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101.
102.
AIMS: To determine whether nebulised budesonide improves the symptoms or shortens the duration of stay of children admitted to hospital with a clinical diagnosis of croup. METHODS: A prospective, randomised, double blind placebo controlled trial. Patients received either nebulised budesonide or placebo every 12 hours. The main outcome measures were duration of inpatient stay and croup scores at 30 minutes, one, two, four, 12, and 24 hours. RESULTS: 87 patients (89 admissions) aged 7-116 months entered the trial. Nebulised budesonide was associated with a significant improvement in symptoms at 12 hours (95% confidence interval (CI) 1 to 3) and 24 hours (95% CI 0 to 3). Patients with an initial croup score above 3 demonstrated a significant improvement in symptoms at two hours (95% CI 1 to 3). Nebulised budesonide was also associated with a 33% reduction in the length of stay (95% CI 2% to 63%) when the confounding variables of age, initial croup score, and coryzal symptoms were taken into consideration. CONCLUSIONS: Nebulised budesonide is an effective treatment for children admitted to hospital with a clinical diagnosis of croup. 相似文献
103.
YL Lau LCK Low R Yung KW Ng CW Leung WH Lee A Ho SJ Oppenheimer Hong Kong Hib Study Group 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(2):173-176
A 5-year territory-wide retrospective survey of invasive Haemophilus influenzae type b diseases was conducted in Hong Kong. Between 1986 and 1990, 57 cases (28 male) were recorded in children less than 12 years old (37 cases of meningitis, 9 of septicaemia and 11 of bacteraemic pneumonia). The annual incidence for children less than 5 years old was 2.7 per 105 (95% confidence interval (CI) 2.0–3.5). Of the 57 cases, 39 were Chinese and 18 non-Chinese (7 Vietnamese refugees, 6 Caucasians, 5 others). The annual incidence in Vietnamese refugees less than 5 years old was 42.7 per 105 (95% CI 17.2–87.9), giving a relative risk of 18.5 (95% CI 8.3–41.0). Chinese patients (68%) were under-represented as Chinese accounted for at least 94% of the population. Moreover, 14 of the 39 Chinese patients had pre-existing medical problems, compared with only 1 of the 18 non-Chinese patients (p = 0.022). 相似文献
104.
Properties of immobilized guinea pig hindlimb muscles 总被引:1,自引:0,他引:1
Maier A; Crockett JL; Simpson DR; Saubert CW IV; Edgerton VR 《The American journal of physiology》1976,231(5):1520-1526
105.
106.
Controlled ovarian hyperstimulation and intrauterine insemination for treating male subfertility: a controlled study 总被引:5,自引:10,他引:5
Cohlen BJ; te Velde ER; van Kooij RJ; Looman CW; Habbema JD 《Human reproduction (Oxford, England)》1998,13(6):1553-1558
In this randomized crossover trial we investigated whether the use of
controlled ovarian hyperstimulation with low-dose human menopausal
gonadotrophin in couples with male subfertility leads to a higher
probability of conception when intrauterine insemination (IUI) is applied.
We also investigated whether the efficacy of IUI in natural or stimulated
cycles was related to the severity of male subfertility. Seventy-four
couples completed 308 treatment cycles. Thirteen pregnancies occurred after
IUI in a natural cycle (pregnancy rate per completed cycle: 8.4%) and 21
after IUI in a stimulated cycle (pregnancy rate per completed cycle:
13.7%). The difference between the two treatment modalities was not
statistically significant. The efficacy of IUI in stimulated cycles was
related to the severity of the semen defect. In couples with a total motile
sperm count < 10 x 10(6), ovarian stimulation did not improve treatment
outcome, while it did in couples with a total motile sperm count > or =
10 x 10(6). Compared with the expected chance of conceiving spontaneously
without treatment, both natural and stimulated cycles improved the
probability of conception. We conclude that, for the group as a whole,
ovarian stimulation did not improve the probability of conception. However,
in couples with less severe semen defects, ovarian stimulation did improve
the probability of conception.
相似文献
107.
108.
109.
Angels Natividad Graham Cooke Martin J Holland Matthew J Burton Hassan M Joof Kirk Rockett Dominic P Kwiatkowski David CW Mabey Robin L Bailey 《BMC medical genetics》2006,7(1):40-6
Background
Trachoma, an infectious disease of the conjunctiva caused by Chlamydia trachomatis, is an important global cause of blindness. A dysregulated extracellular matrix (ECM) proteolysis during the processes of tissue repair following infection and inflammation are thought to play a key role in the development of fibrotic sequelae of infection, which ultimately leads to blindness. Expression and activity of matrix metalloproteinase 9 (MMP-9), a major effector of ECM turnover, is up-regulated in the inflamed conjunctiva of trachoma subjects. Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions. 相似文献110.
Autoregulation of blood flow in the rat kidney 总被引:4,自引:0,他引:4