全文获取类型
收费全文 | 754篇 |
免费 | 101篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 12篇 |
妇产科学 | 6篇 |
基础医学 | 69篇 |
口腔科学 | 6篇 |
临床医学 | 132篇 |
内科学 | 124篇 |
皮肤病学 | 18篇 |
神经病学 | 92篇 |
特种医学 | 113篇 |
外科学 | 70篇 |
综合类 | 11篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 72篇 |
眼科学 | 2篇 |
药学 | 82篇 |
肿瘤学 | 49篇 |
出版年
2024年 | 4篇 |
2023年 | 26篇 |
2022年 | 9篇 |
2021年 | 9篇 |
2020年 | 19篇 |
2019年 | 8篇 |
2018年 | 19篇 |
2017年 | 22篇 |
2016年 | 23篇 |
2015年 | 13篇 |
2014年 | 28篇 |
2013年 | 21篇 |
2012年 | 27篇 |
2011年 | 31篇 |
2010年 | 31篇 |
2009年 | 23篇 |
2008年 | 35篇 |
2007年 | 36篇 |
2006年 | 29篇 |
2005年 | 29篇 |
2004年 | 22篇 |
2003年 | 18篇 |
2002年 | 23篇 |
2001年 | 21篇 |
2000年 | 16篇 |
1999年 | 18篇 |
1998年 | 23篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 13篇 |
1994年 | 24篇 |
1993年 | 13篇 |
1992年 | 16篇 |
1991年 | 19篇 |
1990年 | 13篇 |
1989年 | 28篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 13篇 |
1985年 | 11篇 |
1984年 | 17篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1975年 | 6篇 |
1969年 | 3篇 |
排序方式: 共有865条查询结果,搜索用时 210 毫秒
91.
92.
Meryl Brod David Cobden Morten Lammert Donald Bushnell Philip Raskin 《Health and quality of life outcomes》2007,5(1):8
Background
Successfully managing diabetes is a complex process that includes addressing issues of drug efficacy, safety and treatment satisfaction. Additionally, the combined impact of patient/disease characteristics and treatment outcomes on treatment satisfaction is not well understood. The purpose of this study was to examine the impact of age, weight, gender, co-morbid conditions, diabetes history, treatment burden, efficacy (HbA1c) and side effects (weight gain, hypoglycemic events) on patients' appraisal of treatment satisfaction using linear regression models. 相似文献93.
M Blessmann Weber† LG Sponchiado de Ávila‡ R Albaneze‡ OL Magalhães de Oliveira§¶ BD Sudhaus¶ T Ferreira Cestari§ 《Journal of the European Academy of Dermatology and Venereology》2002,16(5):463-468
BACKGROUND: The aetiology of pityriasis alba (PA), a common dermatosis in childhood, is still controversial. The objective of this study was to assess the possible aetiopathogenic factors of this disease in infants. METHODS: Forty-four patients with PA and 31 healthy children were examined and compared. Personal hygiene habits, sun exposure, presence of Staphylococcus aureus in nasal fossae and presence of major or minor signs of atopy were assessed during anamnesis and physical examination. Susceptibility to ultraviolet (UV) B radiation was measured by the onset of a contact hypersensitivity reaction to diphenylcyclopropenone in individuals sensitized in previously irradiated areas. RESULTS: The prevalence of PA was higher in individuals with darker skin, in high phototype categories, as well as in males. The number of daily baths and sun exposure between 10.00 h and 15.00 h were significantly higher in the PA group when compared with controls (P = 0.03 and P = 0.0015, respectively). The presence of atopy signs was more common in pityriasis patients (P = 0.002). Susceptibility to UVB radiation was 29.6% in the PA group vs. 29.0% in the control group; nevertheless, important differences were found after stratification in order to control possible confounding factors. The presence of S. aureus in the nostrils was equal in both groups. CONCLUSIONS: Our results confirm that PA, in our population, is more prevalent in males and in individuals in higher phototype categories. In those with inadequate personal hygiene and sun exposure habits the disease is more accentuated, demonstrating that the xerosis presenting in individuals with atopic diathesis is an important element in the development of the disease. S. aureus is not an important aetiopathogenic factor in PA. Susceptibility to UVB becomes important when related to the patient's phototype. 相似文献
94.
95.
96.
