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101.
We treated 51 patients with advanced malignant lymphoma refractory to conventional therapy with methyl-glyoxal-bis(guanylhydrazone) (methyl- GAG) at doses ranging from 400 to 800 mg/sq m. Therapy was started on a weekly schedule and was switched to every other week in responding patients at the onset of toxicity. Partial responses were observed in 6 of 13 evaluable patients with Hodgkin's disease (46%), 5 of 10 patients with diffuse poorly differentiated lymphocytic lymphoma (50%), 2 of 4 patients with nodular poorly differentiated lymphocytic lymphoma (50%), and 3 of 13 patients with diffuse histiocytic lymphoma (23%). Two of six patients with mycosis fungoides showed objective improvement in cutaneous disease. Toxicity was generally mild and included muscular weakness, myalgia, mucositis, and diarrhea; two patients developed bronchospasm following drug infusions. We conclude that methyl-GAG has major antitumor activity when administered on this schedule to patients with advanced malignant lymphoma. The low degree of toxicity, unique mechanism of action, and minimal myelosuppressive effects suggest that methyl-GAG will prove useful in future trials of combination chemotherapy regimens for the treatment of lymphoma. 相似文献
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Background
In this study we evaluated the usefulness of a free self-test for screening albuminuria in the general population. 相似文献103.
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Granulocytic sarcoma (chloroma), a rare tumor usually associated with myelogenous leukemia, is capable of invading the meninges or brain parenchyma. Radiologic findings in a case of granulocytic sarcoma of the brain, as well as those in 11 previously reported cases of intracranial leukemic masses, are interpreted. On computed tomographic scans, the lesions can appear isodense or hyperdense, edema and necrosis are variable, and there is uniform enhancement following intravenous administration of contrast material. There may be some affinity for the posterior fossa. 相似文献
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B Hitze A Bosy‐Westphal S Plachta‐Danielzik F Bielfeldt M Hermanussen MJ Müller 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(2):256-262
Aim: This study investigates the effect of rapid weight gain in term children, adolescents and young adults born appropriate for gestational age. Methods: In all, 173 girls and 178 boys aged 6.1–19.9 (12.5 ± 3.1)years participated. Rapid weight gain (group 1) was defined as a change in weight‐SDS (standard deviation score) from birth till two years >0.67, ‘no change’ as ≥?0.67 and ≤0.67 (group 2) vs ‘slow weight gain’ as 0.67 (group 3). BMI‐SDS, waist circumference (WC) z‐score, fat mass (FM)/fat free mass (FFM; Air‐Displacement‐Plethysmography), resting energy expenditure (REE; ventilated hood system), cardio‐metabolic risk factors, serum leptin and adiponectin were assessed. >90th age‐/sex‐specific BMI‐percentile was defined as overweight. Parental BMI, socio‐economic status and lifestyle were assessed as confounders. Results: A total of 22.8% gained weight rapidly, and 15.7% was overweight. Group 1 compared with group 2 and 3 subjects was taller, heavier and had a higher prevalence of overweight (girls/boys: 26.2%/28.9% vs 11.6%/19.0% vs 2.8%/5.0%; p < 0.01/p < 0.05). Concomitantly, a higher WC, %FM and FFM were observed. Rapid weight gain was positively associated with REE (adjusted for FFM) in boys (r = 0.26; p < 0.01), but not with cardio‐metabolic risk factors. Conclusion: Rapid weight gain was related to increases in height, weight, a higher prevalence of overweight and central fat distribution. In addition, rapid weight gain was related to a higher REE in boys, but not to cardio‐metabolic risk factors. 相似文献
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目的 骨唾液酸蛋白(Bone sialoprotein,简称BSP)是由成骨细胞分泌的一种非胶原蛋白质,反映骨转换和骨形成的指标。最近研究认为:血清BSP浓度可反映破骨细胞活性和骨吸收过程,也可能是一个骨吸收指标。本实验测定了血清BSP在人体内的生物变异性。方法 采用RIA 法测定了290例不同性别和年龄的正常人血清BSP的正常值,血清BSP的天-天变异性及24 h 生物周期。 结果 在儿童组血清BSP正常水平明显高于成人组,其最高值在新生儿期和青春期。绝经后妇女其血清浓度比绝经前妇女水平明显升高(P< 0.05)。血清BSP在每天同一时间的波动范围在 7.3% 至17.7% (平均11.7% )。24 h 内有一个明显的生物周期性变化,表现为峰值在凌晨4~8 时,然后逐渐下降直到午后14时为最低。其生物周期的最大波幅为±20% ,(平均血浓度为10.5 ng/m l)。结论 血清BSP反映了骨转换的生理变化与年龄有明显相关性,其血清水平24 h 内有一个明显的生物周期,而天与天之间变异性较小。 相似文献
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