首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1335483篇
  免费   114680篇
  国内免费   6363篇
耳鼻咽喉   16700篇
儿科学   42989篇
妇产科学   36545篇
基础医学   183567篇
口腔科学   36271篇
临床医学   120568篇
内科学   278248篇
皮肤病学   31884篇
神经病学   110447篇
特种医学   55526篇
外国民族医学   274篇
外科学   210297篇
综合类   31520篇
现状与发展   2篇
一般理论   414篇
预防医学   106514篇
眼科学   28067篇
药学   93685篇
  5篇
中国医学   2227篇
肿瘤学   70776篇
  2018年   13373篇
  2017年   10629篇
  2016年   12793篇
  2015年   14296篇
  2014年   19944篇
  2013年   29731篇
  2012年   36232篇
  2011年   38880篇
  2010年   24368篇
  2009年   23900篇
  2008年   36358篇
  2007年   38773篇
  2006年   39895篇
  2005年   38485篇
  2004年   36724篇
  2003年   35819篇
  2002年   33830篇
  2001年   66052篇
  2000年   67917篇
  1999年   56587篇
  1998年   16723篇
  1997年   15018篇
  1996年   16014篇
  1995年   16232篇
  1994年   15098篇
  1993年   14153篇
  1992年   47098篇
  1991年   45747篇
  1990年   43970篇
  1989年   41815篇
  1988年   38758篇
  1987年   38081篇
  1986年   35859篇
  1985年   34635篇
  1984年   26358篇
  1983年   22108篇
  1982年   13847篇
  1981年   12447篇
  1980年   11718篇
  1979年   23544篇
  1978年   17072篇
  1977年   14385篇
  1976年   13182篇
  1975年   13722篇
  1974年   16093篇
  1973年   15396篇
  1972年   14173篇
  1971年   13036篇
  1970年   11880篇
  1969年   11101篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
161.
162.

Objectives

This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital.

Methods

A total of 141 S. pneumoniae strains isolated between 2009–2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility testing was performed the disk diffusion method. MICs of penicillin G, amoxicillin and cefotaxime were determined by Etest. Serotyping was inferred from the results of multiplex PCR targeting 40 serotypes. Sequence types (STs) were determined by multilocus sequence typing (MLST).

Results

Among the 141 S. pneumoniae isolates, 98 (69.5%) were resistant to erythromycin. Evaluation of β-lactam susceptibility showed that 90 strains (63.8%) were non-susceptible to penicillin, whereas 48 (34.0%) had decreased susceptibility to amoxicillin and 21 (14.9%) to cefotaxime. Twenty-five serotypes were detected, and 10 isolates were classified as non-typeable. Vaccine coverage was 56.7%, 60.3% and 75.2% for pneumococcal conjugate vaccine 7 (PCV7), PCV10 and PCV13, respectively. Overall, 73 STs were identified, including 23 described for the first time. The most frequent STs were ST179 (n?=?17), ST3772 (n?=?14), ST2918 (n?=?10) and ST4003 (n?=?5), related to serotypes 19F, 19A, 14 and 23F, respectively. Moreover, 110 strains were classified within 45 STs. Three international antimicrobial-resistant clones were found, including Denmark14-ST230 (n?=?22), Spain9V-ST156 (n?=?22) and Portugal19F-ST177 (n?=?20).

Conclusion

This study emphasises the clonal and international dissemination of antimicrobial-resistant S. pneumoniae clones. Significant differences in genetic variation were documented by MLST within the various serotypes identified.  相似文献   
163.
164.
165.
166.
We report a case of dichorionic, diamniotic twins who developed similar erythematous, annular, erosive plaques in the inguinal folds in the first few weeks of life that were refractory to topical antifungals and oral antibiotics. The twins were found to have high transaminase levels, antinuclear antibody positivity, and anti‐SSS/Ro) and anti‐SSB/La autoantibodies. The rash resolved without scarring by 7 months of age with the use of low‐potency topical corticosteroids. We suggest that physicians consider neonatal lupus erythematosus in neonates with atypical eruptions occurring in sun‐protected skin.  相似文献   
167.
Pediatric dermatology is one of the smallest subspecialties, and expanding the availability of care is of great interest. Teledermatology has been proposed as a way to expand access and improve care delivery, but no current assessment of pediatric teledermatology exists. The objective of the current study was to assess usage and perspectives on pediatric teledermatology. Surveys were distributed electronically to all 226 board‐certified U.S. pediatric dermatologists; 44% (100/226) responded. Nearly all respondents (89%) have experience with teledermatology. Formal teledermatology reimbursement success rates have increased to 35%. Respondents were positive about teledermatology's present and future prospects, and 41% want to use teledermatology more often, although they viewed teledermatology as somewhat inferior to in‐person care regarding accuracy of diagnosis and appropriation of management plans. Significant differences were found between formal teledermatology users and nonusers in salary structure, practice environment, sex, and region. Substantial increases in pediatric teledermatology have occurred in the last 5 to 10 years, and there remains cause for optimism for teledermatology's future. Concerns about diagnostic confidence and care quality indicate that teledermatology may be best for care of patients with characteristic clinical presentations or management of patients with established diagnoses.  相似文献   
168.
We present the case of 7‐year‐old African American girl with loose anagen syndrome. Although this is a common cause of hair loss in Caucasian children, and there have been reports of cases occurring in dark‐skinned children of North African and Middle Eastern descent, to our knowledge there have been no cases reported in black children of sub‐Saharan African ancestry. We present this case to broaden the differential diagnosis of hair loss in African Americans.  相似文献   
169.
170.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号