全文获取类型
收费全文 | 5097篇 |
免费 | 279篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 361篇 |
妇产科学 | 79篇 |
基础医学 | 437篇 |
口腔科学 | 181篇 |
临床医学 | 323篇 |
内科学 | 1130篇 |
皮肤病学 | 269篇 |
神经病学 | 294篇 |
特种医学 | 123篇 |
外科学 | 741篇 |
综合类 | 186篇 |
预防医学 | 244篇 |
眼科学 | 304篇 |
药学 | 431篇 |
中国医学 | 13篇 |
肿瘤学 | 239篇 |
出版年
2023年 | 32篇 |
2022年 | 69篇 |
2021年 | 170篇 |
2020年 | 75篇 |
2019年 | 152篇 |
2018年 | 188篇 |
2017年 | 130篇 |
2016年 | 157篇 |
2015年 | 165篇 |
2014年 | 211篇 |
2013年 | 225篇 |
2012年 | 384篇 |
2011年 | 447篇 |
2010年 | 233篇 |
2009年 | 177篇 |
2008年 | 246篇 |
2007年 | 284篇 |
2006年 | 207篇 |
2005年 | 196篇 |
2004年 | 170篇 |
2003年 | 142篇 |
2002年 | 159篇 |
2001年 | 109篇 |
2000年 | 114篇 |
1999年 | 90篇 |
1998年 | 41篇 |
1997年 | 19篇 |
1996年 | 20篇 |
1995年 | 35篇 |
1994年 | 17篇 |
1992年 | 69篇 |
1991年 | 64篇 |
1990年 | 41篇 |
1989年 | 37篇 |
1988年 | 53篇 |
1987年 | 39篇 |
1986年 | 32篇 |
1985年 | 38篇 |
1984年 | 27篇 |
1983年 | 23篇 |
1979年 | 22篇 |
1977年 | 15篇 |
1975年 | 16篇 |
1974年 | 26篇 |
1973年 | 15篇 |
1972年 | 27篇 |
1971年 | 19篇 |
1970年 | 15篇 |
1969年 | 16篇 |
1968年 | 18篇 |
排序方式: 共有5386条查询结果,搜索用时 62 毫秒
101.
Nilay Kumar Ambarish Pandey Neetika Garg Emmanuel Sampene Carl J. Lavie 《Mayo Clinic proceedings. Mayo Clinic》2018,93(9):1185-1190
Objective
To ascertain whether temporal and geographic interest in seeking cardiovascular disease (CVD) information online follows seasonal and geographic patterns similar to those observed in real-world data.Methods
We searched Google Trends for popular search terms relating to CVD. Relative search volumes (RSVs) were obtained for the period January 4, 2004, to April 19, 2014, for the United States and Australia. We compared average RSVs by month and season and used cosinor analysis to test for seasonal variation in RSVs. We also assessed correlations between state-level RSVs and CVD burden using an ecological correlational design.Results
RSVs were 15% higher in the United States and 45% higher in Australia for winter compared with summer (P<.001 for difference for both). In the United States, RSVs were 36% higher in February compared with August, while in Australia, RSVs were 75% higher in August compared with January. On cosinor analysis, we found a significant seasonal variability in RSVs, with winter peaks and summer troughs for both the United States and Australia (P<.001 for zero amplitude test for both). We found a significant correlation between state-level RSVs and mortality from CVD (r=0.62; P<.001), heart disease (r=0.58; P<.001), coronary heart disease (r=0.48; P<.001), heart failure (r=0.51; P<.001), and stroke (r=0.60; P<.001).Conclusion
Google search query volumes related to CVD follow strong seasonal patterns with winter peaks and summer troughs. There is moderate to strong positive correlation between state-level search query volumes and burden of CVD mortality. 相似文献102.
103.
Chao Gao Piotr Buszman Paweł Buszman Ply Chichareon Rodrigo Modolo Scot Garg Kuniaki Takahashi Hideyuki Kawashima Rutao Wang Chun Chin Chang Norihiro Kogame Mariusz Tomaniak Masafumi Ono Hironori Hara Ton Slagboom Adel Aminian Christoph Kurt Naber Didier Carrie Aleksander Zurakowski 《The Canadian journal of cardiology》2021,37(1):122-130
BackgroundRadial artery access has been shown to reduce mortality and bleeding events, especially in patients with acute coronary syndromes. Despite this, interventional cardiologists experienced in femoral artery access still prefer that route for percutaneous coronary intervention. Little is known regarding the merits of each vascular access in patients stratified by their risk of bleeding.MethodsPatients from the Global Leaders trial were dichotomized into low or high risk of bleeding by the median of the PRECISE-DAPT score. Clinical outcomes were compared at 30 days.ResultsIn the overall population, there were no statistical differences between radial and femoral access in the rate of the primary end point, a composite of all-cause mortality, or new Q-wave myocardial infarction (MI) (hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.42-1.15). Radial access was associated with a significantly lower rate of the secondary safety end point, Bleeding Academic Research Consortium (BARC) 3 or 5 bleeding (HR 0.55, 95% CI 0.36-0.84). Compared by bleeding risk strata, in the high bleeding score population, the primary (HR 0.47, 95% CI 0.26-0.85; P = 0.012; Pinteraction = 0.019) and secondary safety (HR 0.57, 95% CI 0.35-0.95; P = 0.030; Pinteraction = 0.631) end points favoured radial access. In the low bleeding score population, however, the differences in the primary and secondary safety end points between radial and femoral artery access were no longer statistically significant.ConclusionsOur findings suggest that the outcomes of mortality or new Q-wave MI and BARC 3 or 5 bleeding favour radial access in patients with a high, but not those with a low, risk of bleeding. Because this was not a primary analysis, it should be considered hypothesis generating. 相似文献
104.
