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111.
Dewey Marc; Taubert Teodora; Hammerschmidt Robert; Dubel Hans-Peter 《European heart journal》2007,28(5):552
A 62-year-old man with typical angina pectoris was referredfor imaging of the coronary arteries to detect stenoses. Multislicecomputed tomography (CT) demonstrated significant 相似文献
112.
A 72-year-old man with increasing shortness of breath and atypicalangina pectoris received a chest radiograph 相似文献
113.
Estie Kruger Marc Tennant Kirrilee Smith Jacinta Peachey 《Australasian journal on ageing》2007,26(1):15-20
Objectives: The aim of this study was to assess, in a sample of older rural community‐dwelling Australians, their: oral health status, dental treatment needs, perceived barriers to access dental services and the prevalence and severity of dental anxiety. Methods: A cross‐sectional study of elderly rural Australians. Results: Eighty participants (mean age of 71.7 years) had a mean number of 0.69 (SD 1.6) decayed teeth, 15.72 (SD 13.3) missing teeth and 3.9 (SD 5.4) filled teeth. Forty‐one per cent were edentulous. Xerostomia was reported by 53% of the edentulous and 43% of the dentate. The average Corah Dental Anxiety Scale score was 8.72 (SD 3.8). Prevalence of dental anxiety was 15.6%. Two‐thirds needed dental treatment. Conclusions: Caries experience was lower than that reported in other studies. Reported barriers to use of dental services were long waiting times, lack of perceived dental need and costs. 相似文献
114.
Salom El Hage Michle Ane Jean-Luc Stigliani Maynadier Marjorie Henri Vial Genevive Baziard-Mouysset Marc Payard 《European journal of medicinal chemistry》2009,44(11):4778-4782
In this paper we describe the design and synthesis of 18 derivatives of the antimicrobial atovaquone which were substituted at the 3-hydroxy group by ester and ether functions. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. All the compounds showed potent activity, with IC50 values in the range of 1.25–50 nM, comparable to those of atovaquone and much higher than chloroquine or quinine. 相似文献
115.
116.
Analysis of count data from clinical trials using mixed effect analysis has recently become widely used. However, algorithms
available for the parameter estimation, including LAPLACE and Gaussian quadrature (GQ), are associated with certain limitations,
including bias in parameter estimates and the long analysis runtime. The stochastic approximation expectation maximization
(SAEM) algorithm has proven to be a very efficient and powerful tool in the analysis of continuous data. The aim of this study
was to implement and investigate the performance of a new SAEM algorithm for application to count data. A new SAEM algorithm
was implemented in MATLAB for estimation of both, parameters and the Fisher information matrix. Stochastic Monte Carlo simulations
followed by re-estimation were performed according to scenarios used in previous studies (part I) to investigate properties
of alternative algorithms (Plan et al., 2008, Abstr 1372 []). A single scenario was used to explore six probability distribution models. For parameter estimation, the relative bias
was less than 0.92% and 4.13% for fixed and random effects, for all models studied including ones accounting for over- or
under-dispersion. Empirical and estimated relative standard errors were similar, with distance between them being <1.7% for
all explored scenarios. The longest CPU time was 95 s for parameter estimation and 56 s for SE estimation. The SAEM algorithm
was extended for analysis of count data. It provides accurate estimates of both, parameters and standard errors. The estimation
is significantly faster compared to LAPLACE and GQ. The algorithm is implemented in Monolix 3.1, (beta-version available in
July 2009). 相似文献
117.
Marc Tey Joan C. Monllau Josep M. Centenera Xavier Pelfort 《Knee surgery, sports traumatology, arthroscopy》2007,15(10):1235-1239
The purpose of this work was to describe the posterior ankle impingement syndrome related to the posterolateral tubercle of
the talus bone and to present a retrospective analysis of our results after arthroscopic plasty of the tubercle in 15 ankles
with a mean 3-year follow-up. Fifteen cases of posterior ankle impingement (PAI) underwent arthroscopic excision of an impinging
bone spur. All the patients (13) were retrospectively evaluated at an average of 36 months after index surgery. There were
seven women (bilateral in two of them) and six men. Ten were involved in different kinds of sport and three were professional
ballet dancers. Preoperative symptoms included pain localized in the posterior ankle, limitation of motion, weakness and swelling.
