全文获取类型
收费全文 | 386篇 |
免费 | 12篇 |
国内免费 | 11篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 1篇 |
基础医学 | 35篇 |
口腔科学 | 5篇 |
临床医学 | 29篇 |
内科学 | 88篇 |
皮肤病学 | 16篇 |
神经病学 | 12篇 |
特种医学 | 76篇 |
外科学 | 27篇 |
综合类 | 7篇 |
预防医学 | 16篇 |
眼科学 | 2篇 |
药学 | 49篇 |
2篇 | |
中国医学 | 2篇 |
肿瘤学 | 31篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 5篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2015年 | 6篇 |
2014年 | 13篇 |
2013年 | 9篇 |
2012年 | 5篇 |
2011年 | 10篇 |
2010年 | 12篇 |
2009年 | 9篇 |
2008年 | 8篇 |
2007年 | 14篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 11篇 |
2003年 | 5篇 |
2002年 | 8篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 8篇 |
1998年 | 20篇 |
1997年 | 17篇 |
1996年 | 15篇 |
1995年 | 11篇 |
1994年 | 14篇 |
1993年 | 10篇 |
1992年 | 7篇 |
1989年 | 13篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 12篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 1篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1964年 | 1篇 |
排序方式: 共有409条查询结果,搜索用时 78 毫秒
21.
M ODowd T Geoghegan PL Munk G McAuley WC Torreggiani 《Journal of Medical Imaging and Radiation Oncology》2006,50(4):386-388
Osseous haemophilic pseudotumours are uncommon. The commonest sites of involvement are the femur and the pelvis. Trauma is the initiating factor in most reported cases and repeated bleeding into the lesion contributes to their growth. Most lesions grow slowly and are often asymptomatic. Complications include massive haemorrhage, infection and pathological fracture. We present an extremely unusual presentation where a large haemophilic pseudotumour of the pelvis extended to impinge the adjacent colon, resulting in large bowel obstruction. 相似文献
22.
Dinsmore RC Calton WC Harvey SB Blaney MW 《Journal of the American College of Surgeons》2000,191(2):131-136
BACKGROUND: Polypropylene mesh (PPM) is an effective material for the repair of abdominal wall defects, but has a tendency to induce dense adhesions when in contact with viscera. Seprafilm (Genzyme Corp, Cambridge, MA), a bioresorbable membrane, has been shown to reduce adhesion formation after midline closures in humans and to PPM in animals. Given the increased inflammatory response expected with surgical trauma, its efficacy under surgical conditions has been questioned. STUDY DESIGN: A prospective, randomized, blinded study was conducted using a rabbit model. Standardized abdominal wall defects were created in three groups of New Zealand white rabbits. The cecum was deserosalized to simulate the effects of trauma. The abdominal defect was then repaired with PPM. In the control group, no Seprafilm was used. In the first experimental group Seprafilm was placed between the mesh and the abdominal viscera. In the second experimental group Seprafilm was placed over the deserosalized area and between the mesh and abdominal viscera. Animals were sacrificed at 30 days and adhesions were categorized and quantified using digital image analysis of inked specimens. The strength of incorporation was also determined. RESULTS: The formation of adhesions between the viscera and mesh repair was dramatically reduced in both experimental groups compared with the control group. The incidence of visceral adhesions was reduced by 80% in the single film group (p = 0.0004) and 90% in the double film group (p = 0.00008). The reduction in surface area of adhesions was 96.4% in the single film group (p = 0.000019) and 99.4% in the double film group (p = 0.00002). Omental adhesions were reduced by 30% but this did not achieve statistical significance. Strength of incorporation was not adversely affected in either group. CONCLUSIONS: Seprafilm is highly effective in preventing adhesions to PPM. This effect was not diminished by the presence of visceral trauma and its resultant inflammatory response. The use of Seprafilm does not adversely affect tissue incorporation. Clinical trials are warranted to determine if the protective effects of Seprafilm demonstrated in this study are applicable in the clinical setting. 相似文献
23.
Objective : To evaluate the efficacy of biliary‐enteric bypass in the palliation of malignant hilar biliary obstruction. Materials and Methods : Records of 19 patients from 1995 to 1998 were reviewed. There were 13 patients with cholangiocarcinoma and 6 patients with carcinoma of the gallbladder. Single biliary‐enteric bypass had been performed in 13 of the patients; the rest had more than one biliary‐enteric anastomosis. Results : The 30‐day mortality was 21% (4/19 patients). Bile leakage occurred in 2 patients, leading, in both, to fatality. Excluding the 30‐day mortality, the median survival of patients with carcinoma of the gallbladder and cholangiocarcinoma was 116 days (43–200) and 202 days (47–1207), respectively. The mean hospital stay was 31 days (13–59) and all patients were discharged with their symptoms relieved and a drop in bilirubin of at least two‐thirds their pre‐operative level. The late complication rate was 26.7% (4/15 patients). Conclusion : Biliary‐enteric bypass is effective in the palliation of symptoms of patients suffering from unresectable hilar biliary obstruction, although it carries considerable mortality and morbidity. Stenting, rather than surgery, should be considered for patients with unresectable gallbladder cancer. 相似文献
24.
