全文获取类型
收费全文 | 2347篇 |
免费 | 281篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 154篇 |
妇产科学 | 44篇 |
基础医学 | 334篇 |
口腔科学 | 94篇 |
临床医学 | 303篇 |
内科学 | 409篇 |
皮肤病学 | 58篇 |
神经病学 | 148篇 |
特种医学 | 195篇 |
外科学 | 293篇 |
综合类 | 74篇 |
一般理论 | 1篇 |
预防医学 | 254篇 |
眼科学 | 69篇 |
药学 | 96篇 |
中国医学 | 4篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 16篇 |
2022年 | 20篇 |
2021年 | 27篇 |
2020年 | 20篇 |
2019年 | 19篇 |
2018年 | 53篇 |
2017年 | 52篇 |
2016年 | 60篇 |
2015年 | 77篇 |
2014年 | 95篇 |
2013年 | 141篇 |
2012年 | 83篇 |
2011年 | 56篇 |
2010年 | 88篇 |
2009年 | 110篇 |
2008年 | 49篇 |
2007年 | 75篇 |
2006年 | 85篇 |
2005年 | 63篇 |
2004年 | 66篇 |
2003年 | 50篇 |
2002年 | 48篇 |
2001年 | 47篇 |
2000年 | 60篇 |
1999年 | 58篇 |
1998年 | 113篇 |
1997年 | 96篇 |
1996年 | 105篇 |
1995年 | 70篇 |
1994年 | 81篇 |
1993年 | 46篇 |
1992年 | 40篇 |
1991年 | 46篇 |
1990年 | 42篇 |
1989年 | 55篇 |
1988年 | 43篇 |
1987年 | 46篇 |
1986年 | 35篇 |
1985年 | 41篇 |
1984年 | 22篇 |
1983年 | 14篇 |
1982年 | 32篇 |
1981年 | 23篇 |
1980年 | 21篇 |
1979年 | 14篇 |
1978年 | 15篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1975年 | 16篇 |
1969年 | 15篇 |
排序方式: 共有2656条查询结果,搜索用时 31 毫秒
31.
D. E. Millhorn T. Hökfelt L. Terenius A. Buchan J. C. Brown 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1987,67(2):420-428
Summary The medulla oblongata and pons of colchicine treated rats were analyzed with a doublestaining technique using mouse monoclonal antibodies to somatostatin and rabbit polyclonal antibodies raised against methionine-enkephalin. Numerous cells reacted with both antisera but cells reacting with only one antiserum were also observed. Double-stained cells were most frequently encountered at all levels of the nucleus tractus solitarii, in a well defined group in the caudal medullary reticular formation, along the lateral ventral surface of the medulla oblongata, dorsolateral to the inferior olive and in the nucleus raphe magnus. These findings provide further examples of coexistence of two peptides and indicate the possibility that somatostatin-and enkephalin-like peptides are co-released. 相似文献
32.
The synthesis of immunoglobulins by the uterine cervix was investigated in an endocervical organ-culture system. Using Ouchterlony immunodiffusion gels immunoglobulin G, immunoglobulin A and secretory piece were detected in washings of endocervical explants and in explant incubation medium. Synthesis of immunoglobulin in the organ-culture system was investigated by polyacrylamide-gel electrophoresis of radiolabelled polypeptides; 2 polypeptides co-migrated with the heavy and light chains of a reference polyclonal immunoglobulin G and were confirmed, by use of anti-human globulin and iodinated staphylococcal protein A, to be the heavy and light chains of immunoglobulin G. This experimental system will provide a useful model in future investigations of the efficacy of a local vaccine in human subjects. 相似文献
33.
34.
As three single-handed practitioners who work in the same health centre, we decided to review our work in clinical management and preventive medicine. We used data contained in a simple medical information system but, where necessary, referred to the original problem-orientated medical records. The results showed that we did not always reach standards which we considered satisfactory but we feel this type of review is worthwhile and could be applied in many general practices. 相似文献
35.
36.
Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy 总被引:3,自引:0,他引:3
Kelsell RE; Gregory-Evans K; Payne AM; Perrault I; Kaplan J; Yang RB; Garbers DL; Bird AC; Moore AT; Hunt DM 《Human molecular genetics》1998,7(7):1179-1184
The dominant cone-rod dystrophy gene CORD6 has previously been mapped to
within an 8 cM interval on chromosome 17p12-p13. The retinal- specific
guanylate cyclase gene (RETGC-1), which maps to within this genetic
interval and previously was implicated in Leber's congenital amaurosis, was
screened for mutations within this family and in a panel of small families
and individuals with various cone and cone- rod dystrophy phenotypes. A
missense mutation (E837D) was identified in affected members of the CORD6
family, as well as a second missense mutation (R838C) in three other
families with dominant cone-rod dystrophy. RETGC-1 is only the fourth gene
to be implicated in cone-rod dystrophy and this is the first report of
dominant mutations in this gene.
相似文献
37.
Localization of a gene for otosclerosis to chromosome 15q25-q26 总被引:5,自引:0,他引:5
Tomek MS; Brown MR; Mani SR; Ramesh A; Srisailapathy CR; Coucke P; Zbar RI; Bell AM; McGuirt WT; Fukushima K; Willems PJ; Van Camp G; Smith RJ 《Human molecular genetics》1998,7(2):285-290
Among white adults otosclerosis is the single most common cause of hearing
impairment. Although the genetics of this disease are controversial, the
majority of studies indicate autosomal dominant inheritance with reduced
penetrance. We studied a large multi- generational family in which
otosclerosis has been inherited in an autosomal dominant pattern. Five of16
affected persons have surgically confirmed otosclerosis; the remaining nine
have a conductive hearing loss but have not undergone corrective surgery.
To locate the disease- causing gene we completed genetic linkage analysis
using short tandem repeat polymorphisms (STRPs) distributed over the entire
genome. Multipoint linkage analysis showed that only one genomic region, on
chromosome 15q, generated a lod score >2.0. Additional STRPs were typed
in this area, resulting in a lod score of 3.4. STRPs FES (centromeric) and
D15S657 (telomeric) flank the 14. 5 cM region that contains an otosclerosis
gene.
相似文献
38.
39.
Contraceptive potential of a mifepristone-nomegestrol acetate sequential regimen in women 总被引:1,自引:0,他引:1
Croxatto HB; Salvatierra AM; Fuentealba B; Massai R 《Human reproduction (Oxford, England)》1998,13(12):3297-3302
The effectiveness of a sequential regimen consisting of mifepristone, 10
mg/day for 15 days, followed by nomegestrol acetate (NOMA), 5 mg/day for
the next 13 days, for inhibiting ovulation and maintaining regular bleeding
cycles was assessed in 10 surgically sterilized volunteers who were
followed for one pretreatment and three treated cycles. Hormonal
determinations in blood and urine, ovarian ultrasonography, bleeding
records in all cycles and an endometrial biopsy taken on day 22-25 of the
third treatment cycle were used to monitor the effects of treatment. During
treatment, 24 monophasic (no sustained progesterone rise above 12 nmol/l)
and six biphasic cycles were recorded. Nine follicular ruptures were
detected echographically in these 30 treated cycles, five of which occurred
in monophasic cycles. All follicular ruptures occurred on days 1-7 of NOMA
treatment. Echographic and endocrine features of ovulatory cycles were both
present in only four treated cycles (13.3%). Development of a secretory
endometrium was achieved in all cases, but it was always irregular. Regular
withdrawal bleeding occurred in all subjects and no adverse reactions were
recorded. The ovarian and endometrial effects of this regimen justify
testing its contraceptive effectiveness in phase 2 clinical trials.
相似文献
40.
A Srour AM El Tantawi N Khouja A Zouaoui J-P Lassau J Philippon Ph Cornu 《Surgical and radiologic anatomy : SRA》1994,16(1):117-119
Summary The anterior interhemispheric approach for aneurysms of the anterior communicating artery was studied in ten cadavers. This approach presents several advantages over the pterional approach widely used in neurosurgery. It allows direct access to the region of the anterior communicating artery complex with minimal retraction of the brain and preservatioin of the olfactory tract and the gyrus rectus.
Bases anatomiques de l'abord inter-hémisphérique antérieur lors de la chirurgie des anévrysmes de l'artère communicante antérieure
Résumé Ce travail concerne l'abord neurochirurgical des anévrysmes de l'artére communicante antérieure par voie frontale interhémisphérique. L'étude anatomique a été réalisée sur dix sujets. Cette exposition possède de nombreux avantages comparée à la voie ptérionale habituelle : voie d'abord reduite médiane permettant une visualisation directe et symétrique du complexe artériel de l'artére communicante antérieure ; avec le moindre manipulation et retraction du cerveau en respectant les voies olfactives et le gyrus rectus.相似文献