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81.
Laurent De Landsheere Carine Munaut Betty Nusgens Catherine Maillard Chrystèle Rubod Michelle Nisolle Michel Cosson Jean-Michel Foidart 《International urogynecology journal》2013,24(12):2011-2020
Introduction and hypothesis
The pathophysiology of pelvic organ prolapse (POP) is incompletely understood. The purpose of this study is to describe the current knowledge about histology of the vaginal wall and its possible involvement in the pathogenesis of pelvic organ prolapse.Methods
Eligible studies were selected through a MEDLINE search covering January 1986 to December 2012. The research was limited to English-language publications.Results
Investigations of changes in the vaginal tissue that occur in women with genital prolapse are currently still limited and produced contrary results. The heterogeneity of the patients and the control groups in terms of age, parity and hormonal status, of the localization of biopsies and the histological methods as well as the lack of validation of the quantification procedures do not allow clear and definitive conclusions to be drawn.Conclusions
This review shows that current knowledge of the histological changes observed in women with POP are inconclusive and relatively limited. More studies are needed in this specific field to better understand the mechanisms that lead to POP. 相似文献82.
Tina D. Tailor Betty C. Tong Junheng Gao Kingshuk Roy Choudhury Geoffrey D. Rubin 《Journal of the American College of Radiology》2019,16(12):1663-1668
ObjectiveThe association between access to CT facilities for lung cancer screening and population characteristics is understudied. We aimed to determine the relationship between census tract–level socioeconomic characteristics (SEC) and driving distance to an ACR-accredited CT facility.MethodsCensus tract–level SEC were determined from the US Census Bureau. Distance to nearest ACR-accredited CT facility was derived at the census tract level. Census tract–level multivariable regression modeling was used to determine the relationship between driving distance to a CT facility and census tract SEC, including population density (a marker of rural versus urban), gender, race, insurance status or type, and education level.ResultsIn an adjusted multivariable model, census tract–level population density was the greatest relative determinant of distance to a CT facility. Namely, rural census tracts had relatively longer distances to CT facilities than urban census tracts (P < .001). Census tracts with higher uninsured, Medicaid, undereducated (less <high school degree) populations had relatively greater distances to CT facilities (p<0.001), whereas those with higher non-White, female, and Medicare populations had shorter distances (p<0.001).DiscussionRural populations have relatively less geographic access to CT facilities. Furthermore, other vulnerable populations, such as the uninsured, those on Medicaid, and the undereducated, may also have relatively less access to CT imaging facilities. These variations in access to CT may affect the uptake and utilization of lung cancer screening. 相似文献
83.
A resilience intervention involving mindfulness training for transplant patients and their caregivers 下载免费PDF全文
Cynthia M. Stonnington Betty Darby Angela Santucci Pamela Mulligan Patricia Pathuis Andrea Cuc Joseph G. Hentz Nan Zhang David Mulligan Amit Sood 《Clinical transplantation》2016,30(11):1466-1472
Solid organ and stem cell transplant patients and their caregivers report a substantial level of distress. Mindfulness‐based stress reduction has been shown to alleviate distress associated with transplant, but there is limited experience in this population with other mindfulness‐based interventions, or with combined transplant patient and caregiver interventions. We evaluated a novel, 6‐week mindfulness‐based resilience training (MBRT) class for transplant patients and their caregivers that incorporates mindfulness practice, yoga, and neuroscience of stress and resilience. Thirty‐one heart, liver, kidney/pancreas, and stem cell transplant patients and 18 caregivers at Mayo Clinic in Arizona participated. Measures of stress, resilience, depression, anxiety, health‐related quality of life, positive and negative affect, and sleep were completed at baseline, 6 weeks, and 3 months postintervention. At 6 weeks and 3 months, patients demonstrated significant (P<.005) improvements from baseline in measures of perceived stress, depression, anxiety, and negative affect. Quality‐of‐life mental component (P=.006) and positive affect (P=.02) also improved at follow‐up. Most participants adhered to the program, were satisfied with class length and frequency, and reported improved well‐being as a result of the class. MBRT holds promise as an intervention to enhance resilience and manage stress for transplant patients and their caregivers. 相似文献
84.
Laurent de Landsheere Mathias Brieu Silvia Blacher Carine Munaut Betty Nusgens Chrystèle Rubod Agnès Noel Jean-Michel Foidart Michelle Nisolle Michel Cosson 《International urogynecology journal》2016,27(4):629-635
Introduction and hypothesis
The aim of the study was to correlate histological and biomechanical characteristics of the vaginal wall in women with pelvic organ prolapse (POP).Methods
Tissue samples were collected from the anterior [point Ba; POP Questionnaire (POP-Q)] and/or posterior (point Bp; POP-Q) vaginal wall of 15 women who underwent vaginal surgery for POP. Both histological and biomechanical assessments were performed from the same tissue samples in 14 of 15 patients. For histological assessment, the density of collagen and elastin fibers was determined by combining high-resolution virtual imaging and computer-assisted digital image analysis. For biomechanical testing, uniaxial tension tests were performed to evaluate vaginal tissue stiffness at low (C0) and high (C1) deformation rates.Results
Biomechanical testing highlights the hyperelastic behavior of the vaginal wall. At low strains (C0), vaginal tissue appeared stiffer when elastin density was low. We found a statistically significant inverse relationship between C0 and the elastin/collagen ratio (p?=?0.048) in the lamina propria. However, at large strain levels (C1), no clear relationship was observed between elastin density or elastin/collagen ratio and stiffness, likely reflecting the large dispersion of the mechanical behavior of the tissue samples.Conclusion
Histological and biomechanical properties of the vaginal wall vary from patient to patient. This study suggests that elastin density deserves consideration as a relevant factor of vaginal stiffness in women with POP.85.
86.
Prognostic value of p16 expression in Epstein‐Barr virus–positive nasopharyngeal carcinomas 下载免费PDF全文
Wen Jiang MD PhD Paul D. Chamberlain BS Adam S. Garden MD Betty Y. S. Kim MD PhD Dominic Ma BS Emily J. Lo MD Diana Bell MD G. Brandon Gunn MD Clifton D. Fuller MD PhD David I. Rosenthal MD Beth M. Beadle MD PhD Steven J. Frank MD William H. Morrison MD Adel K. El‐Naggar MD Bonnie S. Glisson MD Erich M. Sturgis MD PhD Jack Phan MD PhD 《Head & neck》2016,38(Z1):E1459-E1466
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Report of the first example of pure anti-Lua associated with hemolytic disease of the newborn. Of special interest is the fact that this serum demonstrated a marked prozone reaction in saline, papain and indirect Coombs titrations, and is the first anti-Lua serum to react well by the indirect Coombs technic. 相似文献