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排序方式: 共有2495条查询结果,搜索用时 15 毫秒
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Fara BrasMaristany Laia Par Nuria Chic Olga MartínezSez Toms Pascual Meritxell MallafrLarrosa Francesco Schettini Blanca GonzlezFarr Esther Sanfeliu Dbora Martínez Patricia Galvn Esther Barnadas Belinda Salinas Pablo Tolosa Eva Ciruelos Esther Carcelero Cecilia Guilln Barbara Adamo Reinaldo Moreno Maria Vidal Montserrat Muoz Aleix Prat 《Molecular oncology》2022,16(1):69
In advanced breast cancer, biomarker identification and patient selection using a metastatic tumor biopsy is becoming more necessary. However, the biology of metastasis according to the organ site is largely unknown. Here, we evaluated the expression of 771 genes in 184 metastatic samples across 11 organs, including liver, lung, brain, and bone, and made the following observations. First, all PAM50 molecular intrinsic subtypes were represented across organs and within immunohistochemistry‐based groups. Second, HER2‐low disease was identified across all organ sites, including bone, and HER2 expression significantly correlated with ERBB2 expression. Third, the majority of expression variation was explained by intrinsic subtype and not organ of metastasis. Fourth, subtypes and individual subtype‐related genes/signatures were significantly associated with overall survival. Fifth, we identified 74 genes whose expression was organ‐specific and subtype‐independent. Finally, immune profiles were found more expressed in lung compared to brain or liver metastasis. Our results suggest that relevant tumor biology can be captured in metastatic tissues across a variety of organ sites; however, unique biological features according to organ site were also identified and future studies should explore their implications in diagnostic and therapeutic interventions. 相似文献
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Advantages of Anti-Inflammatory Acupuncture in Treating Sepsis of Coronavirus Disease 2019 下载免费PDF全文
Guan-Yuan Jin Louis Lei Jin Jin Zheng Belinda Jie He 《World Journal of Traditional Chinese Medicine》2020,(2)
Background: Sepsisis one of the mostserious complications and a leading cause of death in patients with coronavirus disease 2019 (COVID-19).
In general, it isthe result of an unregulated inflammatory cascade such as a postinfection “cytokine storm.” The conventional treatment mainly
relies on glucocorticoids, of which curative effects are not ideal, as they come with significant side effects. It is critical to seek or develop other
effective therapeutics in dealing cytokine storm to fight COVID-19 with sepsis. Aims and Objectives: Raise awareness of the significance
applying anti-inflammatory acupuncture in dealing COVID-19 patients with sepsis and provide an appropriate acupuncture protocol that can be
easily integrated into existing medical guideline. Materials and Methods: Current evidences from animal experiments and clinical trials about
acupuncture in treating infectious sepsis are reviewed, and a detailed discussion on advantages of anti?inflammatory acupuncture is followed,
then the rationality on the point selection and stimulation parameters of acupuncture is analyzed to propose an appropriate acupuncture protocol.
