全文获取类型
收费全文 | 1755篇 |
免费 | 78篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 130篇 |
妇产科学 | 33篇 |
基础医学 | 294篇 |
口腔科学 | 27篇 |
临床医学 | 99篇 |
内科学 | 277篇 |
皮肤病学 | 69篇 |
神经病学 | 142篇 |
特种医学 | 65篇 |
外科学 | 203篇 |
综合类 | 27篇 |
预防医学 | 78篇 |
眼科学 | 149篇 |
药学 | 110篇 |
中国医学 | 6篇 |
肿瘤学 | 107篇 |
出版年
2023年 | 10篇 |
2022年 | 39篇 |
2021年 | 58篇 |
2020年 | 36篇 |
2019年 | 39篇 |
2018年 | 58篇 |
2017年 | 41篇 |
2016年 | 41篇 |
2015年 | 53篇 |
2014年 | 60篇 |
2013年 | 93篇 |
2012年 | 118篇 |
2011年 | 139篇 |
2010年 | 75篇 |
2009年 | 57篇 |
2008年 | 98篇 |
2007年 | 100篇 |
2006年 | 100篇 |
2005年 | 59篇 |
2004年 | 66篇 |
2003年 | 82篇 |
2002年 | 44篇 |
2001年 | 34篇 |
2000年 | 45篇 |
1999年 | 34篇 |
1998年 | 11篇 |
1997年 | 8篇 |
1996年 | 13篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 9篇 |
1992年 | 16篇 |
1991年 | 20篇 |
1990年 | 12篇 |
1989年 | 15篇 |
1988年 | 14篇 |
1987年 | 24篇 |
1986年 | 12篇 |
1985年 | 10篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1980年 | 3篇 |
1979年 | 8篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1973年 | 8篇 |
1972年 | 12篇 |
1971年 | 12篇 |
1970年 | 5篇 |
1969年 | 4篇 |
排序方式: 共有1834条查询结果,搜索用时 15 毫秒
61.
Paul M. Bunch Scott E. Sheehan George S. Dyer Aaron Sodickson Bharti Khurana 《Emergency radiology》2016,23(2):175-185
Distal radius fractures are the most common upper extremity fracture and account for approximately one sixth of all fractures treated in US emergency departments. These fractures are associated with significant morbidity and have a major economic impact. Radiographic evaluation of distal radius fractures is frequently performed in the emergency department setting, has a profound impact on initial management, and is essential to assessing the quality and relative success of the initial reduction. While the most appropriate definitive management of distal radius fractures remains controversial, overarching treatment principles reflect distal radius injury mechanisms and biomechanics. An intuitive understanding of the biomechanics of the distal radius and of common mechanisms of injury informs and improves the emergency radiologist’s ability to identify key imaging findings with important management implications and to communicate the critical information that emergency physicians and orthopedic surgeons need to best manage distal radius fractures. 相似文献
62.
A rare case of primary mucinous eccrine carcinoma of the lower eyelid in a 45 year old female is described. The lesion was diagnosed clinically as melanoma. We report this case because of unusual nature of this tumor and rare presentation in a female patient. 相似文献
63.
Tausif Alam Saba Khan Bharti Gaba Md. Faheem Haider Sanjula Baboota Javed Ali 《Journal of pharmaceutical sciences》2018,107(11):2914-2926
The present study demonstrated the systematic adaptation of quality by design-integrated approach for the development of novel nanostructured lipid carrier (NLC) of an anti-hypertensive drug isradipine (ISD) to address the inherent challenges such as low solubility and low oral bioavailability. Plackett-Burman design was used for preliminary screening of significant process and formulation variables (p <0.05), which were further processed using Box-Behnken design for the attainment of optimization goal that is, mean particle size (85.7 ± 7.3 nm), drug entrapment efficiency (87.4 ± 3.29%), and in vitro drug release characteristics (92.89 ± 5.47%). The optimized ISD-NLC formulation also demonstrated well-dispersed uniform-shaped particles (polydispersity index 0.207 ± 0.029), high gastrointestinal fluid stability (zeta potential ?10.17 ± 0.59 mV), and higher in vitro gut permeation (21.69 ± 2.38 μg/cm2 of ISD-NLC as compared to 11.23 ± 1.74 μg/cm2 in ISD suspension). Furthermore, lipolysis studies were performed for the purpose of in vivo fate, and significantly higher drug content of ISD from ISD-NLC in aqueous phase was found (72.34 ± 4.62%) as compared to drug suspension (3.01 ± 0.91%). Relative bioavailability of ISD-NLC and ISD suspension was increased by 4.2-fold and 1.78-fold in the absence and presence of cycloheximide which is a lymphatic uptake inhibitor revealing lymphatic uptake of ISD-NLC in bioavailability improvement. Hence, systematic adaptation of quality by design integrated approach improved gut permeation and potential solubilizaton fate (dynamic lipolysis) of ISD-NLC, which further improved the lymphatic uptake and biodistribution of drug thereby promisingits in vivo prospect and clinical efficacy. 相似文献
64.
