全文获取类型
收费全文 | 2406篇 |
免费 | 239篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 68篇 |
妇产科学 | 20篇 |
基础医学 | 306篇 |
口腔科学 | 30篇 |
临床医学 | 305篇 |
内科学 | 513篇 |
皮肤病学 | 27篇 |
神经病学 | 217篇 |
特种医学 | 138篇 |
外科学 | 255篇 |
综合类 | 39篇 |
预防医学 | 290篇 |
眼科学 | 23篇 |
药学 | 162篇 |
中国医学 | 8篇 |
肿瘤学 | 216篇 |
出版年
2022年 | 18篇 |
2021年 | 27篇 |
2020年 | 38篇 |
2019年 | 46篇 |
2018年 | 54篇 |
2017年 | 44篇 |
2016年 | 45篇 |
2015年 | 49篇 |
2014年 | 52篇 |
2013年 | 75篇 |
2012年 | 87篇 |
2011年 | 111篇 |
2010年 | 62篇 |
2009年 | 64篇 |
2008年 | 77篇 |
2007年 | 93篇 |
2006年 | 100篇 |
2005年 | 79篇 |
2004年 | 87篇 |
2003年 | 79篇 |
2002年 | 77篇 |
2001年 | 68篇 |
2000年 | 83篇 |
1999年 | 60篇 |
1998年 | 30篇 |
1997年 | 33篇 |
1996年 | 33篇 |
1995年 | 24篇 |
1994年 | 45篇 |
1993年 | 32篇 |
1992年 | 43篇 |
1991年 | 62篇 |
1990年 | 47篇 |
1989年 | 69篇 |
1988年 | 51篇 |
1987年 | 58篇 |
1986年 | 44篇 |
1985年 | 38篇 |
1984年 | 37篇 |
1983年 | 38篇 |
1982年 | 17篇 |
1981年 | 20篇 |
1979年 | 39篇 |
1978年 | 39篇 |
1977年 | 30篇 |
1976年 | 29篇 |
1975年 | 20篇 |
1973年 | 21篇 |
1972年 | 20篇 |
1969年 | 20篇 |
排序方式: 共有2652条查询结果,搜索用时 15 毫秒
51.
52.
BKV‐specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA‐haploidentical haematopoietic cell transplantation 下载免费PDF全文
53.
Lefevre M Lovejoy JC Smith SR Delany JP Champagne C Most MM Denkins Y de Jonge L Rood J Bray GA 《Metabolism: clinical and experimental》2005,54(12):553-1658
Trans-fatty acids have been implicated as a risk factor for cardiovascular disease and diabetes. In addition, a polymorphism at codon 54 (Ala54Thr) in the fatty acid-binding protein 2 (FABP2) gene has been suggested to modify an interaction between dietary fat and insulin sensitivity. We examined the postprandial metabolic profiles after meals enriched with C18:1trans- relative to a similar meal with C18:1cis-fatty acid in individuals who were either FABP2 Ala54 homozygotes or Thr54 carriers. Moderately overweight men and women ate 2 breakfast test meals, separated by 1 week, each providing 40% of their daily energy requirement and containing 50% of energy as fat. In one meal, 10% of energy was from C18:1trans, and in the other meal, the C18:1trans was replaced with C18:1cis. Metabolic parameters were assessed during an 8-hour period. Insulin and C-peptide levels increased more after the C18:1trans meal, and this was associated with a greater fall in free fatty acids. Postprandial glucose levels and oxidation of fatty acids and carbohydrate were not different between the 2 test meals. The Thr54 allele for FABP2 increased the rise in postprandial glucose but not triacylglycerols. Fractional triacylglycerol synthetic rates were higher after consumption of the C18:1trans meal relative to the C18:1cis meal only in Thr54 carriers. These data show that a single meal enriched with C18:1trans-fatty acids can significantly increase insulin resistance, and that in the presence of the FABP2 Thr54 allele, may contribute to increased partitioning of glucose to triacylglycerols and insulin resistance. 相似文献
54.
55.
Bray Emily E. Zheng Zihan Tolbert M. Katherine McCoy Brianah M. Kaeberlein Matt Kerr Kathleen F. 《Age (Dordrecht, Netherlands)》2022,44(3):1779-1790
GeroScience - A variety of diets have been studied for possible anti-aging effects. In particular, studies of intermittent fasting and time-restricted feeding in laboratory rodents have found... 相似文献
56.