Results: Current experiments have shown that acupuncture can play a significant role to improve inflammation reaction and reduce mortality
in infectious animal and patients with sepsis and its mechanisms are mainly achieved by stimulating the vagus?cholinergic anti?inflammatory
pathways.Applying acupuncture in treating COVID-19 patients with sepsis hasfour aspects of advantages. Moreover, a simple and convenient
clinical acupuncture protocol including point selection and appropriate stimulation parameters is proposed. Conclusion: Acupuncture,
especially electroacupuncture, has shown potentials in effectively treating infectious sepsis of animal models and critically ill patients in small
sample studies by stimulating the nervous system, but has been largely overlooked in the clinic so far. It is advised that acupuncture should
be integrated into the existing medical guidelines in dealing with COVID-19 complicated with sepsis. 相似文献
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Mathuri Sivakumar Akash Gandhi Eathar Shakweh Yu Meng Li Niloufar Safinia Belinda Claire Smith Aileen Marshall Lucy Turner Ashis Mukhopadhya Hasan Nadim Haboubi Rebecca Vincent Huey Kuan Tan Laith Alrubaiy David E J Jones 《Frontline Gastroenterology》2022,13(1):32
ObjectivePrimary biliary cholangitis (PBC) is a progressive, autoimmune, cholestatic liver disease affecting approximately 15 000 individuals in the UK. Updated guidelines for the management of PBC were published by The European Association for the Study of the Liver (EASL) in 2017. We report on the first national, pilot audit that assesses the quality of care and adherence to guidelines.DesignData were collected from 11 National Health Service hospitals in England, Wales and Scotland between 2017 and 2020. Data on patient demographics, ursodeoxycholic acid (UDCA) dosing and key guideline recommendations were captured from medical records. Results from each hospital were evaluated for target achievement and underwent χ2 analysis for variation in performance between trusts.Results790 patients’ medical records were reviewed. The data demonstrated that the majority of hospitals did not meet all of the recommended EASL standards. Standards with the lowest likelihood of being met were identified as optimal UDCA dosing, assessment of bone density and assessment of clinical symptoms (pruritus and fatigue). Significant variations in meeting these three standards were observed across UK, in addition to assessment of biochemical response to UDCA (all p<0.0001) and assessment of transplant eligibility in high-risk patients (p=0.0297).ConclusionOur findings identify a broad-based deficiency in ‘real-world’ PBC care, suggesting the need for an intervention to improve guideline adherence, ultimately improving patient outcomes. We developed the PBC Review tool and recommend its incorporation into clinical practice. As the first audit of its kind, it will be used to inform a future wide-scale reaudit. 相似文献
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Belinda S. Cowling Thierry Chevremont Ivana Prokic Christine Kretz Arnaud Ferry Catherine Coirault Olga Koutsopoulos Vincent Laugel Norma B. Romero Jocelyn Laporte 《The Journal of clinical investigation》2014,124(3):1350-1363
Centronuclear myopathies (CNM) are congenital disorders associated with muscle weakness and abnormally located nuclei in skeletal muscle. An autosomal dominant form of CNM results from mutations in the gene encoding dynamin 2 (DNM2), and loss-of-function mutations in the gene encoding myotubularin (MTM1) result in X-linked CNM (XLCNM, also called myotubular myopathy), which promotes severe neonatal hypotonia and early death. Currently, no effective treatments exist for XLCNM. Here, we found increased DNM2 levels in XLCNM patients and a mouse model of XLCNM (Mtm1–/y). Generation of Mtm1–/y mice that were heterozygous for Dnm2 revealed that reduction of DNM2 in XLCNM mice restored life span, whole-body strength, and diaphragm function and increased muscle strength. Additionally, classic CNM-associated histological features, including fiber atrophy and nuclei mispositioning, were absent or reduced. Ultrastructural analysis revealed improvement of sarcomere organization and triad structures. Skeletal muscle–specific decrease of Dnm2 during embryogenesis or in young mice after disease onset revealed that the rescue associated with downregulation of Dnm2 is cell autonomous and is able to stop and potentially revert XLCNM progression. These data indicate that MTM1 and DNM2 regulate muscle organization and force through a common pathway. Furthermore, despite DNM2 being a key mechanoenzyme, its reduction is beneficial for XLCNM and represents a potential therapeutic approach for patients. 相似文献
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Jeanne S. Chow Harriet J. Paltiel Horacio M. Padua Erin McNamara Belinda H. Dickie 《Journal of ultrasound in medicine》2019,38(10):2777-2783
This case series describes a novel method for showing the preoperative anatomy of children with anorectal malformations using ultrasound contrast, which we have termed “contrast‐enhanced colosonography (ceCS).” Six patients with anorectal malformations without a perineal fistula were studied both by fluoroscopic distal colostography and ceCS, and their results were confirmed surgically. Contrast‐enhanced CS precisely showed the complex anatomic relationships in all cases. Compared to traditional fluoroscopic studies, ceCS has the benefit of no associated ionizing radiation and thus is safer for children. 相似文献
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