Mahajan D Khurana N Setia N 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,103(3):e47-e50
Cysticercosis is a parasitic infestation caused by the pork tapeworm larval stage, Cysticercus cellulosae. The majority of the cases present in ocular, cerebral, and subcutaneous locations. We report the presence of cysticercosis inside the submandibular gland in association with squamous cell carcinoma of the inferior alveolar ramus of the mandible. To the best of our knowledge, this is the first case report documenting cysticercosis inside a salivary gland. A 65-year-old male presented with complaints of an ulcerative lesion on the inferior alveolar ramus present for 2 months. Histological examination revealed a keratinizing well-differentiated squamous cell carcinoma involving the alveolar margin and mandible. The histopathological examination of the submandibular gland revealed cysticercosis. This case emphasizes the importance of adequate sampling of all the tissues obtained for associated infectious disorders, more so in immunosuppressed patients, which will help the clinician to manage the case appropriately. 相似文献
65.
66.
Background Osteoarthritis at the thumb carpometacarpal joint can have a profound impact on quality of life. Here, we evaluate radiographic outcomes in patients who have had open complete trapeziectomy, ligament reconstruction with tendon interposition, and acellular dermal matrix (GraftJacket) interposition—Group A, and compare them with those without GraftJacket interposition—Group B. Materials and Methods Thirty patients who had undergone operative treatment for thumb basal joint arthritis by a single surgeon from 2009 to 2016 were identified, and charts were retrospectively reviewed for demographic data, surgical and radiographic outcomes, and complications. Results There was no significant difference in pre- and postoperative radial abduction or pre- and postoperative palmar abduction. The difference in intraoperative joint space was significant ( p = 0.006), but the difference in postoperative joint space was not ( p = 0.310). The average amount of metacarpal settling was 6.9 versus 3.7 mm ( p = 0.035) (Groups A and B, respectively). Three patients in Group A developed an inflammatory reaction to the GraftJacket, and one required reoperation for allograft removal. Conclusion This study suggests that thumb basal joint arthroplasty with GraftJacket interposition does not lead to more favorable radiographic outcomes at long-term follow-up. The increased costs associated with GraftJacket use may not be justified in light of these outcomes. 相似文献
67.
68.
Anu Gupta Vishal Jogi Manoj Kumar Goyal Manish Modi Dheeraj Khurana 《Annals of Indian Academy of Neurology》2014,17(4):426-428
Chronic aseptic meningitis is a rare manifestation of systemic lupus erythematosus (SLE). Apart from immunological causes and drugs, the aseptic meningitis group can include some unidentified viral infections that cannot be detected by routine microbiological testing. It is imperative to do complete cerebrospinal fluid (CSF) workup before implicating the symptoms to disease activity or drugs, as untreated infections cause significant mortality in SLE. We present a case of young female with SLE who presented with chronic meningitis of an uncommon etiology. 相似文献
69.
Restless leg syndrome (RLS) is a common disorder causing sleep impairment. Antipsychotics particularly belonging to the first generation are a common cause of RLS. Whereas, RLS induced by olanzapine is rare, there are only a few cases reported earlier. We report a 38-year-old lady suffering from persistent delusional disorder who was prescribed olanzapine. She developed RLS after initiation of olanzapine which improved when switched over to risperidone. This report will caution clinicians about this side effect of a very commonly prescribed antipsychotic drug.KEY WORDS: Olanzapine, restless legs syndrome 相似文献
70.
Goyal Abhishek Pakhare Abhijit Subhedar Rashmi Khurana Alkesh Chaudhary Poonam 《Sleep & breathing》2021,25(4):1867-1873
Sleep and Breathing - Positional therapy has been described as add-on therapy to a mandibular advancement device, but the efficacy of combination of positional therapy and positive airway pressure... 相似文献