Lymphocyte blastogenesis in patients receiving hemodialysis.

Lymphocyte blastogenic transformation in response to plant lectins and allogenic cells was studied in patients with nonuremic, far-advanced, chronic renal failure and in healthy controls. Cell cultures were studied in the presence of normal sera, patient's sera, and with media of different buffering capacities. Minimal blastogenic depression was observed when patient's lymphocytes were cultured in indifferent plasma with effective bicarbonate buffering compared with the use of pooled patient's plasma or HEPES buffer. Fresh plasma in culture depressed concanavalin A (Con A) blastogenesis. The data suggest that, under optimal conditions, lymphocytes from patients with chronic severe renal insufficiency are more responsive to stimuli than previously reported and as a group are near normal control values. Further, the defect observed may be a result of intracellular acidosis.     

The effect of deprivation and HbA1c on admission to hospital for diabetic ketoacidosis in type 1 diabetes

Aims/hypothesis  

Diabetic ketoacidosis is a potentially life-threatening complication of diabetes and has a strong relationship with HbA_1c. We examined how socioeconomic group affects the likelihood of admission to hospital for diabetic ketoacidosis.     

Avoiding and managing the failure of conventional crowns and bridges

The replacement of crowns and bridges is a common procedure for many dental practitioners. When correctly planned and executed, fixed prostheses will provide predictable function, aesthetics and value for money. However, when done poorly, they are more likely to fail prematurely and lead to irreversible damage to the teeth and supporting structures beneath. Sound diagnosis, assessment and technical skills are essential when dealing with failed or failing fixed restorations. These skills are essential for the 21st century dentist. This paper, with treated clinical examples, illustrates the areas of technical skill and clinical decisions needed for this type of work. It also provides advice on how the risk of premature failure can, in general, be further reduced. The article also confirms the very real risk in the UK of dento-legal problems when patients experience unexpected problems with their crowns and bridges. Clinical Relevance: This paper outlines clinical implications of failed fixed prosthodontics to the dental surgeon. It also discusses factors that we can all use to predict and reduce the risk of premature restoration failure. Restoration design, clinical execution and patient factors are the most frequent reasons for premature problems. It is worth remembering (and informing patients) that the health of the underlying supporting dental tissue is often irreversibly compromised at the time of fixed restoration failure.