植物神经癫痫52例脑电图分析

报道52倒6个类型植物神经癫痫,重点分析了脑电图的变化,脑电图异常率100％,69.4％的病例出现两侧阵发性4～7Hzθ节律及6和14Hz阳性棘波,提示中线深部有功能紊乱,亦支持丘脑及脑干部有病变。此外蝶骨电极能提高脑电图对本病的阳性诊断率,值得采用。本文证明脑电图对植物神经性癫痫与非癫痫的鉴别诊断,具有肯定的价值。     

在医疗纠纷案件中医疗机构应注意的问题

我们广大医疗机构,特别是三级甲等医院承担着繁重的医疗、保健和防疫等任务,许多医务人员是满负荷甚至超负荷地工作,出个把失误在所难免,作为法官,我个人对这些都能理解,但是作为患者,疾病对于他们来讲就是一件大事,有些甚至是天塌下来的事。他们抱着对医疗机构、医生的信任前来就医,把自己的生命健康交到医生手上,如果因为医生的疏忽导致不良损害的发生,对这个患者来说,就是100%,不仅造成患者本身的痛苦和伤害,还可能会对患者家庭、甚至社会造成损害,所以必须最大限度地避免由于我们的问题造成患者的不良损害的发生。     

A systematic review of outcomes assessed in randomized controlled trials of surgical interventions for carpal tunnel syndrome using the International Classification of Functioning, Disability and Health (ICF) as a reference tool

Background  

A wide range of outcomes have been assessed in trials of interventions for carpal tunnel syndrome (CTS), however there appears to be little consensus on what constitutes the most relevant outcomes. The purpose of this systematic review was to identify the outcomes assessed in randomized clinical trials of surgical interventions for CTS and to compare these to the concepts contained in the International Classification of Functioning, Disability and Health (ICF).     

移动式数字X线机应用前景展望

移动式X线机实现了影像信息的数字化采集、存储、调阅、检查报告的生成、审核、查询和输出等功能,从满足突发公共卫生事件的应急需要和卫生防疫的需要来展望,其市场应用前景看好.     

Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy.

To evaluate the possibility of radionuclide gene therapy and imaging in hepatocellular carcinoma cancer, we investigated the iodine accumulation of a human hepatocellular carcinoma cell line, SK-Hep1, by transfer of human sodium iodide symporter (hNIS) gene. By targeting NIS expression in SK-Hep1, we could also investigate whether these cells concentrate 99mTc-pertechnetate and 188Re-perrhenate as well as 125I in vitro and in vivo. METHODS: The hNIS gene was transfected to human hepatocellular carcinoma SK-Hep1 cell lines using lipofectamine plus reagent. The uptake and efflux of 125I, 99mTc-pertechnetate, and 188Re-perrhenate were measured in the transfected and parental cells. Biodistribution was studied in nude mice bearing SK-Hep1 and SK-Hep1-NIS at 10 and 30 min and at 1, 2, 6, 16, and 23 h after injection of 125I, 99mTc- pertechnetate, or 188Re-perrhenate. In tumor imaging studies, the nude mice were intravenously injected with 188Re-perrhenate and imaged with a gamma-camera equipped with a pinhole collimator at 30 and 60 min after injection. The survival rate (%) was determined by the clonogenic assay after 37 MBq/10 mL (1 mCi/10 mL) 131I and 188Re-perrhenate treatment. RESULTS: SK-Hep1-NIS, stably expressing the NIS gene, accumulated 125I up 150 times higher than that of SK-Hep1. Iodine uptake of SK-Hep1-NIS is completely blocked by perchlorate. NIS gene transfection into SK-Hep1 also resulted in 112- and 87-fold increases of 99mTc-pertechnetate and 188Re-perrhenate uptake, respectively. Iodide efflux from SK-Hep1-NIS was relatively slow, with only 10% released during the initial 5 min, and 60% remained at 25 min. In the biodistribution study using SK-Hep1-NIS-xenographed mice, the tumor uptake of 125I, 188Re-perrhenate, and 99mTc-pertechnetate was 68.0 +/- 15.0, 46.2 +/- 9.1, and 59.6 +/- 16.2 %ID/g (percentage injected dose per gram) at 2 h after injection, respectively. After 188Re-perrhenate injection in SK-Hep1 and SK-Hep1-NIS-xenographed nude mice, whole-body images clearly visualized the SK-Hep1-NIS tumor, whereas the control tumor was not visualized. The survival rate (%) of SK-Hep1-NIS was markedly reduced to 46.3% +/- 10.1% and 28.9% +/- 5.2% after 37 MBq/mL (1 mCi/10 mL) 131I and 188Re-perrhenate treatment compared with the survival rates of the parental cells. These results demonstrated that SK-Hep1-NIS could be selectively killed by the induced 131I and 188Re-perrhenate accumulation through NIS gene expression. CONCLUSION: NIS-based gene therapy using beta-emitting radionuclides has the potential to be used in hepatocellular carcinoma management.     

