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61.
Lai Q Molinaro A Spoletini G Mennini G Grieco M Merli M Corradini SG Berloco PB Rossi M 《Transplantation proceedings》2011,43(1):274-276
Introduction
The current shortage of organs for liver transplantation (OLT) requires expansion of the donor pools. A possible approach to this problem may be the use of donors positive for antibody against hepatitis B core antigen (anti-HBc). However, it is not clear whether recipients who receive anti-HBc-positive livers show worse survival. The aim of this study was to retrospectively analyze the patient and graft survivals of two groups of OLT recipients according to the anti-HBc status of their respective donors.Methods
We stratified 133 patients into group 1 (n = 120; anti-core-negative donors) versus group 2 (n = 13; anti-core-positive donors).Results
Comparing the two groups by univariate analysis, there was no significant differences with regard to recipient, donor, or transplant characteristics. Group 2 showed worse 5-year patient (46.2% vs 72.0%; P = .006) and graft survivals (38.5% vs 68.4%; P = .003). After adjustment for several risk factors for post-OLT death and graft failure, there was no significant difference between patients who received anti-core-positive versus anti-core-negative donors, in terms of patient and graft survivals, particularly only after adjustment for Model for End-stage Liver Disease (MELD) degree of severity.Conclusion
The use of anti-HBc-positive donors resulted in worse post-OLT patient and graft survival rates. Unlike the results obtained in the United States, we did not find possible confounders in our results, excluding MELD ≥ 20. However, due to the small size of our cohort, future prospective multicenter studies are required to clarify the safety of anti-core-positive grafts. 相似文献62.
This article reports the first case of immune hemolytic anemia possibly associated with the ingestion of suprofen. The patient suffered from massive hemoglobinuria and acute renal failure. Serologic studies of the patient's serum revealed suprofen-dependent red cell antibodies. However, tolmetin-dependent antibodies were also found in the serum, showing the same properties as the suprofen antibodies and an even higher titer. The patient not only had drug-dependent antibodies in the serum, but also had developed autoantibodies, a phenomenon that has been described for several other drugs. The working mechanism by which suprofen and tolmetin caused immune hemolysis had properties of both the immune complex model and the induction of autoimmunity. Although it was unclear whether the immune hemolytic anemia was the result of suprofen, tolmetin, or cross-reacting antibodies, we feel that suprofen should be added to the list of nonsteroidal anti-inflammatory drugs associated with a positive direct antiglobulin test. 相似文献
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66.
G Cucchiara A Famulari D Alfani P Berloco M Pelle Ceravolo F Rizzo 《Minerva chirurgica》1979,34(4):287-298
Five cases of kidney grafts followed by rupture are described. The explanation of the syndrome accompanying such an occurrence is deduced from personal observations as well as from literature data. As a matter of fact, the aetiopathology of this syndrome cannot be with an isolated cause, for several multifactorial immunological and non-immunological components may be involved. 相似文献
67.
Linsalata M Russo F Berloco P Valentini AM Caruso ML De Simone C Barone M Polimeno L Di Leo A 《In vivo (Athens, Greece)》2005,19(6):989-995
BACKGROUND: Probiotics seem to possess tumour inhibitory properties, but few studies have investigated their actions on the cell proliferation of normal colonic mucosa. The effects of a probiotic mixture (VSL#3) on polyamine biosynthesis, Ki-67 levels and apoptosis in the normal colon of rats were studied. MATERIALS AND METHODS: For a 4-week period, 20 rats were fed a VSL#3 solution and 20 rats a saline solution. Samples from the colonic mucosa were collected at the end of treatment. Polyamines were detected by HPLC, ornithine decarboxylase activity by a radiometric technique, and apoptosis and Ki-67 by histochemical and immunohistochemical methods. RESULTS: VSL#3 caused a significant decrease in colonic polyamine levels, ornithine decarboxylase activity and Ki-67 compared to controls. A significant increase in the apoptotic index was also observed. CONCLUSION: Probiotics could also reduce proliferation rates in a condition not affected by hyperproliferative or neoplastic growth, when the normal control mechanisms are still completely effective. 相似文献
68.
