全文获取类型
收费全文 | 4102篇 |
免费 | 211篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 89篇 |
妇产科学 | 50篇 |
基础医学 | 459篇 |
口腔科学 | 179篇 |
临床医学 | 294篇 |
内科学 | 1083篇 |
皮肤病学 | 41篇 |
神经病学 | 490篇 |
特种医学 | 98篇 |
外科学 | 657篇 |
综合类 | 31篇 |
一般理论 | 1篇 |
预防医学 | 285篇 |
眼科学 | 72篇 |
药学 | 216篇 |
中国医学 | 5篇 |
肿瘤学 | 222篇 |
出版年
2023年 | 29篇 |
2022年 | 53篇 |
2021年 | 135篇 |
2020年 | 76篇 |
2019年 | 113篇 |
2018年 | 117篇 |
2017年 | 72篇 |
2016年 | 117篇 |
2015年 | 91篇 |
2014年 | 171篇 |
2013年 | 181篇 |
2012年 | 314篇 |
2011年 | 324篇 |
2010年 | 165篇 |
2009年 | 163篇 |
2008年 | 239篇 |
2007年 | 258篇 |
2006年 | 244篇 |
2005年 | 260篇 |
2004年 | 195篇 |
2003年 | 171篇 |
2002年 | 164篇 |
2001年 | 105篇 |
2000年 | 72篇 |
1999年 | 58篇 |
1998年 | 29篇 |
1997年 | 39篇 |
1996年 | 25篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 28篇 |
1991年 | 21篇 |
1990年 | 20篇 |
1989年 | 13篇 |
1988年 | 13篇 |
1987年 | 13篇 |
1986年 | 18篇 |
1985年 | 7篇 |
1984年 | 14篇 |
1983年 | 16篇 |
1982年 | 13篇 |
1979年 | 9篇 |
1978年 | 18篇 |
1977年 | 9篇 |
1976年 | 11篇 |
1975年 | 10篇 |
1974年 | 7篇 |
1971年 | 9篇 |
1969年 | 8篇 |
排序方式: 共有4324条查询结果,搜索用时 15 毫秒
61.
62.
63.
64.
Debora M. Miranda Bernardo L. Wajchenberg† Maria R. Calsolari‡ Marcos J. Aguiar José M. C. L. Silva§ Marcia G. Ribeiro¶ Cristina Fonseca¶ Daniela Amaral¶ Wolfanga L. Boson Bruna A. Resende Luiz De Marco 《Clinical endocrinology》2009,71(4):512-517
Context Congenital generalized lipodystrophy, or Berardinelli–Seip syndrome, is a rare autosomal recessive disease caused by mutations in either the BSCL2 or AGPAT2 genes. This syndrome is characterized by an almost complete loss of adipose tissue usually diagnosed at birth or early infancy resulting in apparent muscle hypertrophy. Common clinical features are acanthosis nigricans, hepatomegaly with or without splenomegaly and high stature. Acromegaloid features, cardiomyopathy and mental retardation can also be present.
Design We investigated 11 kindreds from different geographical areas of Brazil (northeast and southeast). All coding regions as well as flanking intronic regions of both genes were examined. Polymerase chain reaction (PCR) amplifications were performed using primers described previously and PCR products were sequenced directly.
Results Four AGPAT2 and two BSCL2 families harboured the same set of mutations. BSCL2 gene mutations were found in the homozygous form in four kindreds (c.412C>T c.464T>C, c.518–519insA, IVS5-2A>G), and in two kindreds compound mutations were found (c.1363C>T, c.424A>G). In the other four families, one mutation of the AGPAT2 gene was found (IVS3-1G>C and c.299G>A).
Conclusions We have demonstrated four novel mutations of the BSCL2 and AGPAT2 genes responsible for Berardinelli–Seip syndrome and Brunzell syndrome (AGPAT2-related syndrome). 相似文献
Design We investigated 11 kindreds from different geographical areas of Brazil (northeast and southeast). All coding regions as well as flanking intronic regions of both genes were examined. Polymerase chain reaction (PCR) amplifications were performed using primers described previously and PCR products were sequenced directly.