All patients had failed a course of conservative therapies. Surgery was performed through posterolateral and posteromedial
portals as described by van Dijk. After soft tissue debridement, partial resection of the posterolateral process was performed
until there was complete plantar flexion without bone impingement. Postoperatively, all patients followed the same rehabilitation
protocol. Improvement in their impingement symptoms was recorded in all of them according to AOFAS score. One of them (7%)
still had occasional discomfort. The results suggest that arthroscopic bone decompression of the posterolateral tubercle in
cases of PAI resistant to non-surgical therapies is an effective treatment. 相似文献
118.
Stewart A. Daniels Kevin G. Coonley Marc O. Yoshizumi 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1990,228(6):513-516
Taxol is a potent stabilizer of microtubules, and inhibitor of in vitro replication, migration, and contraction of fibroblasts. It has been found to limit the development of experimental tractional retinal detachments in nonvitrectomized rabbit eyes. We used taxol in vitrectomized, phakic rabbit eyes with experimentally induced proliferative vitreoretinopathy and tractional retinal detachments. Taxol was dissolved in 30% DMSO because of poor aqueous solubility. A single 0.1 ml intravitreal dose of 2 × 10–4
M taxol in 30% DMSO was injected immediately after 250000 heterologous corneal fibroblasts had been injected; 0.1 ml of 30% DMSO was injected into control eyes. Taxol reduced the incidence of tractional retinal detachments seen 3–4 weeks later. When taxol injection was delayed for 3 days after the initial intravitreal injection of fibroblasts into nonvitrectomized eyes, the extent of retinal detachments was reduced, but the incidence of retinal detachment was unchanged from the untreated eyes at the end of 4 weeks. These data indicate that taxol may be most useful when given early in the course of proliferative vitreoretinopathy.Dr. Stewart Daniels was an Abe Meyer Fellow 相似文献
119.
Farida Daïkha-Dahmane Françoise Narcy Marc Dommergues Mireille Lacoste Agnes Beziau Marie-Claire Gubler 《Pediatric nephrology (Berlin, Germany)》1997,11(3):267-273
An alteration in cell/matrix interactions is one of the suggested mechanisms leading to cyst formation in polycystic kidney
diseases. Most of these interactions are mediated by β1-integrins, a subfamily of integrin receptors, formed by the association
of the β1-chain with different α-subunits. To date, no study on α-integrin subunit distribution during the early stages of
cyst development has been reported. Using immunofluorescence, we analyzed the distribution of α-integrin subunits (α1, α2,
α3, α5, and α6) and basement membrane proteins in kidneys of fetuses with autosomal dominant (ADPKD) or autosomal recessive
polycystic kidney disease (ARPKD). The distribution was compared with that observed in normal fetal and post-natal kidneys,
and in fetal cystic dysplasia and Meckel syndrome. Marked increase in α1-integrin staining was observed in normal and cystic
collecting duct cells of both polycystic diseases (PKD), compared with normal and cystic controls. The distribution of integrin
subunits α2, α3, and α6 was irregular in cyst epithelial cells of PKD and cystic controls. The increased expression of the
α1-subunit specifically observed in PKD collecting duct cells may be an early consequence of the genetic defect in ARPKD.
In ADPKD it parallels the reported expression of polycystin, the protein product of PKD1. The irregular expression of α2,
α3, and α6 integrin subunits observed in all types of cysts suggests that cell/matrix interactions are altered early and may
participate in the development of cysts, perhaps by contributing to the deregulation of cell survival in cystic diseases.
Received May 28, 1996; received in revised form October 2, 1996; accepted October 25, 1996 相似文献
120.
Respiratory failure with diffuse patchy lung infiltrates: an unusual presentation of squamous cell carcinoma 下载免费PDF全文
Marc Meysman Danny F Schoors Hendrik Reynaert Marc Noppen Erwin Pierre Walter Vincken 《Thorax》1994,49(12):1271-1272
The case history is presented of a patient with squamous cell carcinoma of the lung with diffuse bilateral pulmonary shadowing mimicking bronchioloalveolar cell carcinoma which led to type I respiratory failure. 相似文献