全文获取类型
收费全文 | 75369篇 |
免费 | 7703篇 |
国内免费 | 5097篇 |
专业分类
耳鼻咽喉 | 742篇 |
儿科学 | 999篇 |
妇产科学 | 619篇 |
基础医学 | 6242篇 |
口腔科学 | 1111篇 |
临床医学 | 8499篇 |
内科学 | 8504篇 |
皮肤病学 | 775篇 |
神经病学 | 2905篇 |
特种医学 | 3010篇 |
外国民族医学 | 14篇 |
外科学 | 7593篇 |
综合类 | 18266篇 |
现状与发展 | 14篇 |
预防医学 | 7195篇 |
眼科学 | 1229篇 |
药学 | 8643篇 |
92篇 | |
中国医学 | 6875篇 |
肿瘤学 | 4842篇 |
出版年
2024年 | 321篇 |
2023年 | 996篇 |
2022年 | 2209篇 |
2021年 | 3046篇 |
2020年 | 2600篇 |
2019年 | 1846篇 |
2018年 | 1935篇 |
2017年 | 2264篇 |
2016年 | 1976篇 |
2015年 | 3115篇 |
2014年 | 4002篇 |
2013年 | 4660篇 |
2012年 | 6392篇 |
2011年 | 7063篇 |
2010年 | 5903篇 |
2009年 | 5156篇 |
2008年 | 5563篇 |
2007年 | 5248篇 |
2006年 | 4797篇 |
2005年 | 3901篇 |
2004年 | 3148篇 |
2003年 | 2938篇 |
2002年 | 2510篇 |
2001年 | 1874篇 |
2000年 | 1389篇 |
1999年 | 792篇 |
1998年 | 432篇 |
1997年 | 405篇 |
1996年 | 313篇 |
1995年 | 271篇 |
1994年 | 247篇 |
1993年 | 151篇 |
1992年 | 105篇 |
1991年 | 131篇 |
1990年 | 82篇 |
1989年 | 67篇 |
1988年 | 58篇 |
1987年 | 43篇 |
1986年 | 42篇 |
1985年 | 44篇 |
1984年 | 26篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1980年 | 11篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1976年 | 12篇 |
1975年 | 6篇 |
1974年 | 8篇 |
1968年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
31.
角膜碱烧伤房水一氧化氮及一氧化氮合酶变化 总被引:3,自引:2,他引:1
目的探讨角膜碱烧伤后房水一氧化氮(NO)与炎症反应的关系。方法用健康家兔动态观察对照组、实验组和对侧眼组眼内炎症反应及房水一氧化氮合酶(NOS)和NO2^-/NO3^-的活性。结果角膜碱烧伤后炎症反应与房水NOS和NO活性呈动态变化,实验组明显高于对侧眼组,且两组均高于对照组。结论房水NO的变化与角膜碱烧伤后的眼内炎症反应密切相关。 相似文献
32.
旋毛虫病在东南欧的巴尔干半岛及临近国家的流行现状各不相同,在保加利亚、塞尔维亚和黑山、罗马尼亚及克罗地亚,猪和人的旋毛虫感染率均较高;在波斯尼亚和黑塞哥维那则具有中度的旋毛虫感染率;在匈牙利已有多年未发现人体旋毛虫病,但近2年来已发现了散发的猪旋毛虫病。旋毛虫病在东南欧国家的再度肆虐,提示旋毛虫病能够突破食品安全体系和兽医检疫的薄弱环节,从而可导致地区性、全国性甚至国际性的旋毛虫病扩散。该文对旋毛虫病在东南欧国家的历史、分布、流行现状、感染来源、虫种及再度肆虐的原因等进行了综述。 相似文献
33.
用放射配体结合分析法分别测定了正常组、特布他林组、特布他林十曲尼司特组豚鼠的肺组织β受体最大结合力和解离常数,结果显示:给特布他林后豚鼠肺组织β受体发生明显的向下调节.曲尼司特可预防此向下调节的发生. 相似文献
34.
Ming Zhao Cheng Simon C F Rawlinson Andrew A Pitsillides Gul Zaman Subburaman Mohan David J Baylink Lance E Lanyon 《Journal of bone and mineral research》2002,17(4):593-602
The mechanism by which mechanical strain and estrogen stimulate bone cell proliferation was investigated using monolayer cultures of human osteoblastic TE85 cells and female human primary (first-passage) osteoblasts (fHOBs). Both cell types showed small but statistically significant dose-dependent increases in [3H]thymidine incorporation in response to 17beta-estradiol and to a single 10-minute period of uniaxial cyclic strain (1 Hz). In both cell types, the peak response to 17beta-estradiol occurred at 10(-8) - 10(-7) M and the peak response to strain occurred at 3500 microstrain ((mu)epsilon). Both strain-related and 17beta-estradiol-related increases in [3H]thymidine incorporation were abolished by the estrogen receptor (ER) modulator ICI 182,780 (10-8 M). Tamoxifen (10(-9) - 10(-8) M) increased [3H]thymidine incorporation in both cell types but had no effect on their response to strain. In TE85 cells, tamoxifen reduced the increase in [3H]thymidine incorporation associated with 17beta-estradiol to that of tamoxifen alone but had no such effect in fHOBs. In TE85 cells, strain increased medium concentrations of insulin-like growth factor (IGF) II but not IGF-I, whereas 17beta-estradiol increased medium concentrations of IGF-I but not IGF-II. Neutralizing monoclonal antibody (MNAb) to IGF-I (3 microg/ml) blocked the effects of 17beta-estradiol and exogenous truncated IGF-I (tIGF-I; 50 ng/ml) but not those of strain or tIGF-II (50 ng/ml). Neutralizing antibody to IGF-II (3 microg/ml) blocked the effects of strain and tIGF-II but not those of 17beta-estradiol or tIGF-I. MAb aIR-3 (100 ng/ml) to the IGF-I receptor blocked the effects on [3H]thymidine incorporation of strain, tIGF-II, 17beta-estradiol, and tIGF-I. HOBs and TE85 cells, act similarly to rat primary osteoblasts and ROS 17/2.8 cells in their dose-related proliferative responses to strain and 17beta-estradiol, both of which can be blocked by the ER modulator ICI 182,780. In TE85 cells (as in rat primaries and ROS 17/2.8 cells), the response to 17beta-estradiol is mediated by IGF-I, and the response to strain is mediated by IGF-II. Human cells differ from rat cells in that tamoxifen does not block their response to strain and reduces the response to 17beta-estradiol in TE85s but not primaries. In both human cell types (unlike rat cells) the effects of strain and IGF-II as well as estradiol and IGF-I can be blocked at the IGF-I receptor. 相似文献
35.