Jones K Bray PG Khoo SH Davey RA Meaden ER Ward SA Back DJ 《AIDS (London, England)》2001,15(11):1353-1358
BACKGROUND: The multidrug transporters P-glycoprotein (P-gp) and MRP1 are functionally expressed in several subclasses of lymphocytes. HIV-1 protease inhibitors interact with both; consequently the transporters could reduce the local concentration of HIV-1 protease inhibitors and, thus, influence the selection of viral mutants. OBJECTIVES: To study the effect of the expression of P-gp and MRP1 on the transport and accumulation of HIV-1 protease inhibitors in human lymphocytes and to study the effects of specific P-gp and MRP1 inhibitors. METHODS: The initial rate and the steady-state intracellular accumulation of radiolabelled ritonavir, indinavir, saquinavir and nelfinavir was measured in three human lymphocyte cell lines: control CEM cells, CEM-MDR cells, which express 30-fold more P-gp than CEM cells, and CEM-MRP cells, which express fivefold more MRP1 protein than CEM cells. The effect of specific inhibitors of P-gp (GF 120918) and MRP1 (MK 571) was also examined. RESULTS: Compared with CEM cells, the initial rates of uptake and the steady-state intracellular concentrations of all protease inhibitors are significantly reduced in CEM-MDR cells. The intracellular concentrations of the protease inhibitors are increased upon co-administration with GF 120918, in some cases to levels approaching those in CEM cells. The intracellular concentrations of the protease inhibitors are also significantly reduced in CEM-MRP cells. Co-administration with MK -571 can partially overcome these effects. CONCLUSIONS: The overexpression of multidrug transporters significantly reduces the accumulation of protease inhibitors at this major site of virus replication, which, potentially, could accelerate the acquisition of viral resistance. Targeted inhibition of P-gp may represent an important strategy by which this problem can be overcome. 相似文献
57.
58.
JPMHN report on the 2018 Skellern Lecture and JPHMN Lifetime Achievement Award—held at the University of Greenwich Maritime Campus,June 14th 2018 下载免费PDF全文
59.
Kensaku Kawamoto Cary J Martin Kip Williams Ming-Chieh Tu Charlton G Park Cheri Hunter Catherine J Staes Bruce E Bray Vikrant G Deshmukh Reid A Holbrook Scott J Morris Matthew B Fedderson Amy Sletta James Turnbull Sean J Mulvihill Gordon L Crabtree David E Entwistle Quinn L McKenna Michael B Strong Robert C Pendleton Vivian S Lee 《J Am Med Inform Assoc》2015,22(1):223-235
Objective To develop expeditiously a pragmatic, modular, and extensible software framework for understanding and improving healthcare value (costs relative to outcomes).Materials and methods In 2012, a multidisciplinary team was assembled by the leadership of the University of Utah Health Sciences Center and charged with rapidly developing a pragmatic and actionable analytics framework for understanding and enhancing healthcare value. Based on an analysis of relevant prior work, a value analytics framework known as Value Driven Outcomes (VDO) was developed using an agile methodology. Evaluation consisted of measurement against project objectives, including implementation timeliness, system performance, completeness, accuracy, extensibility, adoption, satisfaction, and the ability to support value improvement.Results A modular, extensible framework was developed to allocate clinical care costs to individual patient encounters. For example, labor costs in a hospital unit are allocated to patients based on the hours they spent in the unit; actual medication acquisition costs are allocated to patients based on utilization; and radiology costs are allocated based on the minutes required for study performance. Relevant process and outcome measures are also available. A visualization layer facilitates the identification of value improvement opportunities, such as high-volume, high-cost case types with high variability in costs across providers. Initial implementation was completed within 6 months, and all project objectives were fulfilled. The framework has been improved iteratively and is now a foundational tool for delivering high-value care.Conclusions The framework described can be expeditiously implemented to provide a pragmatic, modular, and extensible approach to understanding and improving healthcare value. 相似文献
60.
Understanding patients and spouses experiences of patient education following a cardiac event and eliciting attitudes and preferences towards incorporating cardiopulmonary resuscitation training: A qualitative study 下载免费PDF全文
Susie Cartledge Susan Feldman Janet E. Bray Dion Stub Judith Finn 《Journal of advanced nursing》2018,74(5):1157-1169