Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis

Neurological Sciences - Anti-seizure drugs have long been known to affect thyroid hormone levels in epilepsy patients. The current study is a network meta-analysis designed to produce a systematic...     

Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia

Neurological Sciences - We aim to investigate blood–brain barrier (BBB) dysfunction and myelin basic protein (MBP) in amyotrophic lateral sclerosis (ALS) with or without frontotemporal...     

改良张力支具对肱骨髁间骨折患者术后功能康复的临床效果评价

目的探讨改良张力支具对肱骨髁间骨折患者术后功能康复的临床效果评价。 方法回顾性分析本院采用切开复位内固定术治疗的40例肱骨髁间骨折患者的资料。单纯采用普通固定支具进行功能锻炼的为对照组（21例）,采用改良张力支具进行功能锻炼的为观察组（19例）。比较两组患者术后去除支具和末次随访时肘关节屈曲度、肘关节背伸度、前臂旋前度、前臂旋后度和Mayo肘关节功能评分,以评定改良张力支具的疗效。 结果所有患者术后均获得随访,平均随访13.79个月。观察组与对照组相比,术后去除支具时肘关节屈伸活动度[（104.47±12.37）° vs.（88.85±8.10）°,P<0.001],差异有统计学意义;肘关节旋转活动度[（140.31±16.87）° vs.（135.66±12.86）°,P=0.331],差异无统计学意义;肘关节Mayo评分[（78.84±5.04）分vs.（73.80±4.46）分,P=0.002],差异有统计学意义。末次随访时肘关节屈伸活动度[（107.52±12.30）° vs.（93.00±8.47）°,P<0.001],差异有统计学意义;肘关节旋转活动度[（141.42±17.02）° vs.（137.19±12.80）°,P=0.37],差异无统计学意义;肘关节Mayo评分[（80.15±5.24）分vs.（74.95±4.18）分,P=0.001],差异有统计学意义。 结论术后使用改良张力支具可以改善肱骨髁间骨折患者的屈伸活动度和肘关节功能。     

Association Between Lipid Profiles and Left Ventricular Hypertrophy: New Evidence from a Retrospective Study

ObjectiveTo explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population.MethodsWe conducted a retrospective observational study to investigate the relationship between lipid markers [including triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL-cholesterol, apolipoprotein A-I, apolipoprotein B, lipoprotein[a], and composite lipid profiles] and left ventricular hypertrophy. A total of 309,400 participants of two populations (one from Beijing and another from nationwide) who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study. 7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy. Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the interventricular septum or left ventricle posterior wall > 11 mm. The Logistic regression model was used in the cross-sectional study. Cox model and Cox model with restricted cubic splines were used in the longitudinal cohort.ResultsIn the cross-sectional study, for participants in the highest tertile of each lipid marker compared to the respective lowest, triglycerides [odds ratio (OR): 1.250, 95%CI: 1.060 to 1.474], HDL-cholesterol (OR: 0.780, 95%CI: 0.662 to 0.918), and lipoprotein(a) (OR: 1.311, 95%CI: 1.115 to 1.541) had an association with left ventricular hypertrophy. In the longitudinal cohort, for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest, triglycerides [hazard ratio (HR): 3.277, 95%CI: 1.720 to 6.244], HDL-cholesterol (HR: 0.516, 95%CI: 0.283 to 0.940), non-HDL-cholesterol (HR: 2.309, 95%CI: 1.296 to 4.112), apolipoprotein B (HR: 2.244, 95%CI: 1.251 to 4.032) showed an association with new-onset left ventricular hypertrophy. In the Cox model with forward stepwise selection, triglycerides were the only lipid markers entered into the final model.ConclusionLipids levels, especially triglycerides, are associated with left ventricular hypertrophy. Controlling triglycerides level potentiate to be a strategy in harnessing cardiac remodeling but deserve to be further investigated.     

颈部血管四维重建:Ⅱ.超声图像采集及软件处理

目的编制出合理的软件程序,对颈动脉系列截面图进行三维超声重建.方法用自行研制的机械臂及软件系统采集颈动脉图像并进行数字化处理,再用计算机图形学方法重建出血管三维图像.结果应用三维图形库OpenGL绘制出具有真实感的三维血管表面图像并进行定量测定.结论该软件系统简单、合理、便于操作,可完成血管等距横断面图像的三维重建.     

Tetralogy of Fallot Cardiac Function Evaluation and Intelligent Diagnosis Based on Dual‐Source Computed Tomography Cardiac Images

Tetralogy of Fallot (TOF) is the most common complex congenital heart disease (CHD) of the cyanotic type. Studies on ventricular functions have received an increasing amount of attention as the development of diagnosis and treatment technology for CHD continues to advance. Reasonable options for imaging examination and accurate assessment of preoperative and postoperative left ventricular functions of TOF patients are important in improving the cure rate of TOF radical operation, therapeutic evaluation, and judgment prognosis. Therefore, with the aid of dual‐source computed tomography (DSCT), cardiac images with high temporal resolution and high definition, we measured the left ventricular time–volume curve using image data and calculating the left ventricular function parameters to conduct the preliminary evaluation on TOF patients. To comprehensively evaluate the cardiac function, the segmental ventricular wall function parameters were measured, and the measurement results were mapped to a bull's eye diagram to realize the standardization of segmental ventricular wall function evaluation. Finally, we introduced a new clustering method based on auto‐regression model parameters and combined this method with Euclidean distance measurements to establish an intelligent diagnosis of TOF. The results of this experiment show that the TOF evaluation and the intelligent diagnostic methods proposed in this article are feasible.