HIV-associated Hodgkin lymphoma during the first months on combination antiretroviral therapy

Hodgkin lymphoma (HL) incidence with HIV infection may have increased with the introduction of combination antiretroviral therapy (cART), suggesting that immune reconstitution may contribute to some cases. We evaluated HL risk with cART during the first months of treatment. With 187 HL cases among 64 368 HIV patients in France, relative rates (RRs) and 95% confidence intervals (CIs) of HL were estimated using Poisson models for duration of cART, CD4 count, and HIV load, with and without adjustment for demographic/clinical covariates. HL risk was unrelated to cART use overall, but it was related to time intervals after cART initiation (P = .006). Risk was especially and significantly elevated in months 1-3 on cART (RR 2.95, CI 1.64-5.31), lower in months 4-6 (RR 1.63), and null with longer use (RR 1.00). CD4 count was strongly associated with HL risk (P < 10??), with the highest HL incidence at 50-99 CD4 cells/mm3. With adjustment for CD4 count and covariates, HL risk was elevated, but not significantly (RR 1.42), in months 1-3 on cART. HIV load had no added effect. HL risk increased significantly soon after cART initiation, which was largely explained by the CD4 count. Further studies of HIV-associated HL are needed.     

炎琥宁原料药HPLC含量测定方法研究

目的建立炎琥宁原料药HPLC含量测定方法。方法采用Lnertsil ODS-3柱(5μm 250×4.6mm),乙腈—磷酸盐缓冲液45:55为流动相,检测波长251nm。结果炎琥宁在50～500μg范围内线性关系良好,相关系数为0.99997。平均回收率为99.39%(RSD为0.4)。结论本法简便、准确、灵敏度高、重现性好,可用于炎琥宁的质量控制。     

Long-term nonprogressors and elite controllers in the ANRS CO5 HIV-2 cohort

Among 342 HIV-2-infected patients of the ANRS CO5 HIV-2 cohort, the prevalence of long-term nonprogressors (LTNPs) (i.e. asymptomatic for at least 8 years while maintaining CD4 cell count at least 500 cells/μl) and of HIV controllers (i.e. controlling HIV replication in the absence of antiretroviral treatment for at least 10 years) was 6.1% (95% confidence interval 3.9-9.1) and 9.1% (6.3-12.7), respectively. Most LTNPs (81%) were HIV controllers, whereas only 55% of HIV controllers were LTNPs.     

影响乳糖酸阿奇霉素效价因素分析

目的为提高乳糖酸阿奇霉素的效价指标,从而提高该产品质量。通过实验研究成盐反应过程各种参数对乳糖酸阿奇霉素效价的影响选择出最佳工艺条件,如控制成盐温度、终点PH值和反应时间,控制制备乳糖酸的PH值等工艺参数。用于指导大生产,使大生产中乳糖酸阿奇霉素的效价有很大的提高,提高了质量。经大生产实践,实验获得的工艺条件是最佳效价控制条件,达到了提高效价的目的。     

应用全粉末压片解决西咪替丁溶出度

目的：针对药品的特性及压片工艺,效果的不同,得出最佳片剂压片的方法。方法：采用全粉末压片方法的分析,结果：该方法压片快,合格率高,结果：全粉末压片法解决西味替丁崩解速度快．合格率100％。