Results Four AGPAT2 and two BSCL2 families harboured the same set of mutations. BSCL2 gene mutations were found in the homozygous form in four kindreds (c.412C>T c.464T>C, c.518–519insA, IVS5-2A>G), and in two kindreds compound mutations were found (c.1363C>T, c.424A>G). In the other four families, one mutation of the AGPAT2 gene was found (IVS3-1G>C and c.299G>A).
Conclusions We have demonstrated four novel mutations of the BSCL2 and AGPAT2 genes responsible for Berardinelli–Seip syndrome and Brunzell syndrome (AGPAT2-related syndrome). 相似文献
65.
66.
67.
Seabra Rato Maria Bernardo Alexandra Oliveira Pinheiro Filipe Guimarães da Fonseca Diogo Costa Lúcia 《Clinical rheumatology》2022,41(11):3583-3584
Clinical Rheumatology - 相似文献
68.
de Lima Silva Alvaro Henrique Bernardo Radulski Debora Rasec Pereira Gabriela Saidel Acco Alexandra Zanoveli Janaina Menezes 《Metabolic brain disease》2022,37(4):1095-1110
Metabolic Brain Disease - Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type-1 diabetes mellitus (T1DM) are increasingly common comorbidities and the treatment is... 相似文献
69.
Fred M. Hunter MD Pelayo Correa MD Elizabeth Fontham DrPH Bernardo Ruiz MD Mahboob Sobhan PhD I. Chiael Samploff MD 《Digestive diseases and sciences》1993,38(11):2081-2086
We have investigated the effect of therapy forHelicobacter pylori gastritis on serum concentrations of pepsinogen I and II in 43 patients. In the 22 patients in whom therapy resulted in dramatic decrease in gastritis scores and in clearance of the bacteria, there was a highly significant (P=0.0001) fall in mean serum pepsinogen II from 13.3±0.8 to 7.9±0.7 μg/liter, and a less pronounced fall in pepsinogen I from 89.0±5.9 to 78.5±0.4 μg/liter (P=0.01). These changes resulted in a significant (P=0.01) increase in the pepsinogen I/II ratio. In contrast, nonsignificant declines of 3.5% and 11.6% were observed in mean pepsinogen I and II levels in the 21 patients whose gastritis failed to resolve histologically and whose infection did not clear. These findings suggest that serum pepsinogen levels, especially pepsinogen II, are a new tool that may be found to be clinically useful in evaluation of treatment outcome in patients withH. pylori-associated gastritis. 相似文献
70.
Selim AJ Fincke G Berlowitz DR Miller DR Qian SX Lee A Cong Z Rogers W Selim BJ Ren XS Spiro A Kazis LE 《The journals of gerontology. Series A, Biological sciences and medical sciences》2005,60(4):515-519
BACKGROUND: Information on the health status of centenarians provides a means for understanding the health care needs of this growing population. Therefore, we examined the health status of a national cohort of centenarian veteran enrollees. METHODS: Ninety-three centenarian veteran enrollees returned a complete health history questionnaire, which included questions about sociodemographic information, age-associated conditions, health behaviors, health-related quality of life as measured by the Veterans SF-36, and change in health status. RESULTS: Centenarian veteran enrollees are a group with major impairment across multiple dimensions of health-related quality of life despite having a relatively low prevalence of diseases. They had considerable physical limitations as reflected by their physical health summary scores (26.2 +/- 8.3). However, their mental health was comparatively good (mental health summary score 44.1 +/- 12.5). Compared to younger elderly veterans (ages 85-99), centenarians had a lower prevalence of hypertension, angina or myocardial infarction, diabetes, and chronic low back pain (p <.05). Centenarians had significantly worse physical functioning, role physical, vitality, and social functioning scores than did younger elderly veterans. The two groups did not differ in their general health, bodily pain, role emotional, and mental health scores. Centenarians did not perceive much decline in their physical or mental health during the preceding year. CONCLUSIONS: Centenarian veteran enrollees are a group with a low number of age-associated diseases and good mental health despite substantial physical limitations. These results support future studies of services directed toward improvement of function as opposed to those focused solely on the treatment of diseases. 相似文献