HCC的早期诊断是其治疗的关键,HCC血清标志物的检测又为其诊断提供了有利的途径,并且操作简单,敏感性高和特异性强。目前常用的血清标志物为AFP、AFP变异体、AFP mRNA、AFU、GGT、DCP、AIF、GPC3等。这些标志物的联合使用有助于HCC的诊断及预后。 相似文献
36.
目的:探讨甲状腺全切除术在治疗分化性甲状腺癌中的临床应用价值。方法:采用我院1988年1月~2001年5月甲状腺全切除术或甲状腺侧叶切除加峡部切除术治疗分化性甲状腺癌125例,对其手术并发症发生、局部复发、转移情况及术后5年生存率进行回顾性对比分析。结果:甲状腺全切除术术后并发症发生率高于甲状腺侧叶切除加峡部切除术组;局部复发、转移率低于侧叶切除加峡部切除术组;5年生存率两组无显著性差异。结论:甲状腺全切除术是治疗甲状腺癌有效的手术方式,但应掌握手术指征,改进、提高手术技术,减少并发症。 相似文献
37.
目的:采用几种不同类型的炎症动物模型对AGE的抗炎作用进行研究。方法:大鼠角叉菜胶性足肿胀,醋酸诱导的小鼠腹腔毛细血管通透性增高,小鼠羧甲基纤维素囊中的白细胞数目,大鼠巴豆油性气囊肿的形成。结果:连续灌胃给药5天,AGE(5、10g/kg)可以显著抑制角叉菜胶所致的大鼠足肿胀、醋酸所致的小鼠腹腔毛细血管通透性增高、小鼠羧甲基纤维素囊中白细胞的游出数目以及大鼠巴豆油性气囊的形成。结论:藤茶提取物具有显著的抗炎活性。 相似文献
38.
39.
Objective To test the hypothesis that p53 gene therapy combined with endostatin can enhance tumor response to radiation therapy of RM-1 mouse xenograft prostate cancer and to investigate its mechanism. Methods A mouse prostate cancer model was established. Then mice with xenograft tumor were randomly divided into group A (control), B (radiation), C (radiation and rAdp53), D (radiation and rh-endostatin) and E (radiation and rAdp53 and rh-endostatin). On day 1, rAdp53 was injected intra-tumorously with 1 × 1010 vp per animal to group C and E. From day 1 to 14, rh-endostatin was given 15 mg/kg intraperitoneally daily to group D and E. On day 4 single fraction of 15 Gy was given to tumors in groups B, C, D and E. Normal saline was injected intra-tumorously or intraperitoneaUy accordingly as control. No treatment was done to group A. Tumor volume was measured daily. Samples were collected on Days 5, 10 and 15. Ki67, CD31, p53 and VEGF were detected by means of immunohistochemistry. Results (1) Radiation alone, radiation combined with intra-tumorous injection of Adp53 and/or intraperitoneal injection of rh-endostatin resulted in tumor growth arrest of RM-1 cells in vivo (P = 0.000). Radiation combined with both rAdp53 and rh-endostatin was the most effective treatment (P < 0.05). (2) All the four treatment groups had a decreased expression of mutant type P53 (P = 0.000). The expression of Ki67 in groups B and C were equal (P 0.05) and increasing (P = 0.000), respectively. Group D had a up-down-up curve (P < 0.05), but group E had a up-down one. On day 5 the expresion of VEGF in group E was the lowest (P < 0.05). An increased expression of MVD compared with the control was shown, and MVD in groups C, D and E were always higher than that in the control (P < 0.05). Conclusions The limitation of radiotherapy could be overcome by combination with beth p53 gene therapy and endostatin on the growth of mouse prostate cancer cell. Radiation, rAdp53 and endostatin have their own role but they can be interacted with each other. 相似文献
40.
氟尿嘧啶化放疗的现状与未来 总被引:1,自引:0,他引:1
20世纪60年代在肿瘤的根治和辅助治疗中就使用了氟尿嘧啶(Fluorouracil,FU)化放疗(外放疗同时进行化疗)。2002年.全世界约200万肿瘤患者接受了FU治疗.其中很大一部分是以FU为基础的化放疗。FU是许多肿瘤患者的基础治疗药物。总之,FU化放疗显著改善了肿瘤的局部控制.并提高了部分肿瘤患者的生存率:也提高了部分具有重要功能的器官的保留。 相似文献