Novelli G Morabito V Pugliese F Ferretti G Novelli S Ianni S Lai Q Rossi M Berloco PB 《Transplantation proceedings》2011,43(4):1085-1090
Introduction
The aim of our study was a 30-day follow-up of the use of early detection of endotoxin by the endotoxin activity assay (EAA) for patients with acute liver failure superimposed on chronic liver disease (AoCLF) and treated with polymyxin-B hemoperfusion-based (PMX-DHP) treatment and albumin dialysis in the molecular adsorbent recirculating system (MARS).Materials and Methods
From February 2008 to July 2010, we evaluated 10 AoCLF patients experiencing systemic inflammatory response syndrome (SIRS) in association with suspected infection and an EAA-positive test (>0.60). These patients awaiting liver transplantation (OLT) showed similar Model End-Stage Liver Disease (MELD) scores (range, 19-25) and encephalopathy grade ≤ 2. Five patients received therapy to remove endotoxins with PMX-DHP with MARS treatment for liver failure (group A); the other 5 patients received MARS treatment only (group B).Results
Two PMX-DHP treatments were performed in 4 group A patients (average EA = 0.66 [range, 0.61-0.70]) and 3 treatments for 1 patient (EA = 0.92). All 5 subjects underwent an average of 4 MARS treatments (range, 3-5). At the end of therapy, the median EA level was 0.42 (range, 0.37-0.48). As reported in the literature, we achieved a significant improvement in liver and kidney functions using MARS. Measurements of lactate, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were significantly improved among patients treated with the extracorporeal therapies. At 30 days of observation, all 5 patients treated with MARS plus PMX-DHP are alive. In group B, a mean of 7.5 MRAS treatments were performed. We observed an improvement in hemodynamic and liver functions with reduced levels of proinflammatory cytokines and lactates in 4 patients. One patient showed no improvement in clinical status with the development of sepsis and subsequent multiorgan failure after 24 days.Conclusion
The possibility of an early diagnosis using the EAA in AoCLF patients could prevent the progression of the sepsis cascade. The use of PMX-DHP and MARS in these patients, could lead to resolution of clinical status in a short time. 相似文献69.
Lubrano R Elli M Rossi M Travasso E Raggi C Barsotti P Carducci C Berloco P 《Pediatric nephrology (Berlin, Germany)》2007,22(8):1209-1214
Methylmalonic acidemia (MMA) is an inborn error of organic acid metabolism. Patients with severe disease develop many complications
despite treatment; often, the disease progresses to severe damage of the central nervous system or to end-stage renal disease
(ESRD). When medical treatment is ineffective, liver, kidney, or combined liver and kidney transplantation is advocated. At
present, there are no definite guidelines as for the organ to be transplanted, and results are inconsistent. We report on
a 27-year-old woman with MMA MUT0. The clinical symptoms developed at age 4 months. She progressed to ESRD and received a kidney transplant in November 1996
at age 17 years. One hundred and twenty months after transplant, renal function is normal; although urinary levels of methylmalonic
acid are above normal limits, no episodes of metabolic decompensation have been observed after transplantation. Although liver
is the major site of methylmalonyl-CoA mutase activity, this case and similar ones in the literature suggest that the smaller
mutase activity present in the transplanted kidney may be sufficient to ensure partial correction of the metabolism of organic
acids sufficient to prevent the onset of episodes of metabolic decompensation. It is worth investigating whether kidney transplant
can be a safer and more satisfactory alternative to liver transplantation in cases of MMA unresponsive to medical treatment
although urine MMA excretion remains significantly elevated.
Source of financial support The study was made possible by an unrestricted grant from nuovArmonia nonprofit organization. 相似文献
70.
M. DAlessandro L. Poli Q. Lai A. Gaeta C. Nazzari M. Garofalo F. Nudo F. Della Pietra A. Bachetoni V. Sargentini A. Angeloni P.B. Berloco R. Pretagostini 《Transplantation proceedings》2019,51(1):157-159