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21.
Thymic cysts in mediastinal Hodgkin disease 总被引:3,自引:0,他引:3
Three cases of proved thymic cysts associated with mediastinal Hodgkin disease are presented. Two illustrate regression of lymphoma with chemotherapy but persistence of thymic cysts. The third case demonstrates a thymic cyst in untreated Hodgkin disease. These cases suggest that such cysts are probably neither coincidental with nor a consequence of therapy but are probably related to initial thymic involvement by Hodgkin disease. 相似文献
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Baslow MH Suckow RF Berg MJ Marks N Saito M Bhakoo KK 《Journal of molecular neuroscience : MN》2001,17(3):351-359
N-acetyl-L-histidine (NAH) and N-acetyl-L-aspartate (NAA) are representatives of two series of substances that are synthesized
by neurons and other cells in the vertebrate central nervous system (CNS). Histidine containing homologs of NAH are β-alanyl-L-histidine
or carnosine (Carn) and γ-aminobutyrl-L-histidine or homocarnosine (Hcarn). A homolog of NAA is N-acetylaspartylglutamate
(NAAG). These substances belong to a unique group of osmolytes in that they are synthesized in cells that may not to be able
to hydrolyze them, and are released in a regulated fashion to a second compartment where they can be rapidly hydrolyzed. In
this investigation, the catabolic activities for NAH, Carn, and Hcarn in cultured macroglial cells and neurons have been measured,
and the second compartment for NAH and Hcarn has been identified only with astrocytes. In addition, oligodendrocytes can only
hydrolyze Carn, although Carn can also be hydrolyzed by astrocytes. Thus, astrocytes express hydrolytic activity against all
three substrates, but oligodendrocytes can only act on Carn. The cellular separation of these hydrolytic enzyme activities,
and the possible nature of the enzymes involved are discussed. 相似文献
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KM RAI KJ PHILIPOSE VSM P TAKKAR RR BHONDE KK MAUDAR NK PANICKER 《Medical Journal Armed Forces India》1999,55(2):119-122
Current synthetic vascular prostheses do not acquire lining of vascular endothelium in humans or dogs. Endothelial seeding of vascular grafts has been proposed as a means of reducing the thrombogenicity of these grafts. We examined feasibility of cultivating endothelial cells (EC) by tissue culture technique and their subsequent seeding onto small diameter polytetra fluoroethylene (PTFE) grafts. Twenty adult dogs underwent common carotid artery interposition with 4 mm PTFE grafts. Ten dogs received seeded and the remaining ten received unseeded grafts. Grafts were removed at 4 and 12 weeks and their gross/morphological features compared. Cumulative patency rates for seeded grafts were 70% as compared to unseeded ones 30%. Seeded grafts were completely surfaced with a mono-layer of endothelium by 4 weeks. Small graft patency appears to be related to the establishment of an endothelial surface, the development of which is clearly facilitated by seeding with autogenous endothelium.KEY WORDS: Endothelial cell seeding, Vascular grafts 相似文献
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Geenes VL Lim YH Bowman N Tailor H Dixon PH Chambers J Brown L Wyatt-Ashmead J Bhakoo K Williamson C 《Placenta》2011,32(12):1026-1032
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disease associated with significant risk of fetal complications. It is hypothesised that the risk of adverse fetal outcomes relates to the toxic effects of bile acids, the levels of which are increased in both maternal and fetal serum. Human and rodent studies have shown that transplacental transfer of bile acids is impaired in ICP. Furthermore, the morphology of placentas from the rodent model of ICP is markedly abnormal, and is associated with increased expression of apoptotic markers and oxidative stress. Using placental tissue from ICP cases and normal pregnancies and cultured placental explant fragments we investigated the histological and molecular effects of cholestasis. We also examined the influence of ursodeoxycholic acid (UDCA) administration on these parameters. Here we report that ICP is associated with several morphological abnormalities of the placenta, including an increase in the number of syncytial knots, and that these can be reproduced in an in vitro (explant) model exposed to the bile acids taurocholic acid and taurochenodoexycholic acid. Furthermore, we demonstrate that ursodeoxycholic acid, a drug commonly used in the management of ICP, has a protective effect on placental tissue both in vivo and in vitro. 相似文献
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