血浆置换床边治疗重型肝炎临床观察

目的探讨血浆置换(简称PE)床边治疗重型肝炎的临床疗效。方法60例病例采用常规内科治疗加PE治疗,比较PE治疗前后临床症状缓解时间及血生化变化。结果临床症状缓解迅速,黄疸减退,白蛋白、胆碱脂酶升高,PT恢复,补体上升,不影响肾功及电解质。结论PE为重型肝炎一种行之有效的治疗方法。     

先天性后侧半椎体切除术治疗角形脊柱后凸畸形

目的探讨先天性后侧半椎体切除术治疗角形脊柱后凸畸形的适应证、手术方法及临床效果. 方法采用该方法手术治疗角形脊柱后凸25例,经后路暴露双侧椎板,自双侧分离暴露关节突外侧和横突, 切除横突.沿椎弓根自骨膜下向前分离, 暴露多余的半椎体, 切除多余的一节椎弓和后侧半椎体,自后路行双侧弓根螺钉加压棍固定. 结果本组无脊髓损伤、感染等术后并发症发生.20例随访5～10年, 远期效果好; 3例随访1年以上, 矫正效果良好; 2例术后尚未及1年, 正在随访中.Cobb's角从术前平均68°降至术后平均11°. 结论先天性后侧半椎体切除术的年龄范围为8～22岁,年龄越大越趋向于作全脊柱截骨术.     

Management of congenital tracheal stenosis

Objectives: Congenital tracheal stenosis is a rare disease. Various methods for treatment exist but there is still much debate as to the appropriate surgical procedure. We present our surgical experiences of patch tracheoplasty and slide tracheoplasty as viable methods for the treatment of congenital tracheal stenosis. Methods: From 1994 to 2002, 13 patients were diagnosed with congenital tracheal stenosis. Eight patients (7 symptomatic and 1 asymptomatic) had their stenosis corrected, three by means of pericardial patch tracheoplasty, four by slide tracheoplasty, and one by resection and anastomosis. Concomitant operations were performed on six patients to treat congenital cardiovascular disease. Five patients showing no significant symptoms did not undergo tracheal surgery and received only cardiac procedures. A retrospective review of the hospital course, complications, and long-term results was conducted. Results: Among the patch tracheoplasty group, every patient suffered from granulation tissue formation. One patient died of respiratory acidosis and one was hospitalized due to recurrent granulation tissue, which required frequent bronchoscopy. The third patient from this group is free of all symptoms. Among the slide tracheoplasty group, one patient died of anastomosis disruption. The three remaining patients are alive and well. The one patient who received resection and anastomosis is alive without symptoms. Conclusions: Surgical repair of long-segment congenital tracheal stenosis exhibited high mortality and morbidity rates. Every patient that underwent pericardial patch tracheoplasty suffered from troublesome granulation tissue. As slide tracheoplasty provided relatively good results in the short and mid-term follow-up periods, it seems to be a preferred method for the treatment of long-segment congenital tracheal stenosis.     

Clinical assessment and management of depression.

Major depressive disorder is a psychiatric disorder that encompasses a broad range of emotional, psychological, behavioral, and physical symptoms (Fava et al., 2004). The nurse in the hospital, office, school, or community setting can provide the essential elements of effective care for depression, including early detection by screening, medication teaching, depression education, teaching coping skills, and appropriate use of specialists and resources. Utilizing the nursing process, the nurse can provide comprehensive care to improve the depressed patient's physical and psychological well-being.