Phylogenetic analysis of human G9P[8] rotavirus strains circulating in Jiangsu,China between 2010 and 2016
下载免费PDF全文
![点击此处可从《Journal of medical virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Cheng Xu MD Jianguang Fu DC Jing Ai MD Jun Zhang MD Cheng Liu BD Xiang Huo MD Changjun Bao MD Yefei Zhu DM 《Journal of medical virology》2018,90(9):1461-1470
Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children’s Hospital between 2010 and 2016 (named JS2010‐JS2016) were analyzed through whole‐genome sequencing. All evaluated strains showed the Wa‐like constellation G9‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1. Furthermore, phylogenetic analysis revealed that the VP7 genes of all strains clustered into lineage G9‐III and G9‐VI. With the exception of strain JS2012 (P[8]‐4), the VP4 sequences of all strains belonged to the P[8]‐3 lineage. Sequencing further revealed that amino acid substitutions were present in the antigenic regions of the VP7 and VP4 genes of all strains. Moreover, there were multiple substitutions in antigenic sites I and II of the nonstructural protein 4 (NSP4) genes, whereas the other NSP genes were relatively conserved. In conclusion, our phylogenetic analysis of these 7 G9P[8] strains suggests that RVA varied across regions and time. Therefore, our findings suggest that continued surveillance is necessary to explore the molecular evolutionary characteristics of RVA for better prevention and treatment of acute viral gastroenteritis. 相似文献
97.
TM Sankary ; G Yang ; JM Romeo ; PP Ulrich ; MP Busch ; BD Rawal ; GN Vyas 《Transfusion》1994,34(8):656-660
BACKGROUND: Since screening for antibody to hepatitis C virus (HCV) was introduced in 1990, posttransfusion hepatitis has been reduced to nearly background levels. This has led to reconsideration of the value of testing donated blood for elevated alanine aminotransferase (ALT). The contribution of ALT testing in detecting seronegative infection was evaluated by the performance of polymerase chain reaction (PCR) for hepatitis B virus (HBV) or HCV in plasma from ALT-elevated blood units. STUDY DESIGN AND METHODS: Testing was performed on 375 units of plasma, derived from an equivalent of 47,500 blood donations, with a highly sensitive hemi-nested PCR procedure. Using a triplet of primers directed at the conserved regions of HBV DNA and 5'-noncoding regions of HCV RNA, the hemi-nested PCR assay can reliably amplify 10 viral molecules to levels detectable in ethidium bromide-stained agarose gels. Pools of plasma from groups of four donors were screened with hemi-nested PCR. For any reactive pools, the plasma from individual donors was retested twice on different aliquots. RESULTS: Two of 375 units, both with midrange ALT elevation, were repeatedly reactive in hemi-nested PCR (one each for HBV DNA and HCV RNA). However, samples from the two suspect donors tested 9 and 5 months later revealed no seroconversion, elevated ALT, or viral genomes in hemi-nested PCR. CONCLUSION: The lack of confirmed HBV or HCV infection in this study representing an estimated 47,500 voluntary blood donations suggests that routine ALT testing for further prevention of posttransfusion hepatitis after exclusion of HBV- and/or HCV-seropositive blood may be superfluous. 相似文献
98.
The effects of dorsal column stimulation on measures of clinical and experimental pain in man 总被引:1,自引:0,他引:1
Despite the extensive use of dorsal column stimulation (DCS) for the control of various chronic pain conditions, most clinicians report only modest success rates. Surprisingly, there has been little placebo-controlled investigation of its efficacy for altering either clinical or experimental pain perception. The current study compared the effects of DCS to placebo stimulation on clinical pain perception, perceived intensity of painful heat stimuli and visual stimuli, and the discrimination of small changes in noxious heat intensity and in light intensity. We found that DCS, but not placebo stimulation, significantly altered ratings of spontaneous clinical pain as well as those of painful cutaneous heat. In addition, heat discrimination thresholds were increased by DCS, but not placebo. On the other hand, DCS had no effect on ratings of visual stimulus intensity nor on visual discrimination, suggesting that the DCS modulation of pain perception was not due to a general change in attention. These data indicate that DCS significantly alters pain transmission in humans. Nevertheless, the relatively small reduction in clinical pain (less than 30%) must be weighed against the invasive nature of electrode implantation. 相似文献
99.
Investigating nasal cytology as a potential tool for diagnosing occupational rhinitis in woodworkers
Claudia Staffieri MD PhD Andrea Lovato MD Federica Aielli MD Martina Bortoletto MD Luciano Giacomelli BD Mariella Carrieri MD Salvatore Romeo MD PhD Paolo Boscolo-Rizzo MD Maria Cristina Da Mosto MD Giovanni Battista Bartolucci MD Gino Marioni MD Maria Luisa Scapellato MD 《International forum of allergy & rhinology》2015,5(9):814-819
100.