been previously described in the CLCN5 gene. Our results support the importance of a routine analysis at the pre-mRNA level of mutations that are commonly assumed
to cause single amino acids alterations. 相似文献
85.
Surgical management of the recurrent laryngeal nerve in thyroidectomy: American Head and Neck Society Consensus Statement 下载免费PDF全文
Christopher E. Fundakowski MD Nishant Agrawal MD Marcin Barczyński MD Pauline M. Camacho MD Dana M. Hartl MD PhD Emad Kandil MD Whitney E. Liddy MD Travis J. McKenzie MD John C. Morris MD John A. Ridge MD PhD Rick Schneider MD Jonathan Serpell MD Catherine F. Sinclair MD Samuel K. Snyder MD David J. Terris MD R. Michael Tuttle MD Che‐Wei Wu MD Richard J. Wong MD Mark Zafereo MD Gregory W. Randolph MD 《Head & neck》2018,40(4):663-675
“I have noticed in operations of this kind, which I have seen performed by others upon the living, and in a number of excisions, which I have myself performed on the dead body, that most of the difficulty in the separation of the tumor has occurred in the region of these ligaments…. This difficulty, I believe, to be a very frequent source of that accident, which so commonly occurs in removal of goiter, I mean division of the recurrent laryngeal nerve.” Sir James Berry (1887) 相似文献
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Managing Osteoporosis in Patients on Long‐Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research 下载免费PDF全文
Robert A Adler Ghada El‐Hajj Fuleihan Douglas C Bauer Pauline M Camacho Bart L Clarke Gregory A Clines Juliet E Compston Matthew T Drake Beatrice J Edwards Murray J Favus Susan L Greenspan Ross McKinney Jr Robert J Pignolo Deborah E Sellmeyer 《Journal of bone and mineral research》2016,31(10):1910-1910
88.
Velia Ramírez-Amador Gabriela Anaya-Saavedra Erick Crespo-Solís Esther Irigoyen Camacho Imelda González-Ramírez Sergio Ponce-de-León 《Supportive care in cancer》2010,18(5):639-646
Purpose
Knowledge of oral mucositis (OM) in patients with acute leukemia (AL) and chemotherapy (CT) has remained limited. Thus, a prospective, longitudinal study was undertaken to characterize clinical features, associated risk factors, and behavior of OM in a cohort of AL patients starting CT. 相似文献89.
Francisco Miguel Camacho-Martínez Elena Rodríguez Rey Francisco Camacho Serrano Adriana Wagner 《Anais brasileiros de dermatologia》2013,88(3):387-394
While treatment of keloids and hypertrophic scars normally shows modest results, we found that treatment with bleomycin was more promising. The present study was divided into two parts. In the first part the aim was to show the results using a combination of bleomycin and triamcinolone acetonide per cm2 (BTA). In the second part the objective was to determine the response to both drugs in large keloids that were divided into 1 cm2 squares, treating each square with the dose previously used. In the first part of the study, the clinical response of 37 keloids ranging from 0.3 to 1.8 cm2 treated with BTA were followed up over a period of 1- 2 years. 0.375 IU bleomycin and 4 mg triamcinolone acetonide were injected every 3 months. In the second part of the study we reviewed the clinical response in six patients with large keloids. The monthly dose administered never exceeded 3 IU of bleomycin. The first study showed 36 keloids (97.29%) softening after the first dose. In the second study, 5 showed different responses (the response was complete in the four smaller keloids). The largest keloid needed 9 doses to achieve an improvement of 70%. In conclusion, combined treatment with 0.375 IU of bleomycin and 4mg of triamcinolone acetonide to 1 cm2 was considered to be an acceptable procedure for the treatment of keloids. The best results were obtained in keloids over 1 cm2 or when divided into 1 cm2 square areas. Larger series need to be performed in order to confirm these results.. 相似文献
90.
Antonio Rodríguez Valiente Carolina Pérez Sanz Carmen Górriz Adoración Juárez Marc Monfort José R. García Berrocal Juana Gil Fernández Rafael Ramírez Camacho 《Acta otorrinolaringologica espanola》2009,60(1):43-48
IntroductionMany presbycusic patients have difficulty in understanding certain words. This could be justified because certain sounds in Spanish are more difficult to perceive, particularly the sounds with energy in the high frequencies. We propose to use a sentence as a tool to check this theory.Materials and methodAll the Spanish sounds were analyzed, measuring the degree of acoustic energy in all the frequencies. The conclusions drawn from the comparison of the results allowed the design of the tool that is proposed here.ResultsWe established a gradient of perception difficulty, occlusive consonants being the least perceptible, followed by fricative, and finally all those segments with harmony and a clear formant structure. The Spanish sentence “Ana vio ese coche rojizo fino” is proposed as the tool for this study. This sentence has some as it comprises certain peculiarities that makes it particularly useful for this purpose. It will allow us to check whether understanding deteriorates as we move from beginning to end, helping evaluate the importance of high frequencies for intelligibility.ConclusionsA positive result could help in the design of amplification systems to improve speech intelligibility. In addition, the exploratory tool could allow neuro-acoustic exploration, useful in the central auditory pathology studies. 相似文献