Akanksha Garg Akshay Shivchhand Sandip Shah Kamlesh Shah Kinnari Patel Harsha Panchal Apurva Patel Sonia Parikh 《Indian journal of hematology & blood transfusion》2021,37(3):458
Early mixed chimerism (MC) can lead to secondary graft rejection post allogeneic hematopoietic stem cell transplantation in transfusion dependent thalassemia (TDT) patients. Reduction of immunosuppression and donor lymphocyte infusions is the mainstay for treating MC. We report our experience of administering unmanipulated stem cell boost (SCB) in reversing progressive early MC. There were 70 transplants done for 69 TDT patients at our center between September 2005 and January 2020. Mixed chimerism was defined by > 5% recipient cells and the severity was assigned according to the proportion of recipient cells as level 1 = < 10%, level 2 = 10–25%, level 3 = > 25%. For patients developing MC level 2 and 3, we administered unmanipulated SCB and analyzed its safety and efficacy. Out of 70 transplants 7 (10%) had MC level 2 (3/7) and 3 (4/7). These patients received unmanipulated SCB at a median CD34 cell dose of 4.5 × 106/kg (range—3.5 × 106/kg–5.5 × 106/kg). Overall Response (stable MC and/or transfusion independency) to unmanipulated SCB was seen in 5 patients (71.4%). Five patients (71.4%) developed acute graft versus host disease (GVHD) of which 1 patient expired due to severe GVHD. SCB infusion was well tolerated by majority of our patients. The 3 year overall survival and thalassemia free survival was 85.7% (6/7) and 57.1% (4/7) respectively. Timely monitoring of chimerism is important for detecting early MC. Development of acute GVHD is common after administration of unmanipulated SCB and requires vigilance and prompt management. Unmanipulated SCB is a feasible modality for treating progressive MC and salvaging the graft especially in resource-constrained settings. 相似文献
105.
106.
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma 总被引:1,自引:0,他引:1
Shi J Tricot GJ Garg TK Malaviarachchi PA Szmania SM Kellum RE Storrie B Mulder A Shaughnessy JD Barlogie B van Rhee F 《Blood》2008,111(3):1309-1317
Human leukocyte antigen class I molecules expressed by tumor cells play a central role in the regulation of natural killer (NK) cell-mediated immune responses. The proteasome inhibitor bortezomib has demonstrated significant activity in multiple myeloma (MM). We hypothesized that treatment of MM with bortezomib results in the reduction of cell-surface expression of class I and thereby sensitizes MM to NK cell-mediated lysis. Here we report that bortezomib down-regulates class I in a time- and dose-dependent fashion on all MM cell lines and patient MM cells tested. Downregulation of class I can also be induced in vivo after a single dose of 1.0 mg/m(2) bortezomib. Bortezomib significantly enhances the sensitivity of patient myeloma to allogeneic and autologous NK cell-mediated lysis. Further, the level of decrease in class I expression correlates with increased susceptibility to lysis by NK cells. Clinically relevant bortezomib concentrations do not affect NK-cell function. Our findings have clear therapeutic implications for MM and other NK cell-sensitive malignancies in the context of both allogeneic and autologous adoptively transferred NK cells. 相似文献
107.
Arvind K Sharma Shadi M Hamwi Nidhi Garg Marco T Castagna William Suddath Samer Ellahham Joseph Lindsay 《Catheterization and cardiovascular interventions》2002,56(3):346-352
Cocaine-associated myocardial infarction (CAMI) is a well-reported entity. Most previous reports on CAMI have been limited to conservative care utilizing benzodiazepines, aspirin, nitroglycerin, calcium channel blockers, and thrombolytics. Current guidelines on CAMI advocate immediate use of angiography and angioplasty if available rather than routine administration of thrombolytics. However, based on literature search from 1966 to 2001 (using keywords "cocaine," "myocardial infarction," and "angioplasty"), there have been only two case reports of percutaneous coronary intervention (PCI) in patients with cocaine-associated myocardial infarction. Both were notable for complications either during or immediately after the procedure. We report a series of 10 patients with cocaine-associated myocardial infarction who were treated with percutaneous interventions, which included angioplasty, stenting, and AngioJet mechanical extraction of thrombus. Despite the different arteriopathic process involved, our findings suggest that PCI can be performed safely and with a high degree of procedural success in patients with CAMI. 相似文献
108.
109.
Congenital generalized lipodystrophy (CGL) is an autosomal recessive disorder characterized by extreme lack of body fat and severe insulin resistance since birth. Recently, mutations have been reported in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and Berardinelli-Seip congenital lipodystrophy 2 (BSCL2 or Seipin) genes in affected subjects from pedigrees linked to chromosomes 9q34 and 11q13, respectively. The AGPAT2 catalyses the acylation of the lysophosphatidic acid at the sn-2 position to form phosphatidic acid, a key intermediate in the biosynthesis of triacylglycerol and glycerophospholipids. High expression of AGPAT2 mRNA in adipose tissue compared to other isoforms suggests that the mutations might affect the adipose tissue the most. The function of BSCL2 remains unknown. Several CGL pedigrees reveal no mutation in either of the above genes and are not linked to these loci, suggesting additional genetic loci for CGL. Thus, several distinct mechanisms can lead to extreme lack of adipose tissue in humans and cause CGL. 相似文献