A protein lethal to mice was isolated from the sea nettle (Chrysaora quinquecirrha) mesenteric tentacle nematocysts by immunochromatography. The partially purified protein was also toxic to spontaneously beating cultural chick cardiocytes but was not hemolytic to rat erythrocytes. On sodium dodecyl sulfate polyacrylamide gels, the mesenteric protein consisted of three bands with apparent molecular weights of 175,000, 160,000 and 108,000. The three protein bands yielded similar peptide maps when subjected to limited proteolysis. 相似文献
25.
T M?nsson H W Randle R M Mandojana G J Calton J W Burnett 《Acta dermato-venereologica》1985,65(1):72-75
Three patients exhibiting recurrent cutaneous eruptions induced by contact with jellyfish tentacles are presented. The recurrent eruptions appeared several days after the primary exposure without contact with any offending coelenterate. The principal species involved include Pelagia noctiluca, Physalia physalis and probably Lychnorhiza lucerna. These three cases, combined with an earlier similar report of recurrent lesions induced by Physalia physalis suggest that this phenomenon may be widespread. In two of the three cases, the secondary eruption was more severe than that occurring after the primary envenomation. 相似文献
26.
27.
Verapamil, a calcium antagonist, is effective in delaying death in mice after i.v. challenge with sea nettle (Chrysaora quinquecirrha) or Portuguese man-o'war (Physalia physalis) crude venom. Death caused by these venoms could also be delayed by prior medication of the animals. Continuous EKG monitoring of sea nettle venom-challenged rats demonstrated that a single rapid injection of verapamil might require 4 min to be effective and that up to four repeated injections may be necessary to counteract the venom-induced abnormalities. Verapamil reduced the sea nettle venom-induced positive inotropic effect on isolated guinea pig atrial strips. These data further indicate the effectiveness of verapamil as a therapeutic agent against jellyfish cardiotoxins. 相似文献
28.
Objective: To study the functional consequences of nutritional anemia by evaluating the exercise performance in these children.Methods: The study was conducted on 30 each of anemic and normal children of both sexes aged between 7 and 14 years. Relevant history
was taken, and detailed examination was done. These children were classified according to severity of anemia based on hemoglobin
estimation as mild (10–11.9 g/dl), moderate (7–9.9 g/dl) and normal (>12g/dl). Children with severe anemia (Hb <7g/dl), heart
disease, non-nutritional anemia, acute febrile or respiratory illness were excluded. The subjects were tested on Mortara X
Scribe colour stress treadmill using the modified Bruce protocol. Continuous computerised electrocardiographic analysis was
done. The parameters studied included heart rate, systolic blood pressure, double product (DP = HRxSBP), ECG changes, metabolic
equivalents (METS) and exercise duration. The end point of the test was a HR of 170/min (non-fatigue group) or inability to
perform further (fatigue group). Statistical analysis was done by appropriate tests.Results: Fifteen children each with mild and moderate anemia and 30 age-matched controls were enrolled in the study. There was no
significant difference in the resting HR, exercise duration or DP between the cases and controls. Thirty-one children reached
the target HR (non-fatigue group). The end-point HR was significantly lesser among the anemic children in the fatigue group
(P 0.04). The percent gain of SBP, at peak exercise (P 0.0007) and recovery SBP as percent of resting SBP (p 0.006) were significantly
more in the anemic children, more so in the mildly anemic ones. Lesser METS was achieved by anemics as compared to controls
(P 0.04). ECG changes occurred significantly more often in anemic children, 53.8% of those with changes being moderately anemic,
the main abnormality being ST depression. None developed arrhythmia during exercise testing.Conclusion: The cardiovascular response to physical exercise is compromised in children with nutritional anemia and hence these children
may never attain their full potential in various school activities. Prevention of anemia should be a priority in school going
children 相似文献
29.
Background
There are multiple studies in different countries regarding the prevalence of vitamin D deficiency. These studies showed high prevalence of vitamin D deficiency in Asian countries. This study tries to elucidate the prevalence of vitamin D deficiency and its influencing factors in population of Tehran.Methods
1210 subjects 20–64 years old were randomly selected. 25 (OH) D serum levels were measured. Duration of exposure to sunlight, the type of clothing and level of calcium intake and BMI were quantified based on a questionnaire.Results
A high percentage of vitamin D deficiency was defined in the study population. Prevalence of severe, moderate and mild Vitamin D deficiency was 9.5%, 57.6% and 14.2% respectively. Vitamin D serum levels had no significant statistical relation with the duration of exposure to sunlight, kind of clothing and BMI. Calcium intake in the normal vitamin D group was significantly higher than the other groups (714.67 ± 330.8 mg/day vs 503.39 ± 303.1, 577.93 ± 304.9,595.84 ± 313.6). Vitamin D serum levels in young and middle aged females were significantly lower than the older group.Conclusions
Vitamin D deficiency has a high prevalence in Tehran. In order to avoid complications of vitamin D deficiency, supplemental dietary intake seems essential. 相似文献30.