全文获取类型
收费全文 | 332篇 |
免费 | 13篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 13篇 |
妇产科学 | 2篇 |
基础医学 | 31篇 |
口腔科学 | 7篇 |
临床医学 | 39篇 |
内科学 | 46篇 |
皮肤病学 | 11篇 |
神经病学 | 6篇 |
特种医学 | 77篇 |
外科学 | 42篇 |
综合类 | 30篇 |
预防医学 | 12篇 |
眼科学 | 3篇 |
药学 | 5篇 |
中国医学 | 6篇 |
肿瘤学 | 15篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 12篇 |
2020年 | 7篇 |
2019年 | 2篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 12篇 |
2013年 | 13篇 |
2012年 | 16篇 |
2011年 | 11篇 |
2010年 | 14篇 |
2009年 | 13篇 |
2008年 | 9篇 |
2007年 | 15篇 |
2006年 | 13篇 |
2005年 | 16篇 |
2004年 | 19篇 |
2003年 | 18篇 |
2002年 | 8篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 6篇 |
1998年 | 7篇 |
1997年 | 10篇 |
1996年 | 13篇 |
1995年 | 7篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 6篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1959年 | 1篇 |
1954年 | 1篇 |
1936年 | 1篇 |
排序方式: 共有351条查询结果,搜索用时 15 毫秒
81.
P. A. NAESS G. CHRISTENSEN K. A. KIRKEB
EN F. KIIL 《Acta physiologica (Oxford, England)》1992,145(4):369-375
Experiments were undertaken in two groups of barbiturate anaesthetized dogs to examine whether atrial natriuretic factor (ANF) exerts an effect on renal release of prostaglandin E2 (PGE2). In the first group, intravenous infusion of ANF (50 ng min-1kg-1body wt) reduced basal PGE2 release from 4.4 ± 0.8 pmol min-1to 1.8 ± 0.7 pmol min-1. In the second group, intrarenal infusion of an α-adrenoceptor agonist, phenylephrine (2.5–6.75 μg min-1), raised PGE2 release from 2.7 ± 0.5 pmol min-1to 7.5 ± 1.3 pmol min-1. During continuous α1-adrenergic stimulation, intravenous infusion of ANF (100 ng min-1kg-1body wt) reduced PGE2 release to 3.5 ± 1.0 pmol min-1. These results demonstrate that ANF reduces basal and α1-adrenergic stimulated renal PGE2 release. 相似文献
82.
Heringer-Walther S Batista EN Walther T Khosla MC Santos RA Campagnole-Santos MJ 《Hypertension》2001,37(5):1309-1314
ACE inhibitors are extensively used in the treatment of hypertension mainly because of their efficiency in reducing blood pressure levels and decreasing vascular and cardiac hypertrophy. In addition, ACE inhibitors improve baroreceptor reflex control. Chronic inhibition of ACE produces (in addition to decreased angiotensin II levels) a severe increase in angiotensin-(1-7) [Ang-(1-7)] levels in several species. We have previously shown that Ang-(1-7) produces a facilitation of the baroreflex control of heart rate. In this study, we evaluated the participation of endogenous Ang-(1-7) in the improvement of baroreflex sensitivity in spontaneously hypertensive rats after central infusion of ramiprilat, an ACE inhibitor. Reflex changes in heart rate were elicited, in conscious rats, by bolus injections of phenylephrine (baroreflex bradycardia) before and after intracerebroventricular infusion of (1) saline (8 microL/h), 4 hours (n=5); (2) ramiprilat (14 microg/h), 4 hours (n=6); (3) ramiprilat for 2 hours, followed by ramiprilat combined with A-779 (4 microg/h), a selective Ang-(1-7) antagonist, for an additional 2 hours (n=6); and (4) A-779 for 2 hours, followed by A-779 combined with ramiprilat for an additional 2 hours (n=5). Intracerebroventricular infusion of ramiprilat produced an important increase ( approximately 40%) in baroreflex sensitivity (evaluated as the ratio between changes in heart rate and changes in mean arterial pressure) that was completely reversed by A-779. Furthermore, intracerebroventricular infusion of A-779 prevented the improvement of the baroreflex sensitivity produced by ramiprilat. Intracerebroventricular infusion of saline or A-779 alone did not significantly alter the baroreflex sensitivity. These results suggest that endogenous Ang-(1-7) is involved in the improvement of baroreflex sensitivity observed in spontaneously hypertensive rats during central ACE inhibition. 相似文献
83.
目的:探讨RSS椎弓根钉内固定结合植骨融合治疗腰椎间盘突出症伴腰椎不稳的临床效果。方法将本院2011年9月~2013年9月收治的44例腰椎间盘突出症伴腰椎不稳患者按不同手术治疗方案随机分为对照组21例和观察组23例,对照组采用髓核摘除+经后路关节突单纯植骨融合手术治疗,观察组采用RSS椎弓根钉内固定+植骨融合手术治疗,比较两组的围术期情况、JOA评分、植骨融合情况。结果两组的手术耗时、术中出血量及住院时间比较差异无统计学意义(P〉0.05)。两组术后6个月的JOA评分均明显高于术前(P〈0.05);观察组术后6个月的JOA评分高于对照组(P〈0.05)。两组植骨融合成功率比较差异有统计学意义(P〈0.05)。结论RSS椎弓根钉内固定结合植骨融合治疗腰椎间盘突出症伴腰椎不稳具有植骨融合率高、远期恢复效果显著等优点,值得临床推广应用。 相似文献
84.
85.
86.
87.
Effect of phagocytosis on the reduced soluble sulfhydryl content of human granulocytes 总被引:3,自引:0,他引:3
The role of reduced glutathione in relation to hexose monophosphate shunt activity and peroxide detoxification has been well established in human erythrocytes. Less is known about the content of reduced glutathione in phagocytic leukocytes and the changes that occur during functional activity. We have measured the reduced sulfhydryl content of normal resting human granulocytes and of cells isolated from a patient with chronic granulomatous disease. Normal cells and those from the patient with chronic granulomatous disease contained similar concentrations of reduced sulfhydryls. Stimulation of a phagocytic response by incubation with opsonized zymosan particles resulted in prompt and nearly complete depletion of intracellular glutathione from normal granulocytes. This fall in reduced glutathione concentration was dependent on the phagocytic load. Exposure of chronic granulomatous disease granulocytes to a similar phagocytic load resulted in a slower and less complete fall in reduced glutathione. In normal cells, those from the chronic granulomatous disease patient, and those from an obligate carrier of the disease, the decrement in reduced glutathione during phagocytosis was correlated with oxidation of 14C-1-glucose and 14C-formate, nitroblue tetrazolium reduction, and the chemiluminescence phenomenon. 相似文献
88.
Thanos L Zormpala A Papaioannou G Malagari K Brountzos E Kelekis D 《European Journal of Internal Medicine》2005,16(8):571-574
BACKGROUND: Computed tomography (CT)-guided liver biopsy using large-caliber cutting needles allows the recovery of larger tissue specimens that are more suitable for establishing histological diagnosis. Yet, large-caliber needles are associated with higher rates of post-biopsy bleeding. The aim of this prospective study was to assess the efficacy and safety of the method, when all of the procedures were performed by experienced radiologists and all patients were carefully evaluated and treated, when needed, before the biopsy. METHODS: A total of 767 consecutive patients with focal hepatic lesions underwent CT-guided liver biopsy during a 5-year period. The procedures were performed in a single center using 18-gauge automated biopsy guns with a 2-cm cutting edge by a team of experienced radiologists (>100 procedures performed by each one before the initiation of the study). Before the procedure, abnormal coagulation indices were corrected, ascites was treated and, in all cases, an adequate parenchymal cuff of normal tissue between the lesion and the capsule was retained. RESULTS: In all cases the extracted specimens were adequate for diagnosis. No major complications (i.e., death or complications requiring surgery, chest tube, or blood transfusions) were observed. Minor complications (i.e., those not requiring medical intervention) were observed in three patients. CONCLUSIONS: Percutaneous CT-guided liver biopsy using an 18-gauge automated needle is a safe and effective procedure. Careful pre-biopsy evaluation and treatment, when needed, and maintenance of an adequate parenchymal cuff between the lesion and the capsule contribute to the safety of the method. 相似文献
89.
目的探讨冠心病合并糖尿病患者经皮冠状动脉介入(PCI)置入EXCEL可降解涂层雷帕霉素洗脱支架(SES)治疗的远期疗效。方法回顾性随机入选2007年1月至2007年12月住院期间冠心病合并糖尿病患者行PCI162例,并入选同时期150例无糖尿病的冠心病患者行PCI为对照组。随访5年,随访包括心绞痛复发、死亡、心肌梗死、卒中和再次血运重建的主要不良心脑血管事件。结果两组支架术成功率均为100%。随访率100%,随访5年,糖尿病组与非糖尿病组术后并发症发生率(8.8%、7.0%)、卒中发生率(3.9%、3.0%)、心源性死亡率(0.0%、0.0%)差异无统计学意义(均为P〉0.05)。再次血运重建率(30.4%、14.0%)、心绞痛复发率(42,1%、30.0%)、全因死亡率(9.8%、2.0%)糖尿病组高于非糖尿病组;但心源性病死率均为0.0%。结论选择性冠脉内置入药物洗脱支架安全,成功率高,远期疗效尚好,但糖尿病仍是远期不良预后的独立预测因素。 相似文献
90.